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Clickable, hybrid hydrogels as tissue culture platforms for modeling chronic pulmonary diseases in vitro

Statement of Purpose: Many chronic pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD), are complex and poorly understood. While great progress has been made to elucidate the cellular and molecular pathways underlying these diseases, treatment options remain limited. The dynamic alterations in mechanical pr

Who is performing surgery in low-income settings: a countrywide inventory of the surgical workforce distribution and scope of practice in Sierra Leone.

Scope of practice and in-country distribution of surgical providers in low-income countries remains insufficiently described. Through a nationwide comprehensive inventory of surgical procedures and providers in Sierra Leone, we aimed to present the geographic distribution, medical training, and productivity of surgical providers in a low-income country.

Agreement with Collective Nouns in English

Popular Abstract in Swedish Kollektiva substantiv definieras som substantiv som trots att de är singulara till formen betecknar en grupp av individer och som kan uppträda tillsammans med singulara och plurala verb och pronomina ('it'/'they'). Avhandlingen beskriver variation i kongruens vid kollektiva substantiv i amerikansk, brittisk och australiensisk engelska. Denna variation ses i exemplen nedThis thesis concerns agreement with collective nouns in American, British and Australian English. It is based on material from newspaper corpora and spoken corpora. The findings suggest that dialectal, stylistic, diachronic, syntactic and semantic factors interact in the selection of singular and plural agreement. It was shown that there are differences between regional varieties, between speech a

Quantum Algorithms for the Approximate k-List Problem and their Application to Lattice Sieving

The Shortest Vector Problem (SVP) is one of the mathematical foundations of lattice based cryptography. Lattice sieve algorithms are amongst the foremost methods of solving SVP. The asymptotically fastest known classical and quantum sieves solve SVP in a $d$-dimensional lattice in $2^{\const d + \smallo(d)}$ time steps with $2^{\const' d + \smallo(d)}$ memory for constants $c, c'$. In this work, w

Privacy-enabled Recommendations for Software Vulnerabilities

New software vulnerabilities are published daily.Prioritizing vulnerabilities according to their relevance to the collection of software an organization uses is a costly and slow process.While recommender systems were earlier proposed to address this issue, they ignore the security of the vulnerability prioritization data.As a result, a malicious operator or a third party adversary can collect vul

In vivo anterior cruciate ligament strain behaviour during a rapid deceleration movement : Case report

The mechanism of anterior cruciate ligament (ACL) injury is still unclear. To gain this insight, knowledge of the mechanical behaviour of the healthy ACL during activities that may stress the ligament must be investigated in vivo. The goal of this research was to measure ACL strain in vivo during rapid deceleration, a sport type movement that has been previously shown to precede injuries to the AC

Salvage radiotherapy after radical prostatectomy : functional outcomes in the LAPPRO trial after 8-year follow-up

OBJECTIVE: Radical prostatectomy reduces mortality among patients with localized prostate cancer, however up to 35% of patients will experience biochemical recurrence, often treated with salvage radiotherapy. The objective of the study was to investigate long-term effects of salvage radiotherapy. METHODS: A prospective, controlled, non-randomized trial at 14 Swedish center's including 4,003 patien

False-positive recalls in the prospective Malmö Breast Tomosynthesis Screening Trial

Objectives: To evaluate the total number of false-positive recalls, including radiographic appearances and false-positive biopsies, in the Malmö Breast Tomosynthesis Screening Trial (MBTST). Methods: The prospective, population-based MBTST, with 14,848 participating women, was designed to compare one-view digital breast tomosynthesis (DBT) to two-view digital mammography (DM) in breast cancer scre

Association between obstructive sleep apnoea and cancer : a cross-sectional, population-based study of the DISCOVERY cohort

Objectives Nocturnal hypoxia in obstructive sleep apnoea (OSA) is a potential risk factor for cancer. We aimed to investigate the association between OSA measures and cancer prevalence in a large national patient cohort. Design Cross-sectional study. Settings 44 sleep centres in Sweden. Participants 62 811 patients from the Swedish registry for positive airway pressure (PAP) treatment in OSA, link

From Apocalyptic Demonization to Theological Responsibility

As the effects of climate change, political upheaval and ravaging war are palpable, apocalyptic images as well as the concept ‘apocalyptic’ are today regularly invoked in politics, popular culture and mass media. This essay ponders the potential dangers of the apocalyptic imaginary, especially its tendency to encourage idealization of one’s own community and demonization of the other. As carriers

Physical activity, sedentary time and breast cancer risk : a Mendelian randomisation study

Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast can

Genetic anticipation in Swedish Lynch syndrome families

Among hereditary colorectal cancer predisposing syndromes, Lynch syndrome (LS) caused by mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2 is the most common. Patients with LS have an increased risk of early onset colon and endometrial cancer, but also other tumors that generally have an earlier onset compared to the general population. However, age at first primary cancer varies wit

Secure ownership transfer for the Internet of Things

With the increasing number of IoT devices deployed, the problem of switching ownership of devices is becoming more apparent. Especially, there is a need for transfer protocols not only addressing a single unit ownership transfer but secure transfer of a complete infrastructure of IoT units including also resource constraint devices. In this paper we present our novel ownership transfer protocol fo

Impact of religion on understanding the world: development of tense and modality

This paper analyses an impact of religious practice on the development of the tense system, in particular the future tense. There have been rich typological studies on the tense, which reveal that a basic tense distinction is either past vs. non-past or past vs. present vs. future in most languages. From evolutionary/historical perspectives, the former case is older than the latter one, i.e. the f

Emotions towards wildlife: Implications for policy and management. Symposium introduction

Human appreciation of nature and natural elements is ubiquitous. The role of emotions in human relationships with nature has received increasing attention within environmental psychology, for example by employing constructs such as affinity with nature. Also, researchers are recognizing the importance of studying emotions for understanding human-wildlife interactions (Jacobs, 2009; Johansson &