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Application of concurrent engineering (CE) to machinery has to consider the type of production (individual, serial), product complexity and level of design. Product development (PD) involves four characteristic levels of design that requires specific activities. The characteristic design levels require definitions of the activities for providing the necessary software and other support for all pha

The Wee1 cell cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependent kinases. Chemical inhibitors of Wee1 are currently being tested clinically as targeted anticancer drugs. Wee1 inhibition is thought to be preferentially cytotoxic in p53-defective cancer cells. However, TP53 mutant cancers do not respond consistently to Wee1 inhibitor treatment, indicating the exi

SummaryThe human pathogen Streptococcus pyogenes (GAS) causes both superficial infections, such as strep throat, and invasive infections, such as necrotizing fasciitis, and is responsible for about half a million deaths each year. The number of GAS infections have increased since the 1980’s, due to the emergence of a M1T1 strain that has become widely disseminated. Increased expression of Streptol

Due to phonemic restoration, listeners can reliably perceive words when a phoneme is replaced with noise. The cost associated with this process was investigated along with the effect of lexical uniqueness on phonemic restoration, using data from a lexical decision experiment where noise replaced phonemes that were either uniqueness points (the phoneme at which a word deviates from all nonrelated w

Refugees have moved into the spotlight of public debate in Europe and North America, where they are targeted by multiple welfare state interventions. This volume analyses the tensions that emerge within the strong welfare states of Northern Europe when faced with an increased immigration of protection-seeking people. Examining the encounter between refugees and the welfare states, this book explor

Japan’s decision to end it contribution to the U.N.’s top gender equality body could hardly come at a worse time, both diplomatically and symbolically.

The effort to electrify society has in recent years resulted in major changes in the transportation sector. Charging time remains a challenge in several applications such as transportation and heavy machinery. A proposed solution that shortens the energy replenishment time and adds flexibility in loading the grid is to battery-swapping: exchanging the depleted battery for a fully charged one. In s

BACKGROUND: Existing conceptions of teaching quality assume that classroom interactions serve as the foundation for effective teaching. The resulting data necessitates analytical approaches capable of extracting the semantics of these interactions.AIM: This study investigates whether and to what extent lesson semantics provide insights into teaching quality (i.e., cognitive engagement, encourageme

This paper provides a historical overview of the United Nations Framework Convention on Climate Change Conference of the Parties meetings and reviews the major outcomes of the meetings up to the most recent, which took place in Dubai. We describe how climate negotiations, agreements and policies have evolved, summarise the main points reached, and highlight the key concerns of low-income countries

We investigated the role of cultural experience in the search advantage for happy faces. European British participants living in the UK, Asian Japanese participants living in Japan, and Asian Japanese participants living in the UK, were required to search for a happy or an angry face target against a background of neutral facial expressions, using Asian Japanese and European American faces. Result

We study the geometric significance of Leinster’s magnitude invariant. For closed manifolds we find a precise relation with Brylinski’s beta function and therefore with classical invariants of knots and submanifolds. In the special case of compact homogeneous spaces we obtain an elementary proof that the residues of the beta function contain the same geometric information as the asymptotic expansi

This chapter takes an interest in the construction of gendered knowledge in the digital space. Through an analysis of the digital activism of the epistemic agent Nadia Murad, survivor of the genocide against the Yazidi, the chapter investigates how she departs from her personal, embodied experience of ISIS violence to advocate for justice, recognition and reparation. Through the methodological app

The linearly polarized photon beam for photonuclear researches has been produced at MAX-lab facility on the base of coherent bremsstrahlung process of electrons in a diamond crystal. Test experiments have been performed at electron energies 143.9 and 192.7 MeV with a diamond crystal 0.1 mm thick. The measured coherent bremsstrahlung spectra demonstrate typical features to be observed at higher ele