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The metabolic syndrome - What is it and how should it be managed?

A cluster of metabolic factors have been merged into an entity named the metabolic syndrome. Although the characteristics of this syndrome have varied over time the presently used definition was established in 2009. The presence of three abnormal findings out of five components qualifies a person for the metabolic syndrome: elevated waist circumference, elevated triglycerides, reduced high-density

Professional judgements in collaboration

Although intimate partner violence is far from a new problem in society, it has lately gained increased attention both by governments and by the research community. In 2007, the Swedish government issued an action plan for “combating men’s violence against women, violence and oppression in the name of honour and violence in same-sex relationships” (2007/08:39), which included a call for increased

Development of 7-Item Perceived Meaning of Activity in Housing (PMA-H-7) to Assess Opportunities for Meaningful Activities in the Supported Housing Context for People With Psychiatric Disabilities

People with psychiatric disabilities need to be able to express their views about their support, for example, the provision of meaningful activity in supported accommodation. Brief scales may be necessary to avoid strain and discomfort for this group. The aim was to develop a brief version of Perceived Meaning in Activity—Housing (PMA-H) and investigate its factor structure, internal consistency,

The state of water in non-ionic surfactant solutions and lyotropic phases : Oxygen-17 magnetic relaxation study

Water 17O longitudinal and transverse relaxation rates have been measured in aqueous solutions and mesophases of the non-ionic alkyl oligo(ethylene oxide) surfactants C12En (n = 4, 5, 8) over wide ranges of temperature and concentration. In addition, two reference systems have been investigated: high molecular weight poly(ethylene oxide) and the dimer 1,2-dimethoxy ethane. The relaxation data are

Bacterial attachment to uro-epithelial cells : mechanisms and consequences.

Microbial attachment to mucosal surfaces is a first step in mucosal infection. Specific interactions between microbial surface ligands and host receptors influence the distribution of microbes in their sites of infection. Adhesion has often been regarded as a sufficient end point, explaining tissue tropism and bacterial persistence at mucosal sites. Adherence, however, is also a virulence factor t

Epigenetic Age in Male Combat-Exposed War Veterans : Associations with Posttraumatic Stress Disorder Status

DNA methylation patterns change with age and can be used to derive an estimate of "epigenetic age," an indicator of biological age. Several studies have shown associations of posttraumatic stress disorder (PTSD) with worse somatic health and early mortality, raising the possibility of accelerated biological aging. This study examined associations between estimated epigenetic age and various variab

High-order harmonic generation in xenon : Intensity and propagation effects

We present experimental results on high-order harmonic generation in xenon, using a Nd:YAG laser (1064 nm). The harmonic generation efficiency is studied as a function of the laser intensity in the 1013 W/cm2 range. The harmonic conversion rates show a significant change of behavior when the medium becomes ionized (∼1013 W/cm2). This effect can be understood as the change of the nonlinear response

Identification of an endothelial cell binding site on kininogen domain D3

High and low molecular mass kininogen, two multidomain plasma proteins, bind to endothelial cells, platelets, and neutrophils in the intravascular compartment. The specific cell attachment site on their common heavy chain is mediated by domain-3, a cystatin-like structure with inhibitory capacity for papain-like proteinases (Jiang, Y., Muller-Esterl, W., and Schmaier, A. H. (1992) J. Biol. Chem. 2

Human monocytes and neutrophils store transforming growth factor-α in a subpopulation of cytoplasmic granules

Transforming growth factor-α (TGF-α) exerts several effects on target cells, such as neovascularization promotion and mitogenic signalling. Using immunoelectron microscopy, we show that monocytes and neutrophils, store TGF- α in cytoplasmic granules. In monocytes, TGF-α did not colocalize with components of peroxidase-positive granules or with albumin of secretory vesicles. Furthermore, no colocal

Endothelial cells expressing an inflammatory phenotype are lysed by superantigen-targeted cytotoxic T cells

The objective of this study was to investigate whether the superantigen staphylococcal enterotoxin A (SEA), which binds to HLA class II and T-cell receptor Vβ chains, can direct cytotoxic T cells to lyse cytokine-stimulated endothelial cells (EC). In addition, we wanted to determine whether SEA- primed cytotoxic T cells could be targeted to EC surface molecules as a means of a novel cancer immunot

Exploring sensory perception, appraisal and concern: An approach to support design activity

The fundamental first stage of product interaction is through sensory perception, which generates cognitive and affective experiences. Product perception through sensory feedback is a major component in the end user product appraisal that precedes the elicitation of product emotion. Sensory evaluation is connected to a set of concepts including appraisal, concern and goal oriented objective. The i

Recommended guidelines for reviewing, reporting, and conducting research on post-resuscitation care : The Utstein style

The aim of this report is to establish recommendations for reviewing, reporting, and conducting research during the post-resuscitation period in hospital. It defines data that are needed for research and more specialised registries and therefore supplements the recently updated Utstein template for resuscitation registries. The updated Utstein template and the out-of-hospital "Chain of Survival" d

Experimental evidence for low intra-pair cache pilfering rates in European nuthatches

European nuthatches, Sitta europaea, live all year in permanent pair-territories. In winter, hoarded food is an important food source. To measure the rate of cache pilfering within pairs, each member of six pairs was supplied with either white- or dark-shelled sunflower seeds which the birds cached. When each bird had cached some 100-300 seeds, the feeder was removed and the birds were monitored d