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Human IgE - What We Can Learn from Repertoire Studies and How We Can Use Them as Tools

Popular Abstract in Swedish Människans immunförsvar har utvecklats under miljontals år för att i bästa möjliga mån skydda oss från infektioner och det sköter i de allra flesta fall det jobbet utmärkt. Ibland händer det dock att någonting går fel och konsekvensen kan bli väldigt obehaglig eller till och med förödande för den drabbade. Allergiska reaktioner är ett utmärkt exempel på en sådan situatiAntibodies of the IgE isotype play a key role as the allergen recognizer in allergic disease, which today affects as much as a third of the population in the industrialized parts of the world. Despite this crucial role of IgE, our knowledge of IgE repertoires and how we can utilize the information hidden in monoclonal IgE to improve the quality of life of allergic patients, is limited. This thesis

Biomarker Discovery in Cancer and Autoimmunity using an Affinity Proteomics Platform - a Tool for Personalized Medicine

Identification of novel biomarkers for early diagnosis, prognosis, and treatment decision will be instrumental for improving disease outcome for patients suffering from complex diseases, such as cancer and autoimmune disorders. Within personalized medicine, the use of circulating biomarkers will allow clinicians to tailor medical treatment based on individual characteristics of each patient, using

The Coast as Arena for Swedish Modernity

The perspective in the paper is the coast as a place for health, leisure, and recreation, and it takes its examples from southern Sweden and the city of Malmö. In Malmö the coast has been an essential and integrated part of the city’s business and image for centuries. It has been utilised and physically re-moulded for different purposes. By looking at the city coast from these perspectives, it is

Substrate Control in Fed-Batch Cultivations Using a Model-Based Modification of a PI-Controller

A fedbatch process shows exponential growth under ideal conditions. To obtain good substrate concentration control it is necessary that the regulator can track an exponentially growing feed demand, and standard PI-control has to be supplemented with an estimated basic dosage to get reasonable control. However, an exponentially growing concentration error is impossible to avoid. An I-term could be

Clashing rationales when using art events for visual urban renewal

It is a well-established practice in European cities to use large-scale projects for the purpose of geographical branding. As a radical strategy, urban renewal projects are used for branding purposes. To communicate visions to internal and external stakeholders are essential to establish and legitimize processes of change and large investments and costs related to the project. The aim of the stud

Ad Utrumque : Does the Seal of Lund University Suggest a Preparation for Fighting the Evil Danes or a Preparation to Consider the Opposing Viewpoint?

Ad utrumque (paratus), latin for “prepared for both”, is the motto of Lund University. When the University was founded in 1666 its primary mission was to secure the southern provinces of Scania to the Swedish king. Scania had previously belonged to Denmark, but the peace settlement of 1658 made them part of Sweden. The seal of the university also shows the carolingian lion reading a book while hol

Proton Induced X-rays and Gamma Rays for the Analysis of Welding Fumes

Welding aerosols have been sampled in different size fractions using a moving stage cascade impactor. Sampling has been done for different welding methods and for varying welding parameters. The elemental composition of the different size fractions have been determined by Proton Induced X-ray Emission, PIXE, combined with a nuclear method for fluorine analysis. Results show maximum mass of most el

Building a map of the breast cancer proteome - Strategies to increase coverage

Popular Abstract in Swedish Uppsättningen av gener i DNA, genomet, kan betraktas som drivande för konstruktionen av varje levande varelse, medan motsvarande proteiner, proteomet, är materiellt ansvariga för de flesta biologiska processer. Kort sagt, gener bestämmer vad celler ”ska kunna göra” medan proteiner definierar vad varje cell "gör" ur en funktionell synvinkel. Aktiviteten hos dessa molekylAmongst the various –omics sciences, proteomics has the highest potential for functional characterization and consequently can contribute significantly to the field of cancer research. In particular, the focus of this thesis is on breast cancer. Alas, since state-of-the-art technologies cannot meet the complexity of upper eukaryotic proteomes, a complete resolution of clinical samples is still una