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Pulse transformer size is fundamentally linked to application pulselength, pulse power and pulse rise time. In considering long-pulse high-power applications, it has earlier been demonstrated that the large voltage-time integral associated with long-pulse operation in combination with the severe pulse rise time required to ensure high pulse efficiency strictly limits the number of transformer wind
Objective: Although targeted approaches have become available in second- and third-line settings, platinum-based chemotherapy remains the standard first-line treatment for advanced muscle-invasive bladder cancer (MIBC). Therefore, the prediction of platinum resistance is of utmost clinical importance. Methods: In this study, we established a routine compatible method for the molecular classificati
Oat (Avena sativa L.) is an important and nutritious cereal crop, and there is a growing need to identify genes that contribute to improved oat varieties. Here we utilize a newly sequenced and annotated oat reference genome to locate and characterize quantitative trait loci (QTLs) affecting agronomic and grain-quality traits in five oat populations. We find strong and significant associations betw
Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery.
An established negative association between socio-economic status (SES) and divorce has applied to most Western nations since 1960. We expected a positive association between SES and divorce for low-divorce contexts historically because only individuals in higher social strata had the resources to overcome barriers to divorce. According to Goode’s socio-economic growth theory, this relationship wa
Willingness to pay (WTP) for booster doses of coronavirus disease 2019 (COVID-19) vaccines is an under studied research topic. Therefore, the current study aimed to investigate the WTP for the booster doses of COVID-19 vaccines and its predictors in Indonesia using an online survey distributed all over the provinces of this low-middle-income country. The WTP was evaluated using a basic dichotomous
The upcoming Cherenkov Telescope Array (CTA) ground-based gamma-ray observatory will open up our view of the very high energy Universe, offering an improvement in sensitivity of 5-10 times that of previous experiments. NectarCAM is one of the proposed cameras for the Medium-Sized Telescopes (MST) which have been designed to cover the core energy range of CTA, from 100 GeV to 10 TeV. The final came
Background: Rectal washout (RW) is routinely performed during anterior resection (AR) for rectal cancer to reduce local recurrence (LR), although is sometimes not performed during minimally invasive surgery (MIS) procedures due to technical challenges and time consumption. The aim was to investigate the impact of RW on the oncological outcome after AR for rectal cancer in a registry cohort. Method
This paper presents a scoping review of methods for fire evacuation training in buildings. It adopts the PRISMA methodology (Transparent Reporting of systematic Reviews and Meta-Analyses) and systematically identifies 73 sources among scientific literature published between 1997 and 2022. It was found that the literature is dominated by research on modern technology (Augmented Reality, Virtual Rea
Tissue clearing is commonly used for whole-brain imaging but seldom used for brain slices. Here, we present a simple protocol to slice, immunostain, and clear sections of adult rat brains for subsequent high-resolution confocal imaging. The protocol does not require toxic reagents or specialized equipment. We also provide instructions for culturing of rat brain slices free floating on permeable cu
The spatial distribution of elemental abundances and their time evolution are among the major constraints to disentangling the scenarios of formation and evolution of the Galaxy. Aims. In this paper we used the sample of open clusters available in the final release of the Gaia-ESO survey to trace the Galactic radial abundance and abundance-to-iron ratio gradients, and their time evolution. Methods
The Soil and Water Assessment Tool (SWAT) model has been widely applied for simulating the water cycle and quantifying the influence of climate change and anthropogenic activities on hydrological processes. A major uncertainty of SWAT stems from the poor representation of vegetation dynamics due to the use of a simplistic vegetation growth and development module. Using long-term remote sensing-bas
Background: Incisional hernia is one of the most common complications after laparotomy. The aim of this retrospective study was to investigate incidence, location and risk factors for incisional hernia after open resection for colorectal liver metastases including the use of perioperative chemotherapy and targeted therapy evaluated by computed tomography. Methods: Patients operated for colorectal
Climate change is an important new challenge for local authorities. This study analyses the potential for using the Swedish mandatory process for risk and vulnerability analysis (RVA) as a vehicle to improve local climate adaptation work. An advantage with RVA is its comprehensive approach in dealing with all relevant threats and all vital functions of society. In order to test the applicability o
This article presents a new method for localization of multiple concurrent speech sources that relies on simultaneous blind signal separation and direction of arrival (DOA) estimation, as well as a method to solve the intersection point selection problem that arises when locating multiple speech sources using multiple sensor arrays. The proposed method is based on a low complexity non-parametric b
Cancer is one of the leading causes of death worldwide, but reliable diagnosis and staging can contribute to optimal treatment planning, and is a crucial factor in reducing mortality and maintaining quality of life. Soft tissue mechanical properties are promising indicators of cancer that can be assessed non-invasively using functional imaging. Additionally, lymphatic involvement is considered a k
Background: Alpha-synuclein (asyn) has been shown to play an important role in the neuropathology of Parkinson's disease (PD). In the diseased brain, classic intraneuronal inclusions called Lewy bodies contain abnormal formations of asyn protein which is mostly phosphorylated at serine 129 (pS129 asyn). This suggests that post-translational modifications may play a role in the pathogenic process.
The budding yeast Naumovozyma castellii (syn. Saccharomyces castellii) has been included in comparative genomics studies, functional analyses of centromere DNA elements, and was shown to possess beneficial traits for telomere biology research. To provide useful tools for molecular genetic approaches, we produced stable haploid heterothallic strains from an early ancestral strain derived from the N
An applied kHz optical remote sensing system is implemented to determine the flight direction of an insect with respect to wind direction, and its relative size using near- and shortwave infrared light in situ.
