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Evaluation of precipitation input for SWAT modeling in Alpine catchment : A case study in the Adige river basin (Italy)

Precipitation is often the most important input data in hydrological models when simulating streamflow. The Soil and Water Assessment Tool (SWAT), a widely used hydrological model, only makes use of data from one precipitation gauge station that is nearest to the centroid of each subbasin, which is eventually corrected using the elevation band method. This leads in general to inaccurate representa

Evaluation of eight high spatial resolution gridded precipitation products in Adige Basin (Italy) at multiple temporal and spatial scales

This study provides a comprehensive evaluation of eight high spatial resolution gridded precipitation products in Adige Basin located in Italy within 45–47.1°N. The Adige Basin is characterized by a complex topography, and independent ground data are available from a network of 101 rain gauges during 2000–2010. The eight products include the Version 7 TRMM (Tropical Rainfall Measuring Mission) Mul

Mapping the cell binding site on high molecular weight kininogen domain 5

Investigations mapped the region(s) on the light chain of high molecular weight kininogen (HK) that participates in cell binding. Sequential and overlapping peptides of domain 5 (D5(H)) were synthesized to determine its cell binding site(s). Three peptides from non-overlapping regions on D5(H) were found to inhibit biotin-HK binding to endothelial cells. Peptides GKE19 and HNL21 weakly inhibited b

Defining optimal dosing of ciprofloxacin in patients with septic shock

BACKGROUND: Patients with septic shock may undergo extensive physiological alterations that can alter antibiotic pharmacokinetics. OBJECTIVES: To describe the population pharmacokinetics of ciprofloxacin in septic shock and to define recommendations for effective ciprofloxacin dosing in these patients. METHODS: Adult patients with septic shock treated with ciprofloxacin were eligible for inclusion

Tidal stripping as a mechanism for placing globular clusters on wide orbits : The case of MGC1 in M31

The globular clusters of large spiral galaxies can be divided into two populations: one that formed in situ and one that comprises clusters tidally stripped away from other galaxies. In this paper, we investigate the contribution to the outer globular cluster population in the M31 galaxy through donation of clusters from dwarf galaxies. We test this numerically by comparing the contribution of glo

An Analysis of a Method to Estimate the Effect on Wind on Natural Ventilation in Large Spaces

The influence of wind is only occasionally accounted for in fire safety engineering, still the effect of wind on, for example, the performance of a smoke management system can be large. A simple analytical method to account for the effect of wind on mass flow through horizontal openings for natural ventilation is compared to results from CFD simulations in this paper. It is seen that the correspon

HAMLET, a protein complex from human milk has bactericidal activity and enhances the activity of antibiotics against pathogenic Streptococci

HAMLET is a protein-lipid complex derived from human milk that was first described for its tumoricidal activity. Later studies showed that HAMLET also has direct bactericidal activity against select species of bacteria, with highest activity against Streptococcus pneumoniae Additionally, HAMLET in combination with various antimicrobial agents can make a broader range of antibiotic-resistant bacter

Could Virtual Tourism of Augmented Reality (AR) reduce Greenhouse Gases?

This paper investigates how stakeholders respond to digital feasibility study images to augmented reality (AR), with the purpose to determine if AR could be the right practical application to create Virtual tourism. Based on the visitors’ perspective via qualitative interviews, the goal is to explore whether a digitalization in a realistic way, manages to mediate the concealed time layers and othe

Modelling and numerical simulation of remodelling processes in cortical bone : An IGA approach to flexoelectricity-induced osteocyte apoptosis and subsequent bone cell diffusion

Remodelling is an important process in bones in order to maintain bone mass and to recover cracks which naturally develop within the bone material. There is agreement in the literature that the piezoelectric characteristic of bones is one possible initiator of bone remodelling. In recent experimental studies, however, it has been found that cortical bone also exhibits flexoelectric properties whic

Prospects for detection of intermediate-mass black holes in globular clusters using integrated-light spectroscopy

The detection of intermediate-mass black holes (IMBHs) in Galactic globular clusters (GCs) has so far been controversial. In order to characterize the effectiveness of integrated-light spectroscopy through integral field units, we analyse realistic mock data generated from state-of-the-art Monte Carlo simulations of GCs with a central IMBH, considering different setups and conditions varying IMBH

Swedish public and private housing companies’ access to the capital market for financing energy renovation

The financing of energy efficiency measures and renovations is key to reaching energy efficiency targets for the housing sector. The purpose of this article is to add the Swedish case of how capital market funds have become accessible and used by public and private housing companies, in particular for energy efficiency measures. The core of this article are interviews with representatives of Swedi

A Multilevel Circular Economy Repair Society Model: Understanding system-wide implications of normalized product repair from the perspective of the Product User

Initiatives to upscale repair activities are becoming increasingly common, with the latestbeing the EU commission’s proposal to strengthen consumers’ right to repair. However, theseinitiatives are not viewed comprehensively, particularly not for how they impact the product user’sexperience of the repair process, and what type of repair conditions would emerge once fullyimplemented. This gap exists

Skin and wound delivery systems for antimicrobial peptides

Non-healing wounds cause hundreds of thousands of deaths every year, and result in large costs for society. A key reason for this is the prevalence of challenging bacterial infections, which may dramatically hinder wound healing. With resistance development among bacteria against antibiotics, this situation has deteriorated during the last couple of decades, pointing to an urgent need for new woun

The effects of Galactic model uncertainties on LISA observations of double neutron stars

Observations of binaries containing pairs of neutron stars using the upcoming space-based gravitational wave observatory, LISA, have the potential to improve our understanding of neutron star physics and binary evolution. In this work, we assess the effect of changing the model of the Milky Way’s kinematics and star formation history on predictions of the population of double neutron stars that wi