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We have estimated affinities for the binding of 34 ligands to trypsin and nine guest molecules to three different hosts in the SAMPL3 blind challenge, using the MM/PBSA, MM/GBSA, LIE, continuum LIE, and Glide score methods. For the trypsin challenge, none of the methods were able to accurately predict the experimental results. For the MM/GB(PB)SA and LIE methods, the rankings were essentially rand
Judicial review, power exerted by supreme judicial bodies to examine constitutionality of the actions of the legislator and the executive and declare them void if they violate the constitution, is a powerful instrument in hands of judiciary. First introduced in the United States by the Supreme Court as a constitutional principle it has spread all over the world and has been widely exercised by suc
Human induced climate change i.e. global warming caused largely by greenhouse gas emission will change the ecological balance of our planet and lead to dramatic societal problems. Working Group 1 Contribution to the Forth Assessment Report of the IPCC, Climate Change 2007: The Physical Science Basis, 2007, p. 1-18 In the Arctic region, such changes are already occurring. The Inuit, an indigenous g
European Community (EC) Competition Law and Intellectual Property Right (IPR) share the same basic objective of promoting consumer welfare and allocation of resources. However, potential conflicts arise owing to the means used by each system to promote their respective goals. Tying and bundling is one of these means, which IPR owners use as one way to exploit Intellectual Property (IP). Competitio
The periodontal ligament (PDL) is a highly heterogeneous fibrous connective tissue and plays a critical role in distributing occlusal forces and regulating tissue remodeling. Its mechanical properties are largely determined by the extracellular matrix, comprising a collagenous fiber network interacting with the capillary system as well as interstitial fluid containing proteoglycans. While the phas
Oppenheimer describes The Act of Killing as a ‘documentary about the imagination. We are documenting the ways we imagine ourselves, the ways we know ourselves’. This research analyses the documentary films The Act of Killing (Director Oppenheimer, co-directors Christine Cynn and anonymous 2012) and The Look of Silence (director Oppenheimer 2014), and the documentary imaginary. The research combine
Since the turn of the century, agriculture in sub-Saharan Africa has been undergoing rapid transformation. Ghana is experiencing an agrarian revolution with increasing farmland sizes, increased mechanisation of production and external input usage, and high levels of commercialisation. In this paper we show the growth of farm sizes, the major drivers of increasing farm sizes, and emerging relations
As part of the Large Scale Biosphere-Atmosphere Experiment in Amazonia - Smoke, Aerosols, Clouds, Rainfall and Climate (LBA-SMOCC) campaign, detailed surface and airborne aerosol measurements were performed over the Amazon Basin during the dry to wet season from 16 September to 14 November 2002. Optical and physical properties of aerosols at the surface, and in the boundary layer (BL) and free tro
We are developing a prototype system for simultaneous digital breast tomosynthesis (DBT) and mechanical imaging (MI). MI maps the local pressure distribution during clinical exams, to distinguish breast abnormalities from the normal tissue. Both DBT alone, and MI when combined with digital mammography, have demonstrated the ability to reduce false positives; however, the benefit of combining DBT w
In 2020, almost all research labs in industry, academia, and the government were shut down for long periods of time by political leaders to control the spread of the coronavirus. We consider the “micro” and “macro” implications of ongoing coronavirus disruptions in scientific research and the dissemination and commercialization of that research. We have identified three key unanswered research que
The government of Kenya has committed to run on 100% renewable energy by 2030 as part of the new national development goals, and as a result, the country calls for the construction of additional energy plants. However, the construction of these energy plants have in many cases affected local communities who have been forced to relocate to other areas. As an example of this, the recent expansion of
While whole-rock Lu-Hf isotope analysis remains one of the only ways to obtain initial Hf isotope signatures of old mafic rocks, Hf isotope analyses of more robust accessory zircon in intermediate to silicic rocks have largely replaced whole-rock analyses during the last decade. This has led to a discrepancy in the amount of existing data from mafic and felsic lithologies. However, especially in m
Background: The number of people with cognitive impairment, including dementia, in the world is steadily increasing. Although the consumption of isoflavones and soy is associated with a reduced risk of cardiovascular disease, it might also be associated with cognitive impairment. The low number of studies investigating the association between soy/isoflavone intake and cognitive function warrant ad
Background: Physical inactivity is a main cause of childhood obesity which tracks into adulthood obesity, making it important to address early in life. Physical activity on prescription (PAP) is an evidence-based intervention that has shown good effect on physical activity levels in adults, but has not been evaluated in children with obesity. This project aims to evaluate the prerequisites, determ
At a time when international tourist arrivals hit a new record year on year, the result is increased conflicts and impacts worldwide. Tourism geography has thus never played a moreimportant role in bridging the gaps between qualitative and quantitative as well as human and physical sciences. Increased tourism pressure is likely to have adverse social and environmental effects in many destinations.
