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The molecular epidemiology of HIV-1 in Iceland has not been described so far. Detailed analyses of the dynamics of HIV-1 can give insights for prevention of virus spread. The objective of the current study was to characterize the genetic diversity and transmission dynamics of HIV-1 in Iceland. Partial HIV-1 pol (1020bp) sequences were generated from 230 Icelandic samples, representing 77% of all H

How should the development of creativity be approached? Many accounts of children’s creativity focus on the relation between creativity and pretend play, placing make-believe and the mental exploration of possible scenarios about the world at the fore. Often divergent thinking and story-telling are used to measure creativity with fluency, originality, and flexibility as indicators. I will argue th

Researchers often aim to make correct inferences both about that which is actually studied (internal validity) and about what the results generalize to (external validity). The language of internal and external validity is not used by everyone, but many of us would agree that intuitively the distinction makes a lot of sense. Two claims are commonly made with respect to internal and external validi

This paper explores the concept of organizations as complex human activity systems, through the perspectives of alternative systemic models. The impact of alternative models on perception of individual and organizational emergence is highlighted. Using information systems development as an example of management activity, individual and collective sense-making and learning processes are discussed.

Popular Abstract in Swedish Den moderna epokens början återfinns i det sena sjuttonhundratalet och i Europa. Det är en epok, en kultur som förstår sig som både ny och som annorlunda i förhållande till tidigare epoker och kulturer, sådana som vilat på myter, religion och tradition. Den nya kulturens fundamentala insikt bestod i att ingenting måste vara så som det är, utan allt vore möjligt också påThe problem which the present study discusses is modernity. The study interprets modernity’s cultural and anthropological dispositions as historical appearances. Consequently, it is situated at the intersection of cultural sociology and historical anthropology. The aim is to generate insight and understanding rather than a coherent theory. The key element consists of combination and variation of c

Värdepappershandel tillsammans med annan finansiell verksamhet har undantagits från mervärdesskatteplikt inom EU sedan 1977, när Direktivet 77/388/EEC lagstiftades. Ursprungligen stadgades undantaget för dessa finansiella tjänster på grund av skattetekniska problem som uppkommer vid framställande av det beskattningsbara underlaget. Direktivet, som sedermera har ersatts av Direktivet 2006/112/EC (tTrade in securities along with other financial activities has been enjoying the VAT exempt status within the EU since 1977, when Directive 77/388/EEC was passed. The VAT exemption for the financial services was originally enacted due to the difficulties relating to defining the taxable amount for the VAT purposes. The mentioned Directive, which has consequently been replaced by Directive 2006/112/

BACKGROUND: The role of ribonucleases in tuberculosis among people with human immunodeficiency virus (HIV; PWH) is unknown. We explored ribonuclease activity in plasma from PWH with and without tuberculosis.METHODS: Participants were identified from a cohort of treatment-naive PWH in Ethiopia who had been classified for tuberculosis disease (HIV positive [HIV+]/tuberculosis positive [tuberculosis+

Collagen-induced arthritis (CIA) is a T cell-dependent autoimmune disease that serves as an animal model for human rheumatoid arthritis. CIA can be induced in H-2q mice by a single immunization with the cartilage-specific protein type II collagen (CII). This study has focused on CII immunity and tolerance with respect to the interactions between antigen, antigen-presenting cells and T cells. CIA-r

In agriculture, as in industry, have many physically demanding jobs disappeared and the physical stress factors have changed. However, the working days in farms are often long, and it is difficult to hire workers for help as the work conditions are considered to be harsh. The thermal work environment in farms is one of the factors influencing the work conditions. This study aimed to find out the p

We present a study of a novel variant of the Self-Organizing Map (SOM) called the Associative Self-Organizing Map (A-SOM). The A-SOM is similar to the SOM and thus develops a representation of its input space, but in addition it also learns to associate its activity with the activity of one or several external SOMs. The A-SOM has relevance in e.g. the modelling of expectations in one modality due

Many patients with asthma or chronic obstructive pulmonary disease (COPD) routinely receive a combination of an inhaled bronchodilator and anti-inflammatory glucocorticosteroid, but those with severe disease often respond poorly to these classes of drug. We assessed the efficacy and safety of a novel inhaled dual phosphodiesterase 3 (PDE3) and PDE4 inhibitor, RPL554 for its ability to act as a bro

A major barrier for cancer immunotherapy is the presence of suppressive cell populations in patients with cancer, such as myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM), which contribute to the immunosuppressive microenvironment that promotes tumor growth and metastasis. Tasquinimod is a novel antitumor agent that is currently at an advanced stage of clinical develo

Abstract in UndeterminedThis article points to four worrisome aspects of the Court’s reasoning in Rantsev v. Cyprus and Russia. First, the Court takes on board the concept of ‘human trafficking’ without offering any meaningful legal analysis as to the elements of the human trafficking definition. Second, the adoption of the human trafficking framework implicates the ECtHR in anti-immigration and a

Popular Abstract in Swedish En annan modernism? Form, innehåll och betydelse av ny bostadsarkitektur i Hanoi.The study deals with the issue of how to understand and assess modern architecture in a non-Western context. Is there a non-Western modern architecture in its own right and with meanings connected to the local context or is it mere copy of Western modern architecture? At the primary level the study discusses the meanings and directions of contemporary architecture in a modernising society such as