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Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene

Variations in the POLG1 gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma, have recently been associated with Parkinson's disease (PD), especially in patients diagnosed with progressive external ophthalmoplegia (PEO). However, the majority of the studies reporting this association mainly focused on the genetic identification of the variation in POLG1 in PD patient prima

The solvability and subellipticity of systems of pseudodifferential operators

The paper studies the local solvability and subellipticity for square systems of principal type. These are the systems for which the principal symbol vanishes of first order on its kernel. For systems of principal type having constant characteristics, local solvability is equivalent to condition (Ψ) on the eigenvalues. This is a condition on the sign changes of the imaginary part along the oriente

Bringing Morality Back : Three Interviews

This chapter presents three interviews with three influential voices in the field of social movement and civil society studies, namely, those of Doug McAdam, Jeffrey Alexander, and Nina Eliasoph. They all share their perspectives on social movements’ role in society’s moral development, the role of morality internally in social movements, and the role of morality for social science as a practice.

Managers’ understanding of agile in hardware development

The agile methodology is gaining attention among practitioners and researchers in hardware development. As a new methodology, it is a source of misunderstandings and misinterpretations. This is problematic at the managers' levels as they may hinder its adoption or lead to its impractical implementation and use. This study, therefore, aims to explore the manager's level of understanding of the agil

Detection of Inflammasome Activation in Murine Bone Marrow-Derived Macrophages Infected with Group A Streptococcus

Inflammasomes are large multiprotein complexes that assemble mainly in innate immune cells after detection of microbial or sterile insults. Activation of inflammasomes is a key proinflammatory event during infection, and many pathogens have evolved specific evasion mechanisms to evade or inhibit inflammasome activation. One such pathogen is the common bacterium group A Streptococcus (GAS), which c

Long Proofs of (Seemingly) Simple Formulas

In 2010, Spence and Van Gelder presented a family of CNF formulas based on combinatorial block designs. They showed empirically that this construction yielded small instances that were orders of magnitude harder for state-of-the-art SAT solvers than other benchmarks of comparable size, but left open the problem of proving theoretical lower bounds. We establish that these formulas are exponentially

Development of a Molecular Imprinting-Based Surface Plasmon Resonance Biosensor for Rapid and Sensitive Detection of Staphylococcus aureus Alpha Hemolysin From Human Serum

Stapylococcus aureus is a common infectious agent in e.g. sepsis, associated with both high mortality rates and severe long-term effects. The cytolytic protein α-hemolysin has repeatedly been shown to enhance the virulence of S. aureus. Combined with an unhindered spread of multi drug-resistant strains, this has triggered research into novel anti virulence (i.e. anti α-hemolysin) drugs. Their func

Relationship between water quality and macro-scale parameters (land use, erosion, geology, and population density) in the Siminehrood River Basin

To date, few studies have investigated the simultaneous effects of macro-scale parameters (MSPs) such as land use, population density, geology, and erosion layers on micro-scale water quality variables (MSWQVs). This research focused on an evaluation of the relationship between MSPs and MSWQVs in the Siminehrood River Basin, Iran. In addition, we investigated the importance of water particle trave

Engaging with the general public on critical raw materials through the medium of electronics repair workshops.

The issue of Critical Raw Materials (CRMs) and potential interruptions to their supply andavailability due to concerns such as shortages, trade restrictions or geopolitical considerations are topicsthat are relatively unknown to the general public. Education and the dissemination of this informationamongst the general public has been promoted as a key factor in addressing this and enabling thetran

4-quinolone antibiotics : Positive genotoxic screening tests despite an apparent lack of mutation induction

The effects of different 4-quinolone antibiotic derivatives (4-Qs) in a number of short-term tests commonly employed for the evaluation of genetic toxicity were studied. Incorporation of [3H]thymidine into mitogen-stimulated peripheral blood lymphocytes was strongly enhanced at a low concentration (1.56 μg/ml) for most of the tested 4-Qs, whereas DNA strand breakage in lymphoblastoid cells was evi

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This thesis explores the name, naming and naming politics in three poetic texts which exhibit a concern with the normative force of language: Cristina Peri Rossi’s Evohé (1971), Julia Álvarez’ The Other Side/El otro lado (1995) and Ana Arzoumanian’s (2006) Juana I. In Evohé the woman-body and the woman-word collide and penetrate each other; in The Other Side/ El otro lado the English code conflict

Some theoretical and numerical aspects of the N-body problem

The N-body problem has been studied for many centuries and is still of interest in contemporary science. A lot of effort has gone into solving this problem but it's unlikely that a general solution will be found with the mathematical tools we have today. We review some of the progress that has been made over the centuries in solving it. We take a look at the first integrals, existence of solut

Underlåtenhet att avslöja våldtäkt - En åskådares skyldighet att agera eller en möjlighet att undkomma ansvar?

Bestämmelsen om underlåtenhet att avslöja våldtäkt har sällan åberopats i praktiken. Under 2017 prövades brottet av Högsta domstolen vars dom har tolkats i ett annat våldtäktsmål. Uppsatsens huvudsakliga syfte är att analysera de objektiva förutsättningarna för straffbarhet för åskådare vid underlåtenhet att avslöja våldtäkt samt analysera hur bestämmelsen tillämpas i praktiken. Med det avses såväThe provision regarding failure to reveal an ongoing rape has seldom been invoked in court. However, the crime was tried by the Swedish Supreme Court in 2017 and the judgment has been interpreted in another case of rape. The main purpose of the essay is to analyze the objective prerequisites for criminal responsibility regarding spectators in the event of failure to reveal an ongoing rape. This en

Plan för globalt dynamiskt engagemang – färdplaner 2026. Beslut 2025-12-11. Ikraftträdande 2026-01-0

Plan för globalt dynamiskt engagemang – färdplaner 2026 FÖRSÄTTSSIDA STYRDOKUMENT Plan för globalt dynamiskt engagemang – färdplaner 2026 Typ av styrdokument: Plan Definition av typen av styrdokument: Planer innehåller konkreta åtgärder som behövs för att mål i exempelvis strategier och policyer ska uppnås, kan innehålla en sammanställning av aktiviteter som tillsammans ska leda till att uppnå mål

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2026-01/plan-for-gde-fardplaner-2026.pdf - 2026-06-22

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Centre for East and South-East Asian Studies Course literature for COSB40 Contemporary South-East Asia - Political Developments and Societal Issues 7.5 ECTS. Required Reading listed here: 839 Additional Reading reserved for new developments: 150 Total: 989 All readings are available on Finn unless otherwise stated Aban, Ananeza (2025). Rediscovering the Sacred Among Agrarian Societies: The Tara Ba

https://www.ht.lu.se/media/utbildning/dokument/kurser/COSB40/20262/COSB40_Literature_2026_Final_.docx - 2026-06-16

29_Memory Work-Line Palle Andersen-LTH_mod

29_Memory Work-Line Palle Andersen-LTH_mod LTHs 10:e Pedagogiska Inspirationskonferens, 6 december 2018 Abstract— At a Danish University College we arranged one week of online teaching during each of three consecutive semesters where students in groups had to design their own learning programme based on online educational resources. Frigga Haug’s methodology Memory Work was adjusted to classroom t

https://www.lth.se/fileadmin/lth/genombrottet/konferens2018/C1_Andersen.pdf - 2026-06-09

PAOlsson

PAOlsson LTHs 6:e Pedagogiska Inspirationskonferens, 15 december 2010 Abstract— The aim of this study was to evaluate the students learning through an inquiry survey connected to the excursion and follow-up lecture course. Students were asked what they remembered from the excursion and from the follow-up classroom lecture, and how this connected to their different senses. The students considered a

https://www.lth.se/fileadmin/lth/genombrottet/konferens2010/25_Olsson.pdf - 2026-06-09

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LUND UNIVERSITY Department of Archaeology and Ancient History Reading list – ARKN30, Theory, method and ethics on advanced level, 15 credits Approved by the Department Board: 260609 Unless otherwise stated, literature is searched for in FINN. General handbook: Cipolla, Craig N., Rachel J. Crellin, and Oliver JT Harris (eds). (2024) Archaeology for today and tomorrow. London: Routledge Archaeologic

https://www.ht.lu.se/media/utbildning/dokument/kurser/ARKN30/20262/ARKN30_Literature_list_260609.pdf - 2026-06-11