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The present disclosure relates to compositions, constructs and vectors for reprogramming cells into plasmacytoid dendritic cells or interferon type I-producing cells, methods and uses thereof. The present disclosure relates to the development of methods for making plasmacytoid dendritic cells or interferon type I-producing cells that promote antiviral and anti-tumoral immune responses from differe
The article critically addresses the 'allegiance' test developed by International Criminal Jurisdictions for the determination of protected personal status under the Fourth Geneva Convention. Through a deconstruction of its elements and the methodology employed in its creation, the author shows substantial and methodological flaws that showcase the test as highly questionable example of judicial l
The share of couples where the wife out-earns the husband is increasing in manycountries. In this paper, I investigate how this income dynamic affects mental health.Using data on all Swedish couples who married in 2001, I show that mental health ispositively associated with own and spousal income. However, it is negatively linked tothe wife’s relative income. Crossing the threshold where the wife
Transcriptomic and proteomic profiling classify bladder cancers into luminal and basal molecular subtypes, with controversial prognostic and predictive associations. The complexity of published subtyping algorithms is a major impediment to understanding their biology and validating or refuting their clinical use. Here, we optimize and validate compact algorithms based on the Lund taxonomy, which s
Ground penetrating radar (GPR) is a well-established technique used in archaeological prospection and it requires a number of specialized routines for signal and image processing to enhance the data acquired and lead towards a better interpretation of them. Computer-aided techniques have advanced the interpretation of GPR data, dealing with a wide range of operations aiming towards locating, imagi
Objective: Arterial stiffness is independently associated with orthostatic hypotension (OH) in older individuals. The relationship between orthostatic blood pressure (BP) and arterial stiffness has not been thoroughly examined in the younger population. To investigate the relationship between orthostatic BP adaptations, central aortic hemodynamics, and arterial stiffness in the general population
Ammonia (NH3) is a promising carbon-free energy carrier. Co-firing of ammonia in solid fuel-fired facilities is a feasible solution to reduce carbon dioxide (CO2) emissions. Solid fuels, such as coal and biomass, contain various trace elements, such as alkali metals and sulfur, which are released to the gas phase during combustion. Experimental characterization and modeling are used to study the p
This chapter explores the desk as a material object as well as its sym- bolic representations in social work from a professional perspective. As we will demonstrate, different and sometimes incompatible meanings and functions associated with the desk reflect current tensions and profession- al dilemmas: On the one hand, ever since the emergence of the social work profession, the desk has symbolize
Risk management has reduced vulnerability to floods and droughts globally1,2, yet their impacts are still increasing3. An improved understanding of the causes of changing impacts is therefore needed, but has been hampered by a lack of empirical data4,5. On the basis of a global dataset of 45 pairs of events that occurred within the same area, we show that risk management generally reduces the impa
BACKGROUND: Two studies that examined the interaction between HLA-DRB1 and smoking in Parkinson's disease (PD) yielded findings in opposite directions.OBJECTIVE: To perform a large-scale independent replication of the HLA-DRB1 × smoking interaction.METHODS: We genotyped 182 single nucleotide polymorphism (SNPs) associated with smoking initiation in 12 424 cases and 9480 controls to perform a Mende
Arbuscular mycorrhizal fungi (AMF) are important in plant nutrient uptake, but their function is prone to environmental constraints including soil factors that may suppress AMF transfer of phosphorus (P) from the soil to the plant. The objective of this study was to disentangle the biotic and abiotic components of AMF-suppressive soils. Suppression was measured in terms of AMF-mediated plant uptak
As a state where the ruling communist party operates in a central planning mode, the policies of the ruling party and central government exert a great influence on national affairs with a long historical tradition in China, which can be even more obviously illustrated in the issues of climate change. But on the other hand, there is still no specific national climate legislation in China, which is
The interactions between oppositely charged multi-indented lock- and spherical key-particles are investigated by means of Monte Carlo simulations at low volume fractions. The specificity of the interactions is initially investigated in an excess of either lock- or key-particles, and we find ordered clusters with highly directional bonds. This suggests electrostatics alone to be capable of inducing
