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The nucleotide sequences of the variable region genes encoding five different human, high affinity antibodies, specific for the major neutralization determinant (AD-1) expressed by human cytomegalovirus glycoprotein B (gp58/116), have been determined. Three of the five heavy chain variable regions belonged to the small VHV-family, although they combined with a diverse set of light chains (V kappa
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The concept of brain plasticity covers all the mechanisms involved in the capacity of the brain to adjust and remodel itself in response to environmental requirements, experience, skill acquisition, and new challenges including brain lesions. Advances in neuroimaging and neurophysiologic techniques have increased our knowledge of task-related changes in cortical representation areas in the intact
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Antigens of the clinically important ABO and P1PK blood group systems are carbohydrate structures. Thus the underlying genes do not encode antigens directly but glycosyltransferases that add specific sugar molecules to selected precursor chains. The aim of this study was to investigate the transcriptional regulation of ABO and A4GALT, with an emphasis on interindividual differences. The up-and dow
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OBJECTIVE: To examine the effect of using a mitt during shortened constraint-induced movement therapy for patients in the subacute phase after stroke. SUBJECTS: Twenty-four patients with stroke (mean age 57.6 (standard deviation (SD) 8.5) years; average 7 weeks post-stroke) with mild to moderate impaired hand function. METHODS: The patients were randomized to mitt use or no mitt use on the less af
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What is matter? One of the major themes in Emanuel Swedenborg’s thinking is the relation between the material and the immaterial, body and soul. During all his life, as a scientist and a visionary, Swedenborg (1688–1772) pondered on these questions. How can we get knowledge about the invisible? The world beyond the scope of our senses? The issue here is to explain the cognitive foundation of his m
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Popular Abstract in Swedish Immunsystemet skyddar kroppen mot infektion. För att kunna skydda mot infektion krävs att immunsystemet är utrustat med kraftfulla biokemiska motmedel. Ett sådant motmedel är antikroppar. Antikroppar är proteiner som känner igen och specifikt binder till andra molekyler via en s k molekylbindande klyfta. När antikropparna har bundit in till en molekyl på t ex en bakteriPrimary infections and vaccination stimulates the immunesystem to produce memory cells that rapidly respond to reexposure of the same antigen. These memory responses are dependent on an adaptive type of immunity that sustains the reactivity of the immune system by long-lived memory immune cells. From an evolutionary perspective adaptive immunity as such appears to be restricted to jawed vertebrate
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This thesis argues that general subordinators, such as the Germanic THAT and IF, denote propositional modality. Propositional modality stands for the “speaker’s attitude to the truth-value or factual status of the proposition” (Palmer 2001:24) and is otherwise expressed by moods such as the indicative-subjunctive and epistemic-evidential modal markers. One obvious connection between markers of pro
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A fracture risk assessment tool (FRAX (TM)) is developed based on the use of clinical risk factors with or without bone mineral density tests applied to the UK. Introduction The aim of this study was to apply an assessment tool for the prediction of fracture in men and women with the use of clinical risk factors (CRFs) for fracture with and without the use of femoral neck bone mineral density (BMD
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Molecular dynamics simulations are used to provide a detailed investigation of the hydrogen bond networks around the phosphatidylcholine (PC) head group in 1,2-dipropionyl-sn-glycero-3-phosphocholine in pure water, 10 mol.% and 30 mol.% dimethylsulfoxide (DMSO)-water solutions. Specifically, it is observed that DMSO replaces those water molecules that are within the first solvation shell of the ch
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Questions around school choice have attracted growing attention among educational scholars worldwide, and there is by now a burgeoning body of literature that links school choice to (i) the marketization and commercialization in education, (ii) new modes of governance in education, and (iii) individualized patterns of life-planning among families who see themselves increasingly exposed to global c
