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Genome-wide association (GWA) studies represent a powerful strategy for identifying susceptibility genes for complex diseases in human populations but results must be confirmed and replicated. Because of the close homology between mouse and human genomes, the mouse can be used to add evidence to genes suggested by human studies. We used the mouse quantitative trait loci (QTL) map to interpret resu
A simple analytical model for the link loss between two very low profile wireless body area network transceivers located at the same level on the human torso is presented. The model is based on the attenuation of the creeping waves on an elliptical approximation of the human torso. A good agreement between the model and the FDTD simulations on realistic heterogeneous phantoms of different age and
This thesis considers the ecological and evolutionary significance of seed and bud dormancy. First, I present theoretical support to the idea that seed dormancy may evolve as a strategy to reduce sib competition in temporally homogeneous environments. In this thesis, I also analyze two different processes that may give rise to parent-offspring conflicts in angiosperms, viz. seed germination and se
Popular Abstract in Swedish Wnt-5a-genens betydelse för bröstcellernas normala funktion och för uppkomsten av bröstcancer I min avhandling har jag studerat en i bröstcancersammanhang hittills föga undersökt gen, Wnt-5a. Benämningen Wnt har bildats genom en sammanslagning av "Wingless" (den första identifierade Wnt-genen som orsakar vinglöshet hos bananflugan) och "Int" (från "Integration site" föThe Wnt-5a gene encodes a secreted protein that regulates several normal processes in embryonic and adult tissues by as yet unknown mechanisms. Expression of Wnt-5a protein does not cause cell transformation, but it instead counteracts the effects induced by transforming Wnts. Inasmuch as Wnt-5a can activate the Wnt/beta-catenin signalling pathway, we performed experiments to determine whether mol
The ability to understand packaging and how it contributes to the establishment of efficient logistics and the creation of individualised values for consumers is becoming increasingly important. This licentiate thesis stresses the importance of applying a holistic view of packaging in order to be able to understand how to adapt the distribution channel to meet consumer demands. The study focuses o
The number of nanoparticle-based products on the market is expected to increase considerably during the coming decades. For this to happen a solid supply of high-quality nanoparticles is needed. For metal nanoparticles no large-scale manufacturing method exists today but production using spark discharge generation is believed to be one of the most suitable candidates. Spark discharge generation of
We present an argument for the deprioritization of subjective well-being and a prioritization of human needs within degrowth research. First, we discuss empirical evidence, methodological problems and theoretical shortcomings of subjective well-being concepts. While data for one country over time suggest a flattening of the happiness curve relative to GDP growth, cross country comparisons reveal t
These European Board of Anaesthesiology (EBA) recommendations for safe medication practice replace the first edition of the EBA recommendations published in 2011. They were updated because evidence from critical incident reporting systems continues to show that medication errors remain a major safety issue in anaesthesia, intensive care, emergency medicine and pain medicine, and there is an ongoin
Benthic-pelagic coupling is manifested as the exchange of energy, mass, or nutrients between benthic and pelagic habitats. It plays a prominent role in aquatic ecosystems, and it is crucial to functions from nutrient cycling to energy transfer in food webs. Coastal and estuarine ecosystem structure and function are strongly affected by anthropogenic pressures; however, there are large gaps in our
Masses of 52Co, 52Com, 52Fe, 52Fem, and 52Mn have been measured with the JYFLTRAP double Penning trap mass spectrometer. The isobaric multiplet mass equation for the T = 2 quintet at A = 52 has been studied employing the new mass values. No significant breakdown (beyond the level) of the quadratic form of the IMME was observed (). The cubic coefficient was 6.0(32) keV (). The excitation energies f
Measurement is increasingly at the centre of debates in African economic development. Some remarkable upward revisions of GDP, which are signs of statistical systems improving, caused the declaration of a statistical tragedy in Africa. This special issue evaluates the database for African economic development with articles on the quality of the data on GDP, health and education, poverty, labour, a
The dating of terrestrial impact craters and impact glasses that exhibit high degrees of mineralogical complexity can be problematic. However, if the maximum potential of the terrestrial impact crater record is to be realized, accurate and precise ages for crater-forming events are critical. Here we report a high-precision 40Ar/39Ar age for the Dellen impact structure, Sweden. Previous radio-isoto
Objective. Flexible neural probes are hypothesized to reduce the chronic foreign body response (FBR) mainly by reducing the strain-stress caused by an interplay between the tethered probe and the brain's micromotion. However, a large discrepancy of Young's modulus still exists (3-6 orders of magnitude) between the flexible probes and the brain tissue. This raises the question of whether we need to
Searches for new resonances decaying into two photons in the ATLAS experiment at the CERN Large Hadron Collider are described. The analysis is based on proton-proton collision data corresponding to an integrated luminosity of 3.2 fb−1 at s=13 TeV recorded in 2015. Two searches are performed, one targeted at a spin-2 particle of mass larger than 500 GeV, using Randall-Sundrum graviton states as a b
