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BACKGROUND: Heparin-binding protein (HBP) is a neutrophil-derived pro-inflammatory protein, an inducer of endothelial dysfunction and vascular permeability and a promising prognostic biomarker in sepsis. This exploratory study aims to describe the kinetics of plasma HBP during septic shock and investigate an association between repeated measures of HBP concentration and cardiovascular organ dysfun

In the concluding chapter, we outline the major findings from the eleven book chapters by connecting them to one another. We come back to the triadic delegation and accountability relationship between candidates, voters and parties that were developed based on principal–agent theory, and emphasise the most relevant findings of this book that inform this triad. The chapter also takes a critical sta

We present the widespread Ewald summation method in a new light by utilizing a truncated Gaussian screening charge distribution. This choice entails an exact formalism, also as particle mesh Ewald, which in practice is not always the case when using a Gaussian screening function. The presented approach reduces the number of dependent parameters compared to a Gaussian and, for an infinite reciproca

Group A Streptococcus is a common pathogen that elicits a protective humoral response against the cell wall component GlcNAc. In this issue of Immunity, New et al. demonstrate the ability of long-lived B-1 cells to be programmed by microbial colonization and early life immunization to uniquely incorporate GlcNAc reactivity in mice, establishing their critical role in mediating neonatal immune impr

Since its publication and first performance, Edward Albee’s Who’s Afraid of Virginia Woolf? (1962) has often been interpreted with regard to the theme of truth and illusion. A less studied but nonetheless important aspect of the play concerns its relation to C. P. Snow’s concept of the “two cultures.” This article argues for the convergence of these two discussions, resulting in an epistemological

Every day, throughout the world, people put huge quantities of food out at feeding stations for birds and other wild animals.Although we know that connecting with nature benefits human health and wellbeing, scientists still know relatively little about the consequences of providing food for wildlife. My team’s most recent research, however, has found that feeding garden birds in wintertime seems t

Introduction The relationship between the right to freedom of expression and the prevention of terrorism is particularly fraught. On the one hand, in climates and contexts where there is a heightened risk of terrorist activities being perpetrated, States' authorities often argue that it is necessary to restrict freedom of expression. The reasons presented vary from the need to criminalize inciteme

Introduction The Universal Declaration of Human Rights includes all categories of human rights in one and the same instrument. The same approach has been followed in many subsequent human rights treaties, including, for example, the Convention on the Rights of the Child (CRC) and the African Charter on Human and Peoples’ Rights (African Charter). However, the two Covenants of 1966 – the Internatio

Several findings link proteinase 3 (PR3) to small vessel vasculitis. Besides being a major target of anti-neutrophil cytoplasm antibodies (ANCA), previous findings have shown increased circulating levels of PR3 in vasculitis patients, increased levels of neutrophil membrane-PR3 (mPR3) expression and a skewed distribution of the − 564 A/G polymorphism in the promotor region of the PR3 gene. In this

To determine the extent the World Health Organization (WHO) guidelines on the care of Low Birth Weight (LBW) newborns are followed in Pakistani hospitals and analyze any difference in policy compliance between different hospitals.

Popular Abstract in Swedish Olyckor i järnvägssektorn kan ge upphov till katastrofala konsekvenser. I första hand kan människors liv och hälsa drabbas, men allvarliga konsekvenser kan även uppstå för samhället i stort. Detta beror på att järnvägssystemet, liksom en rad andra infrastruktursystem är väsentliga för att vårt moderna samhälle ska fungera. Under de senaste decennierna har dessa system bIn recent decades, the Swedish railway system has faced substantial deregulations. As a result, management of risk is often carried out in settings involving multiple stakeholders having various roles, mandates, and viewpoints on risk, and where no single stakeholder has the superior authority. In order to manage risks in this type of multi-actor setting, the traditional elements of risk assessmen

Type 1 diabetes involves the specific destruction of the pancreatic islet β-cells, eventually resulting in a complete dependency of exogenous insulin. The clinical onset of diabetes is preceded by the appearance of autoantibodies against β-cell antigens. The human leukocyte antigen (HLA) region is the single most important genetic determinant of Type 1 diabetes susceptibility, yet variability in t

This paper explores the bearing had by Aymara notions of spirit loss on contemporary indigenous discourses of colonialism and decolonization and discusses the dynamics of cross-fertilization between “traditional” curing practices and cosmology on the one hand and indigenous ethnopolitical activism and discourse on the other.

Mysticism can be regarded as an integral element of religion. It includes both a way of life and a direct consciousness of the presence of God. Broadly defined as such, one can encounter mystical dimensions within all religions of the world. In order to alter consciousness, mystics in different traditions use a variety of techniques – different types of meditation, visualisation, repetitive prayer

An improved nonlinear asymptotic theory of spiral density waves is developed. It extends the theory developed by Yuan & Kuo to a global theory, not just one limited to the vicinity of the resonance. It can then be applied to the recent high-resolution observations of CO and HST NICMOS of nearby spiral galaxies. As an example, we apply the theory to the nearby grand-design spiral galaxy NGC 524