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Anti-neutrophil cytoplasmic antibodies predate symptom onset of ANCA-associated vasculitis. A case-control study

Objectives: Anti-neutrophil cytoplasmic autoantibodies [ANCA) are important for diagnosis of ANCA-associated vasculitides (AAV). The timing of antibody development is not well established. To investigate the development of proteinase 3 (PR3)- and myeloperoxidase (MPO)-ANCA, blood samples collected before onset of symptoms of AAV were analysed. Methods: To identify AAV patients with blood samples p

Soluble CD40 receptor is a biomarker of the burden of carotid artery atherosclerosis in subjects at high cardiovascular risk

BACKGROUND AND AIMS: The severity of the atherosclerotic burden is hardly quantifiable in subjects at high cardiovascular (CV) risk under intensive pharmacological therapy. Several molecules have been proposed as circulating biomarkers of atherosclerosis, but none has emerged as clinically meaningful.METHODS: Circulating proteins involved in inflammation, plaque remodeling, smooth muscle cell migr

The power of genetic diversity in genome-wide association studies of lipids

Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels2, heart disease remains the leading cause of death worldwide3. Genome-wideassociation studies (GWAS) of bloo

Time between anterior cruciate ligament injury and reconstruction and cartilage metabolism six-months following reconstruction

Background: To determine the association between time from injury to ACL reconstruction (TimeInjury-ACLR) and biochemical markers of cartilage metabolism and inflammation six months following ACL reconstruction (ACLR). Methods: Individuals with a unilateral ACL injury were enrolled at initial presentation in the orthopedic clinic; blood was collected six months following ACLR. Enzyme-linked immuno

Sevoflurane provides better haemodynamic stability than propofol during right ventricular ischaemia-reperfusion

OBJECTIVES: To assess whether sevoflurane provides better haemodynamic stability than propofol in acute right ventricular (RV) ischaemia-reperfusion. METHODS: Open-chest pigs (mean ± standard deviation, 68.8 ± 4.2 kg) anaesthetized with sevoflurane (n = 6) or propofol (n = 6) underwent 60 min of RV free wall ischaemia and 150 min of reperfusion. Haemodynamic parameters and blood flow in the 3 majo

Everolimus Initiation With Early Calcineurin Inhibitor Withdrawal in De Novo Heart Transplant Recipients : Long-term Follow-up From the Randomized SCHEDULE Study

BACKGROUND: A calcineurin inhibitor (CNI)-free immunosuppressive regimen has been demonstrated to improve renal function early after heart transplantation, but long-term outcome of such a strategy has not been well described. METHODS: In the randomized SCHEDULE trial, de novo heart transplant recipients received (1) everolimus with reduced-exposure CNI (cyclosporine) followed by CNI withdrawal at

Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes : A Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies

Published meta-analyses indicate significant but inconsistent incident type-2 diabetes(T2D)-dietary glycemic index (GI) and glycemic load (GL) risk ratios or risk relations (RR). It is nowover a decade ago that a published meta-analysis used a predefined standard to identify validstudies. Considering valid studies only, and using random effects dose-response meta-analysis(DRM) while withdrawing sp

Genome-wide association meta-analysis of functional outcome after ischemic stroke

OBJECTIVE: To discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study. METHODS: The study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, the United States, and Australia included in the GISCOME (Genetics of Ischaemic Stroke Functional Outcome) network. The primary outcome was modified Rankin Scale score after 60 to

Sedimentation of Nodularia spumigena and distribution of nodularin in the food web during transport of a cyanobacterial bloom from the Baltic Sea to the Kattegat

Nodularia spumigena is a toxic cyanobacteria that blooms in the Baltic Sea every year. In the brackish water of the Baltic Sea, its toxin, nodularin, mainly affects the biota in the surface water due to the natural buoyancy of this species. However, the fate of the toxin is unknown, once the cyanobacteria bloom enters the more saline waters of the Kattegat. In order to investigate this knowledge g

Renal function after out-of-hospital cardiac arrest; The influence of temperature management and coronary angiography, a post hoc study of the target temperature management trial

Background: To elucidate the incidence of acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) and to examine the impact of target temperature management (TTM) and early coronary angiography on renal function. Methods: Post hoc analysis of the TTM trial, a multinational randomised controlled trial comparing target temperature of 33 °C versus 36 °C in patients with return of sponta

Inventering av risken för förgiftning av bin med växtskyddsmedel av typen neonikotinoider under svenska förhållanden : Slutrapport 2015

EU har sedan 2013 begränsat användningen av tre neonikotinoider i grödor som är attraktiva för bin. En stor del av den kunskap vi har idag om hur bin påverkas av neonikotinoider kommer från laboratoriestudier av framförallt honungsbin som har matats med växtskyddsmedel. I ett forskningsprojekt har forskare från Lunds universitet och SLU i samarbete med Jordbruksverket undersökt hur ett växtskyddsm

Intraductal papillary mucinous carcinoma versus pancreatic ductal adenocarcinoma : A systematic review and meta-analysis

Background: Previous studies have indicated that there may be a difference in tumor biology between intraductal papillary mucinous carcinoma (IPMC) and pancreatic ductal adenocarcinoma (PDAC). However, the data are still controversial. The aim of this systematic review and meta-analysis was to summarize and compare the outcome of IPMC and PDAC after surgical resection. Methods: Studies comparing I

Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea : A systematic review with meta-analysis

BACKGROUND Diarrhea is a major infectious cause of childhood morbidity and mortality worldwide. In clinical trials, Lactobacillus rhamnosus GG ATCC 53013 (LGG) has been used to treat diarrhea. However, recent randomized controlled trials (RCTs) found no evidence of a beneficial effect of LGG treatment. AIM To evaluate the efficacy of LGG in treating acute diarrhea in children. METHODS The EMBASE,

Islet adaptation in GIP receptor knockout mice

Glucose-dependent insulinotropic polypeptide (GIP) receptor knockout (KO) mice are tools for studying GIP physiology. Previous results have demonstrated that these mice have impaired insulin response to oral glucose. In this study, we examined the insulin response to intravenous glucose by measuring glucose, insulin and C-peptide after intravenous glucose (0.35 g/kg) in 5-h fasted female GIP recep

In vivo evidence of differential frontal cortex metabolic abnormalities in progressive and relapsing-remitting multiple sclerosis

The pathophysiology of progressive multiple sclerosis remains elusive, significantly limiting available disease-modifying therapies. Proton MRS (1 H-MRS) enables in vivo measurement of small molecules implicated in multiple sclerosis, but its application to key metabolites glutamate, γ-aminobutyric acid (GABA), and glutathione has been sparse. We employed, at 7 T, a previously validated 1 H-MRS pr

Health care workers' self-perceived infection risk and COVID-19 vaccine uptake : A mixed methods study

Vaccination is the most cost-effective way of preventing Coronavirus Disease 2019 (COVID-19) although there was a considerable delay in its institution in Tanzania. This study assessed health care workers' (HCWs) self-perceived infection risk and uptake of COVID-19 vaccines. A concurrent embedded, mixed methods design was utilized to collect data among HCWs in seven Tanzanian regions. Quantitative

Rad-och-anvisningar Reviderad 241120

DISPUTATIONSANVISNINGAR Råd och anvisningar inför din disputation Du har bokat tid för disputation (https://disputationsbokning.web.med.lu.se/) och vi översänder därför sådan information som vi tror du kan ha nytta av. Förberedelserna innebär en hel del administration, ofta med knappa tidsmarginaler. Ansvaret för att proceduren genomförs på ett korrekt sätt vilar huvudsakligen på doktoranden själv

https://www.intramed.lu.se/sites/intramed.lu.se/files/2024-11/rad-och-anvisningar%20reviderad%20241120.pdf - 2026-05-23

Fargvariation-rev-juni2020

Exempel på färgvariation i grafiskt material från Lunds universitet Rubrik UNDERTEXT Färgvariation Uppslag ur presentationsbroschyr. Detta blädderdokument innehåller ett urval exempel med bra färgvariation. Du hittar fler exempel i övriga blädderdokument. A WORLD-CLASS UNIVERSITY To understand, explain and improve Lund University was founded in 1666 and, ever since, has been a centre of culture an

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/fargvariation-rev-juni2020.pdf - 2026-05-23

Geol01 kursutvardering 2017

Kursutvärdering GEOL01, Kandidatarbete,VT 2017 Antal respondenter: 27 Antal svar: 17 Svarsfrekvens: 62,96 % Markera det alternativ som bäst stämmer överens med vad du tycker (1= håller inte alls med --- 5=håller fullständigt med) Jag är nöjd med den här kursen. Jag är nöjd med den här kursen. Antal svar 1 0 (0,0%) 2 2 (11,8%) 3 7 (41,2%) 4 6 (35,3%) 5 2 (11,8%) Summa 17 (100,0%) Medelvärde Standar

https://www.geologi.lu.se/sites/geologi.lu.se/files/geol01_kursutvardering_2017.pdf - 2026-05-23