Filtyp
The paper presents a new global modeling tool, Stratospheric Chemical Transport Model 2. It has been developed for effective three-dimensional multiyear stratospheric chemistry studies, featuring an extensive chemistry scheme, heterogeneous processing on sulfate aerosols, and some polar stratospheric cloud processes. The transport algorithm maintains sub-grid-scale distributions and connects verti
A new scientific view of evolution is emerging—one that challenges and expands our understanding of how evolution works. Recent research demonstrates that organisms differ greatly in how effective they are at evolving. Whether and how each organism adapts and diversifies depends critically on the mechanistic details of how that organism operates—its development, physiology, and behavior. That is b
Lysine acetylation, once viewed primarily as a histone mark, is now recognized as a widespread regulator of protein function. Recent breakthroughs in chemical labeling, isotopic tagging workflows, and data-independent acquisition mass spectrometry enable precise, site-specific quantification of acetylation stoichiometry. This quantitative “acetylomics” approach reveals a “rheostat” model, where mo
October is coming to an end as we release this sixth and last episode of the first season (not to worry, we are already planning a second season). This time Nic and Rebecca have invited Paul McMillan to the mic and chat with him about our galaxy, the Milky Way, and his involvement in ESA's Gaia satellite . Thereafter they take a closer look at the Pleiades.
Hazardous situations involving radioactive, chemical, and other dangerous materials pose significant risks to emergency responders. In such situations, robots can support civil forces in reconnaissance and mitigation. However, this requires the development of robotic systems with novel AI-based assistance functions, operation procedures, and raises new ethical and legal questions. To address these
Background: Ageing-in-place policies have increasingly shifted elder care responsibilities onto family members. Among older cohabiting couples, one’s partner’s illness significantly impacts the other’s daily life and well-being.Aim: To explore the responsibilities and strategies of caregiving partners in older cohabiting couples from the perspectives of cohabiting caregivers.Methods: A qualitative
Inhibition of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is under increasing investigation for its therapeutic potential in many diseases. Existing AMPK inhibitors are however limited, with poor selectivity and substantial off-target effects. Here, we provide mechanistic insights and describe the cellular selectivity of the recently identified AMPK inhibitor BAY-3827. A 2.5-Å
The Iberian ribbed newt (Pleurodeles waltl) constitutes a central model for probing the basis of vertebrate regeneration. Here, we present the sequencing and chromosome-scale assembly of the 20.3Gb P. waltl genome, which exhibits the highest level of contiguity and completeness among giant genome assemblies. We uncover that DNA transposable elements are the major contributors to its expansion, wit
Green ammonia synthesis from nitrogen via photocatalysis and electrocatalysis has emerged as a pivotal research focus in sustainable chemical processes. The efficient catalytic reduction of nitrogen necessitates concurrent nitrogen activation and hydrogen evolution suppression, representing a significant challenge. In this study, CuAu bimetallic-modified TiO2 catalysts were developed and engineere
This article explores the complex relationship between performance programs in higher music education and the evolving demands of current and future professional music scenes. Drawing upon career anchor theory and enactive cognitive science, it introduces a workshop-based framework to support students in reflecting on future working life. The framework decenters ideas of entrepreneurship and marke
Let (Formula presented.) be a (Formula presented.) -adic analytic pro- (Formula presented.) group of dimension (Formula presented.), with lower (Formula presented.) -series (Formula presented.). We produce an approximate series which descends regularly in strata and whose terms deviate from (Formula presented.) in a uniformly bounded way. This brings to light a new set of rational invariants (Form
UNLABELLED: Systemic targeted therapy in prostate cancer is primarily focused on ablating androgen signaling. Androgen deprivation therapy and second-generation androgen receptor (AR)-targeted therapy selectively favor the development of treatment-resistant subtypes of metastatic castration-resistant prostate cancer (mCRPC), defined by AR and neuroendocrine (NE) markers. Molecular drivers of doubl
The Large Hadron Collider (LHC) at CERN became operational in 2009 and has since then produced a plethora of physics results from proton–proton (pp) collisions. This short review covers results that relate to soft quantum chromodynamics (QCD) with a focus on nondiffractive physics at midrapidity. Most of the presented results are based on transverse momentum spectra and related derived observables
The current paper focuses on the conceptual design and numerical analysis of a four-stage centrifugal pump for the fuel system of a turbofan engine with liquid hydrogen as fuel. Liquid hydrogen is challenging at high pressures due to its special fluid properties. The design condition for the pump is set at take-off, to raise the pressure of liquid hydrogen from 6 bars at the outlet of a low-pressu
This special issue deals with temporalities in migration law with particular emphasis on the European context. At the crossroads of several legal fields, including public law, human rights law, EU law and public international law, the topic is cutting-edge in migration law. The articles collected were originally presented at a conference organized at Vrije Universiteit in Amsterdam in June 2023 an
Historically, research on nonavian reptile communication has emphasized visual, tactile, and chemical modalities. Recently, growing evidence highlights the significance of acoustic signals in intra- and interspecies interactions. Reptiles produce sounds to mediate social behaviors such as reproduction, parent–offspring interactions, and territorial defense. Many species were found to have diverse
Adolescents and young adult comprise a significant proportion of India’s population. Although, this group of the population faces serious challenges to their health and well-being. To promote their health and well-being, Centre of Excellence (CoE) at King George’s Medical University, Lucknow, India, serves as an advanced care facility for 10–24-year-old adolescents and young adult women. This pape
