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Mitigating the impact of study-start delays in clinical trials for rare disorders : insights and lessons from a PKAN trial

Background: Rare disease clinical trials are notorious for complexities that frequently result in study-start delays. However, there is limited knowledge about how participants and researchers perceive these delays and what factors shape their experiences. A clinical trial in the rare, progressive disorder Pantothenate Kinase-Associated Neurodegeneration—the PKAN trial—encountered an unexpected de

Linking Trade with Labour Rights: the ILO Garnment Sector Working Conditions Improvement Project in Cambodia

As of January 1, 2005, it will no longer be allowed under international trade rules for one country to impose import quotas on textiles and garments on another country. It is widely expected that the expiration of the 1974 Multifiber Arrangement will lead to a drastic re-shuffle of garment production and trade patterns. Where a number of countries were previously guaranteed a share of the European

Mammalian Molecular Systematics with Emphasis on the Insectivore Order Lipotyphla

Insectivore classification has been one of the most controversial problems in mammalian systematics. Evolutionary relationships among the six extant families, Talpidae (moles), Soricidae (shrews), Erinaceidae (hedgehogs), Tenrecidae (tenrecs), Chryosochloridae (golden moles), and Solenodontidae (solenodons), have remained uncertain based on morphological data. Animals classified within the order L

Meta Isæus-Berlin på Skissernas museum / Meta Isæus-Berlin at Skissernas museum

Meta Isæus-Berlin at Skissernas museum Many visitors will surely remember Ett vattenhem (A Water Home), five strikingly ambiguous furnished rooms set out on a low podium in the middle of the main walkway at the Bo01 Housing Fair in Malmö in 2001. The Hall and the Bathroom, at opposite ends of the long and narrow, windowless pavilion, were open to the world and visible from outside. The Bathroom

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The World Human Rights Cities Forum Paper Series II WHRCF 2021 Human Rights Cities’ Responses to the COVID-19 Pandemic: Localization of Human Rights Based Solutions for the Development of Inclusive Societies Paper Series III WHRCF 2022 Human Rights, Environment and Climate Change: Developing Human Rights Based Solutions for Sustainable, Inclusive and Climate-resilient Cities 2 Published by The Rao

https://rwi.lu.se/wp-content/uploads/2023/12/The-WHRCF-Joint-Paper-Series_20212022.pdf - 2026-05-31

Theory and numerics of phase field models for solidification of binary alloys

The phase field method emerged as a tool to solve free boundary problems with a sharp interface. In previous methods, this involved the computationally inefficient and complicated tracking of a moving interface. The phase field method overcomes this limitation by introducing an auxiliary variable called the order parameter which varies continuously over the whole domain and takes on finite values

Ephemeral Selves: A semiotic cultural analysis of a Swedish bicycle helmet campaign

Under 2014 så delade Lunds kommun ut 830 gratis cykelhjälmar. Sådana styrande kampanjer är vanliga i Sverige, ändå har ingen kampanj någonsin blivit utvärderad. Syftet med denna uppsats är tvådelad. Först, att utvärdera hur många av de 830 cyklisterna som faktiskt bär hjälmen som de blev tilldelade. Sedan, att nå insikt om varför vissa cyklister väljer att bära hjälmen och varför andra väljer att In 2014, Lund municipality in Sweden handed out 830 bicycle helmets for free. Such governance campaigns are commonplace in Sweden, yet no campaign has ever been evaluated. There are two research aims to this thesis. First, to evaluate how many of the 830 cyclists actually wear the bicycle helmets that they received. Second, to gain insight into why some cyclists choose to wear the helmet that they

Renskötsel & vindbruk – Om renskötselrättens räckvidd mot det starka allmänintresset för vindkraft

Uppsatsen behandlar konflikten mellan två inte sällan kolliderande intressen, vindkraft och rennäring. I ljuset av folkrättsliga instrument till skydd för urfolk, ska samernas rätt till mark och vatten skyddas. För samer är denna rätt en förutsättning för renskötselns bedrivande, som det samiska kulturarvet i stora delar bygger på. Rennäringen förutsätter stora markområden där renar fritt kan flytThis essay discusses the conflict between wind power and reindeer husbandry, two interests which at times collide. In light of international law and its instruments for the protection of indigenous peoples, the Samis’ rights to land and water shall be protected. The right to land is a prerequisite for the Samis to pursue their reindeer herding, which lays the foundation for the cultural heritage o

Medellösa processubjekt i frontlinjen - En civilprocessuell studie av ersättningsgilla rättegångskostnader i ljuset av tredjepartsfinansiering

En huvudprincip i den svenska rättsordningen är att den förlorande parten i ett tvistemål ska ersätta den vinnande parten för dennes rättegångskostnader. Ersättningen till den vinnande parten ska i enlighet med 18 kap. 8 § rättegångsbalken (1942:740), fullt motsvara kostnaderna för processföringen, såvitt kostnaderna skäligen varit påkallade för tillvaratagande av partens rätt. Inom ramen för partAn essential rule in Swedish law is that the losing party in a litigation shall reimburse all costs incurred by the winning party. Section 8 in Chapter 18 of the Swedish Code of Judicial Proceedings (1942:740) concludes that “compensation for litigation costs shall fully cover the costs of preparation for trial […] to the extent that the costs were reasonably incurred to safeguard the party's

Barn som begår brott - En utvärdering av 31 § LUL

Barn som är under 15 år kan inte straffas i svensk rätt enligt 1 kap. 6 § brottsbalken (BrB) och därmed kan de inte heller bli föremål för rättsväsendets åtgärder p.g.a. brott. När samhällsåtgärder därmed måste tas, ligger ansvaret på socialtjänsten. Begår ett barn ett brott kan det ändå utredas av polis och åklagare genom stöd av lagen om unga lagöverträdare (LUL), en s.k. 31 § LUL-utredning. SChildren under the age of 15 can commit crimes but they cannot be punished under Swedish law in accordance with Chapter 1, Section 6 of the Criminal Code and therefore they cannot be subject to a preliminary criminal investigation by a Prosecutor or the Police. Instead, when children have committed a crime other societal measures can be taken. The responsibility for the care for these children lie

Extraction of Cellulose and Nanocellulose from the Green Seaweed Ulva sp.1 for Characterisation and Investigation of Processing Effects

Development of valuable products from downstream process residual biomasses and profound reduction of waste are two key components for developing a more sustainable process industry. The importance of bio-renewable feedstocks and bio-based processing techniques are also crucial in the transformation to a more sustainable and green society. Therefore focus is directed on full exploitation of seawee

Rättstryggheten och rättssäkerheten i rättspraxis om oaktsam våldtäkt - Uppfyller domstolarna syftena med 2018 års samtyckeslagstiftning?

I denna uppsats behandlar jag brottet oaktsam våldtäkt i den svenska brottsbalkens (BrB) 6 kap. 1 a §. Bestämmelsen infördes i samband med 2018 års lagförändringar i sexualbrottslagstiftningen, i folkmun samtyckeslagen. Straffansvar kräver bla. grov oaktsamhet i förhållande till rekvisitet den andra personens icke-frivilliga deltagande, det är häri uppsatsens fokus uteslutande ligger. Jag beskriveIn this essay, I present the offense negligent rape, regulated in chapter 6 paragraph 1 a in the Swedish Penal Code. The provision was established in connection with the legislative change of Sweden’s sexual offences legislation in 2018, commonly called the consent regulation. Criminal liability requires, among other, gross negligence in relation to the necessary prerequisite the other person’s no

Han ser rött, men ser han? - En kritisk analys av bevisning av uppsåt med särskilt fokus på självförvållat rus

För närmare åtta år sedan, 2011, ändrade Högsta domstolen (HD) sin tidigare praxis avseende tolkningen av 1 kap. 2 § andra stycket brottsbalken (BrB) – alltså det lagrum som reglerar uppsåt vid självförvållat rus. Den nya tolkningen innebar att uppsåt i dessa fall skulle behandlas enligt vanliga regler om uppsåt. Det är således inte längre fråga om att fingera uppsåt, inte ens i någon mån. SuzanneNearly eight years ago, in 2011, the supreme court of Sweden changed its previously established practice regarding the interpretation of Chapter 1, art. 2, 2nd paragraph of the Penal Code1 where intent and self-induced intoxication are addressed. A consequence of the new interpretation was that criminal intent in such cases of intoxication should instead be tried as intent in general and thus ther

Sustainability-Linked Bonds: An investigation of premiums associated with sustainability-linked bonds

Sustainable finance has become of great importance over the past years, especially due to global climate development, resulting in increased awareness among public and private sectors, and hence, more conscientious investors. In a market familiar with green bonds, Sustainability-Linked Bonds (SLBs) emerged as a new financial instrument posing a lesser greenwashing risk and, therefore, greater pote

Transgenerational effects of maternal infection in great reed warblers (Acrocephalus arundinaceus)

Kronisk malaria i en flyttfågel: Sjuka mammor har favoritungar. Precis som människor kan djur bli sjuka. Dessa sjukdomar spelar en stor roll i ekosystem, bland annat för att de kan ge negativ påverkan på populationsstorlekar via ökad dödlighet och minskad fortplantningsframgång (fitness) bland infekterade individer. En sådan sjukdom är fågelmalaria. Trastsångaren (Acrocephalus arundinaceus) är en

NTCP modelling of lung toxicity after SBRT comparing the universal survival curve and the linear quadratic model for fractionation correction

Background. In SBRT of lung tumours no established relationship between dose-volume parameters and the incidence of lung toxicity is found. The aim of this study is to compare the LQ model and the universal survival curve (USC) to calculate biologically equivalent doses in SBRT to see if this will improve knowledge on this relationship. Material and methods. Toxicity data on radiation pneumonitis

Gruppundantagsförordning nr 772/2004 för avtal om tekniköverföring

Konkurrensrätt och immaterialrätt har länge betraktats vara rättsområden som skyddar motstående intressen. En av de regleringar som finns för att underlätta förhållandet mellan de två rättsområdena är kommissionens förordning nr 772/2004 för grupper av avtal om tekniköverföring. Genom denna förordning önskar kommissionen garantera en effektiv konkurrens på marknaden samt erbjuda företag som ingår Competition Law and Intellectual Property Law are sometimes considered as areas of law which protect conflicting interests. One of the regulations striving to facilitate the relationship between these two areas is Regulation 772/2004, on the application of article 101.1 TFEU to categories of technology transfer agreements. The objectives of this Regulation are to ensure effective competition and t

Frequency Recognition Algorithm for Multiple Exposures : Snapshot imaging using coded light

The central challenge tackled in this thesis is the development of an optical imaging approach capable of multidimensional image capture of dynamic samples. Many conventional optical imaging approaches, which can obtain dimensional information such as spectral, polarisation, or volumetric, to name a few, about samples either employ sequential image capture or parallelised detector arrangements. Du

Health effects related to exposure of static magnetic fields and acoustic noise—comparison between MR and CT radiographers

Objectives: We explored the prevalence of health complaints subjectively associated with static magnetic field (SMF) and acoustic noise exposure among MR radiographers in Sweden, using CT radiographers as a control group. Additionally, we explored radiographers’ use of strategies to mitigate adverse health effects. Methods: A cross-sectional survey was sent to all hospitals with MR units in Sweden