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Telomere attachment to the nuclear envelope (NE) is a prerequisite for chromosomemovement duringmeiotic prophase I that is required for pairing of homologous chromosomes, synapsis, and homologous recombination. Here we show that Speedy A, a noncanonical activator of cyclin-dependent kinases (Cdks), is specifically localized to telomeres in prophase I male and female germ cells in mice, and plays a

We study the chemical evolution of Zr, La, Ce, and Eu in the Milky Way discs and bulge by means of chemical evolution models compared with spectroscopic data. We consider detailed chemical evolution models for the Galactic thick disc, thin disc, and bulge, which have been already tested to reproduce the observed [α/Fe] versus [Fe/H] diagrams and metallicity distribution functions for the three dif

Tuberculosis, is caused by various strains of Mycobacteria, and specifically the one by Mycobacterium tuberculosis needs effective treatment. Administration of antibiotics fails owing to multi-drug resistant capability of Mycobacterium. Traditional methods for the identification of a potential drug take time and require huge investment The present study was focused on virtual screening to identify

There is a great need for targeted protein assays with the capacity of sensitive measurements in complex samples such as plasma or serum, not the least for clinical purposes. Proteomics keeps generating hundreds of biomarker candidates that need to be transferred towards true clinical application through targeted verification studies and towards clinically applicable analysis formats. The immunoaf

Significant efforts are ongoing to develop refined differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells (PSCs) for application in disease modeling, diagnostics, drug screening, and cell-based therapies for Parkinson's Disease (PD). An increased understanding of the timing and molecular mechanisms promoting the generation of distinct subtypes of human mid

Acoustic discrimination of speech sounds is affected by various factors, ranging from more universal acoustic properties of categories to the phoneme systems of the native language and dialect, and even influences from languages learned later in life. A discrimination experiment containing East Central Swedish vowels was carried out with 30 native Swedish listeners in order to explore the variatio

In this work, we investigate properties of intermediate-mass black holes (IMBHs) that escape from star clusters due to dynamical interactions. The studied models were simulated as part of the preliminary second survey carried out using the MOCCA code (MOCCA-SURVEY Database II), which is based on the Monte Carlo N-body method and does not include gravitational wave recoil kick prescriptions of

This paper argues that Sámi reindeer pastoralism in Sweden is highly stressed during the critical snow cover periods due to large-scale human interventions, especially forestry, and that these have over time significantly worsened the ecological conditions for natural grazing-based responses to changing snow conditions caused by climate change. Informed by a literature review, the paper conceptual

This study acknowledges that home is a central and valenced place for most people, and therefore it is assumed that (a) the content in people’s general category for home issues can be activated easily, particularly by various home-related stimuli, and that (b) the affective charge of such content can have a valence-congruent impact on evaluations of home-related stimuli. These assumptions were the

Divine sovereignty (ḥākimiyya)—as conceived by Abū al-A‘lā Mawdūdī (1903–79) and popularised by Sayyid Quṭb (1906–66) - has been a central component of Islamist thought. This article investigates the reception of the concept within Shi‘i Islam. As case studies, the article choses two prominent actors in the formative period of Shi‘i Islamism in Iraq: Muḥammad Bāqir al-Ṣadr (1935–80) and Muḥammad T

This chapter explores the circulation, use and public discussion of images of human foetuses travelling from the US to Sweden in the period before and after the introduction of abortion on demand in Sweden in 1975. In this period, new antiabortion groups formed and started to use graphic images of aborted foetuses in their campaigns. This chapter highlights the transnational and transmedial charac

Monitoring insects of different species to understand the factors affecting their diversity and decline is a major challenge. Laser remote sensing and spectroscopy offer promising novel solutions to this. Coherent scattering from thin wing membranes also known as wing interference patterns (WIPs) have recently been demonstrated to be species specific. The colors of WIPs arise due to unique fringy

A probability assignment technique for weighting-based double exponential data in lossless image compression is introduced. It is shown that this technique has a favorable effect on compression when compared with traditional estimation techniques.

AIMS: The present study sought to determine predictors for success and outcomes of patients who underwent cardiac implantable electronic devices (CIED) extraction indicated for systemic or local CIED related infection in particular where complete lead removal could not be achieved.METHODS AND RESULTS: ESC-EORP ELECTRa (European Lead Extraction ConTRolled Registry) is a European prospective lead ex

Traditionally tourists are treated as passive media consumers but this chapter departs from a performance perspective emphasizing tourists’ active role. This chapter deals with how popular music affects tourists’ experiences in destinations by exploring the performance of place-making practices by tourists as they engage with music. The performance perspective is complemented with a ritual perspec