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We here present the first genetic fine mapping of experimental autoimmune neuritis (EAN), the animal model of Guillain-Barre syndrome, in a rat advanced intercross line. We identified and refined a total of five quantitative trait loci on rat chromosomes 4, 10, and 12 (RNO4, RNO10, RNO12), showing linkage to splenic IFN-gamma secretion and disease severity. All quantitative trait loci were shared

Tasquinimod is an orally active antiangiogenic drug that is currently in phase III clinical trials for the treatment of castration-resistant prostate cancer. However, the target of this drug has remained unclear. In this study, we applied diverse strategies to identify the histone deacetylase HDAC4 as a target for the antiangiogenic activity of tasquinimod. Our comprehensive analysis revealed allo

Context:Patients with treated adrenal insufficiency (AI) have increased morbidity and mortality rate. Our goal was to improve outcome by developing a once-daily (OD) oral hydrocortisone dual-release tablet with a more physiological exposure-time cortisol profile.Objective:The aim was to compare pharmacokinetics and metabolic outcome between OD and the same daily dose of thrice-daily (TID) dose of

There is a mounting effort to use nickel oxide (NiO) as p-type selective electrode for organometal halide perovskite-based solar cells. Recently, an overall power conversion efficiency using this hole acceptor has reached 18%. However, ultrafast spectroscopic investigations on the mechanism of charge injection as well as recombination dynamics have yet to be studied and understood. Using time-reso

Chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) is a protein that binds and blocks the C5a receptor (C5aR) and formylated peptide receptor, thereby inhibiting the immune cell recruitment associated with inflammation. If CHIPS was less reactive with existing human antibodies, it would be a promising anti-inflammatory drug candidate. Therefore, we applied directed evolution and comput

Physical activity is beneficial for the health of persons with disabilities but the levels of such activity are lower than for persons without disability. In addition the level of physical activity decreases with increasing age. For persons aging with a disability it may be a challenge to engage in physical activity, partly because of the disability and partly because of contextual barriers. One g

Background: Degraded extracellular matrix can stimulate the innate immune system via the Toll-Like Receptor-4 (TLR4). In the pancreas, syndecan-anchored heparan sulphate (HS) on the ductal epithelium can be cleaved off its protein cores by the proteases (trypsin and elastase) and potentially activate TLR4 signalling. Methods: To investigate this signalling event, a low sulphated HS (500 mu g/ml) w

Syftet med Dublinförordningen är att se till att asylansökningar behandlas av endast en medlemsstat, för att undvika fenomenen “asylsum shopping” och “refugees in orbit”. Förordningen består av en hierarki av kriterier för att fastställa vilken stat som är ansvarig, men detta har också lett till principen om ömsesidigt förtroende mellan medlemsstaterna, där alla stater förutsätts ha samma nivå av The purpose of the Dublin Regulation is to ensure that applications for asylum will be considered by one Member State, avoiding the phenomena of “asylum shopping” and “refugees in orbit”. The Regulation consists of a hierarchy of criteria for determining the responsible state, however, this has also resulted in the principle of Mutual Trust between Member States, where all states are presumed to h

Dendritic cells (DC) are the most potent APC in the organism. Immature dendritic cells (iDC) reside in the tissue where they capture pathogens whereas mature dendritic cells (mDC) are able to activate T cells in the lymph node. This dramatic functional change is mediated by an important genetic reprogramming. Glycosylation is the most common form of posttranslational modification of proteins and h

Context:The cardiac natriuretic peptides are involved in blood pressure regulation, and large cross-sectional studies have shown lower plasma levels of N-terminal pro-natriuretic peptide levels [N-terminal atrial natriuretic peptide (N-ANP) and N-terminal brain natriuretic peptide (N-BNP)] in patients with insulin resistance, obesity, and diabetes.Objective:In this study, we prospectively tested w

Recent investigations of core-shell nanowires using synchrotron radiation techniques deduced the average structural parameters of heterostructure core-shell nanowires. Here, we report on first results and discuss the problems arising when measuring such complex nanostructures by using nanofocusing X-ray techniques. InAs/IAsP core-shell nanowires exhibit a certain bending, the origin of which is de

Knut Hamsun (1859-1952) is generally regarded as one of the first proponents of modern literature in Scandinavia. The present thesis discusses the author’s breakthrough phase which took place around the year 1890. This was an era when societal modernity became established in the Scandinavian countries, and new and revolutionary ideas and norms appeared concerning society, science, and art. Hamsun

Total levels of circulating prostate-specific antigen (tPSA) are strongly associated with prostate cancer (PCa) risk and outcome but benign prostate disease is the most frequent cause of a moderately elevated PSA level. Free PSA (fPSA) forms are independently associated with PCa risk and contribute modest diagnostic enhancements above and beyond tPSA alone. We developed an immunoassay for fPSA sub

Senior lecturer Contact details Email: vincent [dot] hedberg [at] fysik [dot] lu [dot] se Phone: +46 46 222 39 17Organisation Particle and nuclear physics Service point: 14 WebpageVincent Hedbergs profile in Lund University research portalI am a lecturer and the project leader at CERN for a small detector project called LUCID in ATLAS. You can find more details about my activities in my homepage a

https://www.particle-nuclear.lu.se/vincent-hedberg - 2026-06-16

Identifying and characterizing young stars in the Solar neighbourhood is essential to find and describe planets in the early stages of their evolution. This work seeks to identify nearby young stars showing a lithium 6708 Å absorption line in the GALAH survey. A robust, data-driven approach is used to search for corresponding templates in the pool of 434 215 measured dwarf spectra in the survey. I

BACKGROUND: Stereotypes may prevail, but little is known about the influence that the sex of an orthopaedic surgeon may have on outcomes. In a recently published study, there were no differences in the rate of adverse events following total hip arthroplasties (THAs) performed by female or male orthopaedic surgeons. The objective of the present study was to investigate whether there was any differe

Integrated development environments (IDEs) increase programmer productivity, providing rapid, interactive feedback based on the syntax and semantics of a language. A heavy burden lies on developers of new languages to provide adequate IDE support. Code generation techniques provide a viable, efficient approach to semi-automatically produce IDE plugins. Key components for the realization of plugins

This chapter provides a physical background to the following ones. It describes the particle and wave properties of light and the diffraction, polarization, refraction, reflection, and absorption of light and statistics of photon emission and absorption. Planck’s law of heat radiation is described in various mathematical and graphical ways. One section is devoted to a simplified description of the