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Oligonucleotides are short fragments of RNA or DNA that can act as active pharmaceutical ingredients (API) in medicines used to target a wide range of diseases, with further applications continuously emerging. Solid Phase Oligonucleotide Synthesis (SPOS) remains the dominant platform for oligonucleotide production. However, SPOS is characterized by high reagent consumption and a poor sustainabilit
This thesis explores arguments and styles of argumentation in favour of Scotland gaining independence and rejoining the European Union in the aftermath of the United Kingdom leaving the EU in 2020. Since a majority of Scots did not support Brexit, it has provided Scottish independence supporters with a unique opportunity to bolster their arguments in the political debate. The thesis is built on a
BACKGROUND: – Understanding circuit-level changes that either enhance or impair the brain’s capacity for recovery will inform the design of more specific, targeted interventions to enhance recovery from stroke. We previously reported that pharmacological blockade of mGlu5 (type-5 metabotropic glutamate) receptors improves recovery of sensorimotor function in rodent models of stroke, concomitant wi
This paper deals with the construction and orbital stabilization of periodic solutions for a particular underactuated mechanical system with 2 degrees of freedom, the Furuta pendulum. It is shown that if a desired periodic motion is described by constraints imposed on the total energy of the system and on the value of the directly actuated variable, then this periodic motion can be constructed and
Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs. Moreover, no treatments exist to prevent the development of epilepsy in those at risk, despite an increasing understanding of the underlying molecular and cellular pathways. One of the major factors that have impeded rap
A search for the lepton-flavor violating decays Bs0→φμ±τ is presented, using a sample of proton-proton collisions at center-of-mass energies of 7, 8, and 13 TeV, collected with the LHCb detector and corresponding to a total integrated luminosity of 9 fb-1. The τ leptons are selected using decays with three charged pions. No significant excess is observed, and an upper limit on the branching fracti
Obesity is a known risk factor for poor breast cancer outcomes, but its impact on endocrine therapy efficacy remains unclear. While the ATAC trial suggests reduced effectiveness of aromatase inhibitors (AIs) in women with obesity, the BIG 1–98 trial found no significant differences. Clinical and biological evidence indicates that obesity may impair AI efficacy by increasing aromatase activity and
This chapter explores the evolution and effectiveness of Sweden's climate policy mix for decarbonizing the transport sector—a major contributor to national greenhouse gas (GHG) emissions. Despite early leadership in climate policy, Sweden faces challenges in aligning policy implementation with ambitious goals, such as a 70 % reduction in transport emissions by 2030. The chapter shows that Sweden's
When experience is insufficient or not present at all, making decisions becomes difficult. Capability assessments are tools to inform decisions in all situations regarding risk management, but the use of them in Sweden is discussed. With experiments made in the microworld MikroRisk, conclusions can be made about the investment patterns induced by a capability assessment under the conditions of bot
An energy transition from centralised and fossil-fuelled installations towards decentralised and renewable energy has been advocated by governments, businesses and academia. In the EU it has become a regional strategy, and a desire of citizens, to enable communities to take an active role in the energy market in the hopes of transitioning to an increasingly local, renewable and participatory futur
The Internet of Things is coming. With it comes security challenges not present on common, more capable, devices such as desktop computers or servers. We argue that traditional channel security needs to be complemented with object security to cope with the constrained nature of small devices and Low Power Lossy Networks. The main reason for a partial transition to object security being heavy use o
This thesis mainly focuses on the protection strategies of microgrids for the Swedish power system in the medium voltage distribution system and specifically on the three-phase fault and earth faults protection strategies. For the analysis of both faults, different grid-connected, and islanding operations are simulated using DIgSILENT Power Factory. The simulation shows that using a distance prote
Background Companies producing premium products with high quality and long product life can experience challenges when trying to penetrate price-sensitive customer segments on emerging markets due to a high product price. One way to achieve growth in these segments is to introduce new innovative business models. From the theory of circular economy, a concept combining sustainable and economi
Background TitanX Engine Cooling is a global supplier of powertrain cooling solutions to commercial vehicles, both for OEMs and the independent aftermarket. The company with annual sales of over 1.6 billion SEK (US$ 192 million) has some 800 employees worldwide. TitanX is headquartered in Gothenburg, Sweden and has manufacturing sites in Sweden, USA, Brazil, China and Mexico. Its manufacturing fac
Background TitanX Engine Cooling is a global supplier of powertrain cooling solutions to commercial vehicles, both for OEMs and the independent aftermarket. The company with annual sales of over 1.6 billion SEK (US$ 192 million) has some 800 employees worldwide. TitanX is headquartered in Gothenburg, Sweden and has manufacturing sites in Sweden, USA, Brazil, China and Mexico. Its manufacturing fac
According to Swedish law, criminal offenders sentenced to time in prison are generally released after serving two thirds of their sentences. Henceforth, this concept is referred to as parole, which is when a criminal is provisionally released from prison, provided that certain conditions are met. The principal rule entails exceptions, and since May of 2021 the conditional release may be delayed du
