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188Re-ZHER2:V2, a promising affibody-based targeting agent against HER2-expressing tumors : preclinical assessment

UNLABELLED: Affibody molecules are small (7 kDa) nonimmunoglobulin scaffold proteins with favorable tumor-targeting properties. Studies concerning the influence of chelators on biodistribution of (99m)Tc-labeled Affibody molecules demonstrated that the variant with a C-terminal glycyl-glycyl-glycyl-cysteine peptide-based chelator (designated ZHER2:V2) has the best biodistribution profile in vivo a

Listening across Borders : Global Considerations for Listening and Public Diplomacy

Listening in public diplomacy is a rather new topic in academic discussions. Early public diplomacy scholarship was dominated, and in large degree continues to be dominated, by a focus on crafting messages and influencing. The more recent focus on relationship management and collaborative public diplomacy allowed for discussions about another role for listening. Yet, as some scholars pointed out,

Medical methods and Patentability of Nanomedicine in Europe: small matter, large interrogations

The present article was presented at the ATRIP Congress 2015. The main question addressed is whether reinterpretation, reformulation or replacement of Article 53 (c) of the European Patent Convention is viable and advisable. The issue is addressed by reference to both novel and resurfacing interpretative concerns connected with emerging technologies exemplified by nanomedicine, but also considerin

Why Pashukanis was right : Abstraction and form in The General Theory of Law and Marxism

The area of Marxism and law has long been considered marginalised. However, hand in hand with the renaissance of Marxist theory in recent decades, neglect has finally been put to rest. As Marxists increasingly explore the connections between rights, law, democracy and capitalism, one text in particular has taken centre stage: The General Theory of Law and Marxism, published by E. B. Pashukanis in

Plasma calprotectin in the emergency department : a potential clinical biomarker for patients with infectious diseases

Increased levels of plasma calprotectin are reported in patients with infectious diseases. However, the clinical usefulness of calprotectin as a biomarker to identify patients with infectious diseases in the emergency department (ED) setting has not been investigated. To study the ability of calprotectin to discriminate patients with acute infectious diseases and dyspnea from patients with other c

Improved calibrations of TDR measurements using artificial neural networks

Time domain reflectometry (TDR) has been proven to take accurate readings of the apparent dielectricconstant Ka and bulk electrical conductivity σa. These measurements have been used for estimations ofwater content (θ) and concentration of different chemicals. The concentration of an ionic pollutant ortracer can be estimated from the soil solution electrical conductivity σw. Several different cali