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Popular Abstract in Swedish Oberoende av om det är i ett samhälle, datornätverk eller organen i en mänsklig kropp, så är behovet av kommunikation stort i en komplex miljö. Eftersom den komplicerade människokroppen är beroende av kommunikation för att reglera funktioner, skickas otaliga mängder signaler oavbrutet. För att signalerna skall vara meningsfulla så måste de kunna tas emot och behandlas. Intercellular communication is of crucial importance in regulating physiology and G-protein coupled receptors (GPCRs) have evolved as an important mechanism in this process. Of the approximately 800 human GPCRs, about 160 are still considered to be “orphan” receptors for which an endogenous ligand remains to be identified. Since an estimated 50% of all clinical drugs act on 30 known GPCRs, the rem

Since the 1990s, economic policy instruments have become increasingly important to Swedish climate policy. To understand the characteristics of current systems, this paper presents an analysis of the development of economic policy instruments since the 1950s, with a focus on Swedish industry. Since the introduction of energy taxation, industry has received preferential treatment in the interests

Empowerment has been a key conceptual underpinning of participatory health research (PHR), both as a set of processes that inform how partners and diverse stakeholders engage with each other, as well as a set of outcomes that contribute to improved health and social equity. The concept of empowerment is present in a number of characteristics of PHR as described in Position Paper No. 1 of the ICPHR

For some decades, feminist scholars have engaged with the new responsibilities that corporations assume to address gender inequalities, often critiquing forms of economic empowerment that ignore the significance of social reproduction. Recently, however, the idea of a business case for unpaid care and domestic work (UCDW) has caught traction, opening up new ways for businesses to showcase responsi

INTRODUCTION: Delay in diagnosis of posterior cortical atrophy (PCA) syndrome is common, and the lack of familiarity with assessment tools for identifying visual cortical dysfunction is a contributing factor. We propose recommendations for the approach to the evaluation of PCA clinical features during the office visit, the neuropsychological evaluation, and the research setting. A recommended scre

This paper presents direct searches for lepton flavour violation in Higgs boson decays, H → eτ and H → μτ, performed using data collected with the ATLAS detector at the LHC. The searches are based on a data sample of proton-proton collisions at a centre-of-mass energy s = 13 TeV, corresponding to an integrated luminosity of 138 fb −1. Leptonic (τ → ℓνℓ ντ) and hadronic (τ → hadrons ντ) decays of t

Heavy-flavour hadron production provides information about the transport properties and microscopic structure of the quark–gluon plasma created in ultra-relativistic heavy-ion collisions. A measurement of the muons from semileptonic decays of charm and bottom hadrons produced in Pb+Pb and pp collisions at a nucleon–nucleon centre-of-mass energy of 5.02 TeV with the ATLAS detector at the Large Hadr

ABSTRACT: BACKGROUND: The objective of this work is to obtain the correct relative DNA contents of chromosomes in the normal male and female human diploid genomes for the use at FISH analysis of radiation-induced chromosome aberrations. RESULTS: The relative DNA contents of chromosomes in the male and female human diploid genomes have been calculated from the publicly available international Human

Complementary measures for the assessment of patient thermoregulatory state, such as subjective judgement scales, might be of considerable importance in field rescue scenarios where objective measures such as body core temperature, skin temperature, and oxygen consumption are difficult to obtain. The objective of this study was to evaluate, in healthy subjects, the reliability of the Cold Discomfo

AIMS: Lipoprotein lipase (LPL) is a major regulator of triglyceride clearance. A genetic variant of the LPL gene on chromosome 8p22, Asn291Ser, has previously been associated with dyslipidaemia and an increased frequency of cardiovascular disease as well as familial disorders of lipoprotein metabolism. The aim of this study was to test whether the phenotypic expression of the LPL Asn291Ser variant

The C-terminal G3 domains of lecticans mediate crosslinking to diverse extracellular matrix (ECM) proteins during ECM assembly, through their C-type lectin (CLD) subdomains. The structure of the rat aggrecan CLD in a Ca(2+)-dependent complex with fibronectin type III repeats 3-5 of rat tenascin-R provides detailed support for such crosslinking. The CLD loops bind Ca2+ like other CLDs, but no carbo

Previous studies have suggested that depression increases the risk for diabetes and that this may be mediated through insulin resistance. The study aimed to analyze if self-rated symptoms of depression are related to insulin resistance among middle-aged and older Swedish women with features of the metabolic syndrome and being at risk for type 2 diabetes mellitus. We analyzed data from 1047 Swedish

Protein C inhibitor (PCI) and antithrombin (AT) are serine protease inhibitors (serpins) that are involved in the regulation of coagulation. Like other inhibitory serpins, PCI and AT adopt different structural conformations that are related to their functions. The cleaved, inactive form is a result of cleavage by a protease, and the latent form, which is also inactive, can arise due to a mutation

Climate and weather extremes are sporadically recurring events that may have major local or regional impacts on the society and the environment. These events are typically related to unusually high or low temperature, prolonged dry or wet conditions, heavy precipitation, or extreme winds. Extreme events are part of the overall climate and weather alongside average conditions and variability, and t

Social, ecological, and cultural impacts associated with the U.S. military in Hawaii are egregious. However, due to the historical oppressions and injustices to Hawaiians, the U.S. military maintains their hegemony by wielding a disproportionate decisive political and economic power. This study aims to explore perceptions of Native Hawaiian and non-native activists regarding the military impacts a

The peace accord between the government of Colombia and the FARC-guerrilla has caught the attention of the world, not least for its deliberate focus on gender and the inclusion of women in the peace process. This essay aims to investigate the relation between theoretical outlining guidelines presented within the IDDRS framework. As to the construction of Disarmament, Demobilization and Reintegrati

The Swedish Dementia Registry (SveDem) was developed with the aim to improve the quality of diagnostic work-up, treatment and care of patients with dementia disorders in Sweden.

A search for the Standard Model Higgs boson produced in association with a top-quark pair, , is presented. The analysis uses 20.3 fb(-1) of pp collision data at , collected with the ATLAS detector at the Large Hadron Collider during 2012. The search is designed for the decay mode and uses events containing one or two electrons or muons. In order to improve the sensitivity of the search, events are

The aim of this research was to explore the consumer behavior of international students in the context of the choice for a higher education institution abroad in order to gain insights on their interactions with different online media communication channels during their decision journey. Previous research discussed the increased use of the internet during the application process for universities a