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Background and aims: Gambling disorder (GD) is a behavioral addiction often co-occurring with various mental health concerns, such as problematic pornography use (PPU). The specific impact of the co-occurrence of GD and PPU on treatment outcome remains underexplored. This study aimed to compare the treatment outcomes of individuals actively receiving treatment for GD (n = 172; 3.49% females), dist
The human brain is a complex and finely tuned organ, constantly monitored and maintained by its resident immune cells.Among these, microglia are the primary regulators of the brain immune environment under physiological conditions, and monocyte-derived macrophages contribute mainly to pathological states such as ischemic stroke and neuronopathic Gaucher’s disease (GD). These two diseases, although
Parkinson's disease (PD) is characterized by a set of motor symptoms that depend on nigrostriatal dopaminergic degeneration and respond well to pharmacological dopamine replacement using L-DOPA. However, replacing dopamine with either L-DOPA or dopamine receptor agonists leads to the appearance of motor and nonmotor complications within a few years. Strong emphasis is currently placed on developin
Antibody-based microarrays have emerged as an established proteomic technology allowing multiplexed and sensitive profiling of complex proteomes, in a high-throughput and miniaturized manner. Recently, numerous applicative efforts have been pursued generating disease-associated protein signatures that now could be further explored for improved disease diagnostics, prognostics and classification.
Popular Abstract in Swedish Vår arvsmassa består av en cirka två meter lång tråd av DNA. Denna långa DNA-tråd är väl hoppackad och alla kärnbärande celler i kroppen har en kopia av den. Tråden kan delas upp i korta segment som utgör våra gener och mellanliggande segment vars uppgift inte är helt klarlagd. Totalt har vi enligt nuvarande beräkningar cirka 30 000 gener. Dessa gener, som innehåller koThe aim the thesis work was to study the human cystatins C, E/M, F, G, H and I both in vivo and in vitro. A mouse devoid of cystatin C was used for the cystatin C studies. The levels of cystatins C, E/M and F were measured in pleural effusion samples of patients with various lung disorders. Cystatin F protein and RNA levels were measured in the human haematopoietic cell line U937 as well as in cel
Popular Abstract in Swedish Parkinsons sjukdom är en relativt vanlig kronisk neurologisk sjukdom som karaktäriseras av att nervceller i ett specifikt område djupt i hjärnan av okänd anledning successivt dör. Dessa celler producerar signalsubstansen dopamin, vilken bl a är nödvändig för normal rörelseförmåga. Motoriska symptom (skakningar, muskelstelhet, förlångsammade rörelser och balansstörningarThis explorative study aimed to apply, develop, and evaluate assessment methods at various levels in cell replacement therapy for Parkinson’s disease (PD). Observed motor effects in five grafted patients support that timed motor tasks and clinical ratings of parkinsonism are able to monitor motor function, but their psychometric properties need further attention. Using positron emission tomograp
This thesis is a comparative study of the communist past as depicted in Czech and German feature films since 1989, or ‘reel socialism’. It is the first detailed study of post-1989 Czech history films and the first comparative study of German post-reunification cinema. It demonstrates that cinema has been a vehicle of similar sense-making processes in the two history cultures. Much of the research
Patienter som vårdas på intensivvårdsavdelningen (IVA) är kritiskt sjuka. Inter-nationella samt nationella studier visar på att många patienter kan efter att ha vårdats på IVA, få psykiska besvär så som ångest, depression och posttraumatisk stress (PTSD). En bidragande faktor för att utveckla dessa besvär har visat sig vara obehagliga och traumatiska minnen. Syftet med studien var att beskriva pat
Real-time 3D reconstruction is crucial for immersive AR/VR but is hard to achieve with traditional photogrammetry and mesh-based pipelines due to latency and limited scalability. Neural Radiance Fields (NeRF) enable high-quality novel view synthesis but suffer from long training and slow rendering, while Gaussian Splatting (GS) achieves real-time rendering at the cost of heavy preprocessing and me
Background Breast cancer is the most frequently diagnosed cancer in women. Survival is generally considered favourable, yet some patients remain at risk of early death. We aimed to assess whether comprehensive whole-genome sequencing (WGS) linked to mortality data could add prognostic value to existing clinical measures and identify patients who might respond to targeted therapeutics. Methods In t
Microbial bio-aroma synthesized from biowaste, and its marketing is an emerging aspect of future research due to their benefits. However, the sensory lexicon of bio-aroma has not yet been developed so far. This study aims to identify the smell characteristics of bio-aroma produced by fermentative yeast Kluyveromyces marxianus by solid-state fermentation, where the sample was extracted from ferment
This chapter explores key developments in international tax law amid the digitalization of the global economy. It examines challenges in taxing multinational enterprises (MNEs) and the OECD’s reform efforts under “Pillars One and Two”. The current tax system, designed for a pre-digital era, struggles to capture revenue from digital businesses, enabling profit shifting to low-tax jurisdictions and
Coffee is epidemiologically linked to health benefits and risks. Coffee is thought to be a diuretic. However, it can still contribute to daily fluid intake. Vasopressin is the most important physiological regulator of body fluid balance and diuresis. This study aimed to map the effects of coffee intake on vasopressin concentration. In the population-based cross-sectional Malmö Offspring Study (n =
Incels definieras som de individer vilka lever i ett ofrivilligt celibat, men innefattar även en delad världsuppfattning. Deras världsuppfattning kan kort beskrivas inneha offermentalitet, beskyllande av omgivningen samt kvinnofientlighet. Då vi funnit kunskapsluckor i forskningen gällande hur incels uttrycker och skapar gruppsammanhållning, såväl som hur de förhåller sig till maskulinitetsnormer,
This research examines what was at stake for young Chinese women who are negatively conceptualized as fudimo 扶弟魔. Drawing on feminist theories of everyday resistance and relational autonomy, it explores how they resist intersecting gendered power relations in everyday life. The thesis draws on ethnographic methods, including participant observation and semi-structured interviews with 15 women aged
