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Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without

Haptoglobin phenotypes have been shown in human medicine to be related to the prevalence of various diseases. Furthermore, abnormal glycosylation of haptoglobin has been reported as a consequence of liver disease, cancer and immunological disorders in man. To our knowledge, similar findings have not, so far, been reported in canine disease. The present paper describes a method for investigation of

We study close encounters involving massive main-sequence stars and the evolution of the exotic products of these encounters as common-envelope systems or possible hypernova progenitors. We show that parabolic encounters between low- and high-mass stars and between two high-mass stars with small periastrons result in mergers on time-scales of a few tens of stellar free-fall times (a few tens of ho

Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. Mice with H. pylori infection develop severe gastritis and atrophic changes in their stomachs after 6 months. We followed H. pylori -infected animals for 13 months to find out whether dysplasia, carcinoma or lymphoma developed. Six-week-old C57BL/6 mice were infected

We present high-resolution 4.6 mu m CO spectra of the circumstellar environments of two red supergiants (RSGs) that are potential supernova (SN) progenitors: Betelgeuse and VY Canis Majoris (VY CMa). Around Betelgeuse, (CO)-C-12 emission within +/-3 '' (+/-12 km s(-1)) follows a mildly clumpy but otherwise spherical shell, smaller than its similar to 55 '' shell in KI lambda 7699. In stark contras

The identification of proteins separated on two-dimensional gels is most commonly performed by trypsin digestion and subsequent matrix-assisted laser desorption ionization (MALDI) with time-of-flight (TOF). Recently, atmospheric pressure (AP) MALDI coupled to an ion trap (IT) has emerged as a convenient method to obtain tandem mass spectra (MS/MS) from samples on MALDI target plates. In the presen

Secretory lysosomes of natural killer (NK) cells combine storage, regulated secretion and lysosomal activity. We asked whether one could target exogenous proteins to the secretory lysosomes of NK-cells for final delivery into a tumor site upon degranulation. cDNAs for both soluble and transmembrane (tm) proteins were expressed in the human YT-Indy NK-cell line. Targeting of a soluble TNF receptor

The rapid progress in scanning probe microscopy (SPM) techniques in the last decade has induced an increasing need for manufacturing advanced SPM tips. One important case is conductive and transparent tips. For such tips, only a few techniques have been proposed. which are either expensive or have poor reproducibility. We here propose a simple and cheap sol-gel technique to prepare fibers with a s

The purpose of this paper is to examine current practices of load factor utilisation of road transport. An interview study of five shippers and two transport providers were conducted. The research shows that transport providers seem to work efficiently with operational practices to improve the load factor, but the load factor seems not to be highly prioritised when it comes to strategic decisions.

The article investigates the relationship between Sweden and the Ottoman Empire during the eighteenth century with a focus on the travelogue of Jacob Björnståhl.

I detta konferensbidrag beskriver jag ett exempel på hur IKT (Informations- och kommunikationsteknik) kan användas i litteraturundervisning på gymnasiet i Sverige på ett sätt som gör det möjligt för eleverna att bli mer aktiva producenter av kunskap i en flexibel inlärningsmiljö samtidigt som man främjar en globaliserad litteratursyn, särskilt vad gäller fransk litteratur, som går bortom nationensIn this paper I describe an example of how ICT (Information and communication technologies) can be used in teaching literature at upper secondary level in Sweden in a way that lets the pupils become more active producers of knowledge in a flexible learning environment and promotes a globalized view of literature, especially of French literature, which goes beyond the nation’s borders.

Context: Dopamine agonists are the treatment of choice for prolactinomas and symptomatic idiopathic hyperprolactinemia. However, the optimal treatment strategy and treatment duration is not clear in all details. Objective: The aim of the study was to assess the effect of dopamine agonist withdrawal in patients with idiopathic hyperprolactinemia and prolactinomas. Data Sources: PubMed, the Cochrane

Abstract is not available

By counting the number of upcrossings of the mean level by a stationary Gaussian process one can estimate the mean frequency of the process. If the mean level is unknown and estimated from the observed mean level, then this crossing estimator is more or less biased, depending on the length of the observation interval. It is shown that if the interval is at least two mean wavelengths, then the bias