Filtyp
The Human Variome Project (HVP) is a world organization working towards facilitating the collection, curation, interpretation and free and open sharing of genetic variation information. A key component of HVP activities is the development of standards and guidelines. HVP Standards are systems, procedures and technologies that the HVP Consortium has determined must be used by HVP-affiliated data sh
Recently, the anticancer activity of human a-lactalbumin made lethal to tumor cells (HAMLET) has been linked to its increased membrane affinity in vitro, at neutral pH, and ability to cause leakage relative to the inactive native bovine alpha-lactalbumin (BLA) protein. In this study, atomic force microscopy resolved membrane distortions and annular oligomers (AOs) produced by HAMLET when deposited
To probe internal motions in proteins on the 10−8−10−5 s time scale by NMR relaxation, it is necessary to eliminate protein tumbling. Here, we examine to what extent magnetic relaxation dispersion (MRD) experiments on the water 1H resonance report on protein motions in this time window. We also perform a critical test of two physically distinct mechanisms that have been proposed to explain and int
The normal flora furnishes the host with ecological barriers that prevent pathogen attack while maintaining tissue homeostasis. Urinary tract infections (UTIs) constitute a highly relevant model of microbial adaptation in which some patients infected with Escherichia coil develop acute pyelonephritis, while other patients with bacteriuria exhibit an asymptomatic carrier state similar to bacterial
Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists.
Adsorption of mixed polymer solutions in good solvent containing polymers of different chain length has been studied by applying simulation techniques on a coarse-grained bead-spring polymer model. Fully flexible polymers at varying bead-surface interaction strength and different combinations of flexible, semiflexible, and stiff polymers at a single bead-surface interaction strength have been exam
This book provides a number of studies of different aspects of Swedish child language. Some of the thematic chapters present original, unpublished data: on the acquisition of tense, on the range and frequency of different word order patterns in early child Swedish, related to the input, meaning the language of adults talking to the children or in the presence of the children. The remaining chapter
The intention of this chapter is neither a pure methodological nor a theoretical discussion, but instead, an empirical analysis which aims to understand variations in perceptions of global risks and environmental concern in a number of countries. The discussion, however, relies on methodological as well as theoretical perspectives concerning the shortcomings and pitfalls one encounters in comparin
Abstract is not available
There are many possible definitions of “technology” and I will discuss some of these in this book. However, in this introduction let me use a definition of Svante Lindqvist who defines technology very intuitively as “those activities, directed towards the satisfaction of human wants, which produce change in the material world.” He says also “the distinction between human “wants” and more limited h
The popular image of archaeology and what archaeologists do is based on various clichés which emphasise, among other things, adventurous fieldwork, the discovery of treasures and historical detective work. Although archaeologists may see themselves differently, their image in popular culture reveals a lot about how the subject is perceived and why it is so widely appreciated at present. I suggest
On death dying and disposal in contemporary Sweden.
