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Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria

The activation of dendritic cells (DCs) by microbes is mediated by pattern recognition receptors including the Toll-like receptors (TLR). Bacterial lipopolysaccharide acts via TLR4 whereas peptidoglycan and lipoprotein responses are mediated by TLR2. It is generally accepted that TLR binding to microbes occurs at the cell surface but this has not been directly demonstrated for human DCs. We show h

Securitising sovereignty? States, refugees, and the regionalisation of international law

At first sight, international law seems to uphold both state sovereignty and individual sovereignty. The existence and autonomy of a state are secured by the obligation on other states to respect its territorial integrity and the prohibition on intervening in other states’ domestic affairs. At the individual level, internationally guaranteed human rights serve comparable functions: they secure a m

The life and death of bees in an emerging knowledge for sustainability

The following text addresses the ecological and cultural significance of the threats affecting the honey-bee, and which are becoming apparent through the unusual and sometimes drastic death rates of bee colonies. General research conducted on this problem largely agrees that the threats to bees are a syndrome that has a multifactorial nature and anthropogenic origin. In face of a plethora of relev

Broken technologies : the humanist as engineer : an Introduction

There are many possible definitions of “technology” and I will discuss some of these in this book. However, in this introduction let me use a definition of Svante Lindqvist who defines technology very intuitively as “those activities, directed towards the satisfaction of human wants, which produce change in the material world.” He says also “the distinction between human “wants” and more limited h

Touchdowns in winespeak: ontologies and construals in use and meaning-making

The aim is to analyze wine descriptions in a lexical semantic framework that is capable of accounting for generalizations and explanations of use and meaning-making in general as well as in text genres such as wine tasting notes. The model is Lexical meaning as ontologies and construals (Paradis 2005), LOC for short, within the broader framework of Cognitive Semantics. Two touchdowns are made. The

Tobacco smoke as a major source of endotoxin in indoor air

Mass spectrometry was used to determine the endotoxin (lipopolysaccharide, LPS) marker 3-hydroxytetradecanoic acid and 3-deoxy -D-manno-2-octulosonic acid in cigarette tobacco and smoke particles. Tobacco from cigarettes of different brands purchased in four different countries in Europe and Asia contained similar amounts of LPS. Indoor exposure to environmental tobacco smoke (ETS) in rooms of smo