Filtyp
The presence of serotonin (5-hydroxytryptamine [5-HT]) in pancreatic endocrine cells is well established. Nevertheless, recent advances are only now unraveling the signaling network involving 5-HT that partly regulates the release of hormones emanating from the islets of Langerhans. It is widely accepted that failure of the pancreatic β-cell to release sufficient amounts of insulin is the main cul
Digital healthcare services and digital health information, here called eHealth services, have the potential to reach people with diverse needs as both a complement to and a substitution for traditional healthcare. The access to and use of digital health information and digital healthcare services that are accessible and usable for people with impairments is a complex phenomenon.This potential is
We explore the transformative potential of SAM 2, a vision foundation model, in advancing gaze estimation. SAM 2 addresses key challenges in gaze estimation by significantly reducing annotation time, simplifying deployment, and enhancing segmentation accuracy. Utilizing its zero-shot capabilities with minimal user input—a single click per video—we tested SAM 2 on over 14 million eye images from a
The aim of this study is to examine Turkish nationalism in order to find what factors that play a part in Turkey's inability to confess and discuss such events as the Armenian Genocide, which took place between the years of 1915.-1923, by the fall of the Ottoman Empire. The factors found and examined closely are collective memory and the use of history. The paper is a case study of Turkey with
Syftet med denna uppsats är att belysa hur medvetna musiklärare är om jämställdhetsperspektivet i sin undervisning, om det finns skillnader mellan manliga och kvinnliga lärare och hur lärarna ser på de budskap och värderingar de förmedlar i sin undervisning ur ett jämställdhetsperspektiv. Undersökningen genomfördes på en skola med hjälp av observationer och kvalitativa intervjuer av berörda lärare
Daniel Quinn is the protagonist in Paul Auster's novel City of Glass. This essay traces his development chronologically to assess his search for, need of, and eventual lack of an identity.
In a Λ cold dark matter (ΛCDM) cosmology, the Milky Way accretes satellites into the stellar disc. We use cosmological simulations to assess the frequency of near disc plane and higher inclination accretion events, and collisionless simulations of satellite mergers to quantify the final state of the accreted material and the effect on the thin disc. On average, a Milky Way-sized galaxy has three s
METHODS: This was a multicentre, international, observer-masked, randomised controlled trial of people with diabetes and a hard-to-heal foot ulcer done in 32 specialist diabetic foot clinics in three countries (UK, Denmark, and Sweden). After a 4-week run-in period, those with a reduction in ulcer area of less than 50% were randomly allocated (1:1) by computer-generated, web-based randomisation (b
A group of 38 male workers at a secondary smelter (period of employment 2-35 years; median 10 years) was divided into two subgroups depending on bone-lead concentration, arranged as 19 matched pairs according to age, education and job level. The median concentrations for finger-bone lead (Bone-Pb) were 16 vs. 32 μg/g; for current blood-lead (B-Pb), 1.6 vs. 1.8 μmol/l; for retrospective peak blood-
This study examines the effects of teachable agents’ expressed self-efficacy on students. A total of 166 students, 10- to 11-years-old, used a teachable agent-based math game focusing on the base-ten number system. By means of data logging and questionnaires, the study compared the effects of high vs. low agent self-efficacy on the students’ in-game performance, their own math self-efficacy, and t
Houses are prominent in many taxes in the Netherlands. In this chapter we analyze the situation of Dutch housing taxation in local and national taxes. We show that both are intertwined because of the use of one value which is determined at the local level, but used at the national level as well. We briefly discuss the balance between local and national taxation in the Netherlands, the relatively l
Since the discovery of non-coding RNAs (ncRNAs) a new area has emerged in the field of biomarkers. NcRNAs are RNA molecules of different sizes that are transcribed as independent genes or as part of protein coding genes and are not translated, therefore they do not produce proteins. They have been classified accord-ing to their size and function and include micro RNAs (miRNAs), piwiRNAs (piRNAs),
We have recently considered the problem of tuning a static plant described by a differentiable input-output function, which is completely unknown, but whose Jacobian takes values in a known polytope of matrices: to drive the output to a given desired value, we have suggested an integral feedback scheme, whose convergence is ensured if the polytope of matrices is robustly full row rank. The suggest
To simplify the analysis of complex dynamical networks, we have recently proposed an approach that decomposes the overall system into the sign-definite interconnection of subsystems with a Positive Impulse Response (PIR). PIR systems include and significantly generalise input-output monotone systems, and the PIR property (or equivalently, for linear systems, the Monotonic Step Response property) c
Using near-infrared femtosecond absorption spectroscopy, we have determined the S-1 energies of the carotenoids spheroidene and rhodopin glucoside in LH2 complexes of purple bacteria. The S-1 energies in the LH2 complexes yield values of 13400 +/- 100 cm(-1) for spheroidene and 12550 +/- 150 cm(-1) for rhodopin glucoside, which are very close to the S-1 energies obtained for both carotenoids in so
One approach to assessing overall opinion polarity (OvOP) of reviews, a concept defined in this paper, is the use of supervised machine learning mechanisms. In this paper, the impact of lexical filtering, applied to reviews, on the accuracy of two statistical classifiers (Naive Bayes and Markov Model) with respect to OvOP identification is observed. Two kinds of lexical filters, one based on hyper
Focusing on Western tourism behind the Iron Curtain, this chapter introduces the main research questions addressed in the volume: firstly, how and why Eastern Europe became a tourist destination for citizens of the West; secondly, what impact this had on the development of a tourism industry in the Eastern bloc; and thirdly, to what extent the experiences of Western tourists in Eastern Europe infl
Cancer cells evade the immune system by downregulating antigen presentation. Although immune checkpoint inhibitors (ICI) and adoptive T-cell therapies revolutionized cancer treatment, their efficacy relies on the intrinsic immunogenicity of tumor cells and antigen presentation by dendritic cells. Here, we describe a protocol to directly reprogram murine and human cancer cells into tumor-antigen-pr
The technical development, involving digitalization, artificial intelligence, automation, and machine learning, can challenge the current tax system and consequently the means to finance public sector activities in several ways. If technology replaces labor, a tax base that is taxed relatively hard will be replaced by a tax base (capital) that generates less tax revenue, and consequently, less tot
