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Circulating inflammatory markers are essential to human health and disease, and they are often dysregulated or malfunctioning in cancers as well as in cardiovascular, metabolic, immunologic and neuropsychiatric disorders. However, the genetic contribution to the physiological variation of levels of circulating inflammatory markers is largely unknown. Here we report the results of a genome-wide gen

The luminosity monitor LUCID (LUminosity Cherenkov Integrating Detector) employed in the ATLAS experiment at the LHC had to be upgraded for the second run of LHC (Run 2) that started in spring 2015. The increased energy of the proton beams and the higher luminosity implied that the Photomultipliers of the original LUCID detector had to be replaced for Run 2 to cope with the more demanding conditio

CD59 is a cell-surface inhibitor of the terminal step in the complement cascade. However, in addition to its complement inhibitory function, a non-canonical role of CD59 in pancreatic beta cells has been identified. Two recently discovered intracellular alternative splice forms of CD59, IRIS-1 and IRIS-2, are involved in insulin exocytosis through interactions with SNARE-complex components. In mic

Healthcare policy making is complex, requiring both human expertise and data-driven support. Agent-based Social Simulations (ABSS) provide a powerful tool for testing the potential consequences of healthcare policy interventions in a controlled environment. By integrating computational modeling with expert knowledge, ABSS enable hybrid-human policy collaborations, where simulation results support

In this preliminary study, the influence of a subsequent heat treatment after extrusionExtrusion and swagingSwaging on the microstructureMicrostructure, hardness, and corrosionCorrosion behavior of Mg0.15Ca was investigated. Heat treatment was carried out at 300, 400 and 500 °C for 1 h, and 16 h at 500 °C. Immersion in HBSS and Ringer's solution was done for up to 7 days. With increasing heat trea

Purpose: To compare the performance of targeted temperature management (TTM) at 33 °C using intravascular (IC) vs. surface-cooling (SFC) devices after out-of-hospital cardiac arrest (OHCA). Methods: A post hoc analysis including OHCA patients randomized to hypothermia in the TTM2-trial (NCT02908308) comparing hypothermia with normothermia. The main outcome was cooling performance, defined as the p

Background: Few previous studies have examined the prevalence of giant cell arteritis (GCA). The main objective of this study is to investigate the prevalence of temporal artery positive GCA (TAB+GCA) in southern Sweden.Methods: The study area is the region of Skåne in southern Sweden with a population of 1,3 million inhabitants (36% aged ⩾50 years). To be included in the study, patient should ful

Introduction: Preeclampsia (PE) is a human specific pregnancy-related syndrome of unknown etiology that affects 2–8 % of pregnancies. Polymorphism in maternal Killer Cell Immunoglobulin-like Receptors (KIRs) and the ligand fetal Human Leukocyte Antigen-C (HLA-C) may predispose pregnant mothers for PE due to defective trophoblast invasion into the maternal decidua. Our study aimed to investigate th

Historiskt sett har människor gjort invändningar grundade på tankefrihet, samvetsfrihet och religionsfrihet i förhållande till obligatorisk värnpliktstjänstgöring. Denna samvetsvägran inom militären är en erkänd rätt i nationella, regionala och internationella människorättsinstrument. I den Europeiska konventionen om skydd för de mänskliga rättigheterna och de grundläggande friheterna är denna rätHistorically, objections based on the freedom of thought, conscience and religion have been invoked in relation to compulsory military service. These conscientious objections are protected by national, regional and international human rights instruments. In the European Convention on Human Rights this right is grounded in Article 9 on the freedom of thought, conscience and religion. In Europe, the

The first aim of this study is to investigate what it takes for a nonprofit association (NPA) to become a legal entity, specifically regarding requirements addressing decision-making organs within the NPA’s organization. Secondly, since within the legal framework of associations there exist general principles of law, this study also explores which general principles of law are applicable to a gene

This thesis investigates the financial viability of green hydrogen production for mobility applications across four European countries: Germany, Norway, Denmark and Spain. Given the rising importance of hydrogen in hard-to-electrify sectors such as (heavy-duty) transport, the study focuses on understanding how system design and local energy conditions influence the Levelised Cost of Hydrogen (LCOH

In the ongoing library debate part of the focus has been on youth in libraries and how many libraries find them to be a challenging group to work with due to some occurring disturbances. In some cases the youth sections start to lean towards being youth recreation centers. Youth need somewhere to be that isn’t home or school and since there aren’t many open, free of cost public spaces, and many ci

Arbetet behandlar införandet av så kallade säkerhetszoner i Sverige och analyserar säkerhetszonerna ur ett rättssäkerhetsperspektiv. Säkerhetszoner möjliggör för polisen att genomföra kroppsvisitationer och fordonskontroller utan krav på konkret brottsmisstanke inom ett geografiskt avgränsat område. För-slaget om säkerhetszoner återfinns i det så kallade Tidöavtalet och har sedermera lett till lagThis thesis explores the legal implications of introducing so-called security zones in Sweden and analyzes them from a rule of law perspective. These zones allow police to conduct body searches and vehicle inspections without requiring specific criminal suspicion within designated geographic areas. Introduced as part of the Tidö Agreement (Tidöavtalet) and now legislated, security zones aim to com

Objectives This study investigated the association between cancer of the extrahepatic biliary tract and exposure to endocrine-disrupting compounds. Methods Altogether 183 men with histologically confirmed carcinoma of the extrahepatic biliary tract and 1938 matched controls were interviewed between 1995 and 1997 in the frame of an international multicenter case-control study in six European countr