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Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo.

Antibody-mediated blockade of CTLA4 has been shown to be effective in treating a select group of patients with late-stage melanoma. The precise mechanism underlying the clinical activity of CTLA4 immunotherapy is poorly understood, although recent experimental findings indicate that antibody-mediated depletion of regulatory T cells (Tregs) in the tumor microenvironment plays a key role in efficaci

Eosinophils in anti-neutrophil cytoplasmic antibody associated vasculitis

Background: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) are characterized by autoimmune small vessel inflammation. Eosinophils are multifunctional cells with both pro-inflammatory and immunoregulatory properties. Tissue activated eosinophils secrete cyto- and chemokines and form extracellular traps (EETs), they release free granules and produce reactive oxygen species. The

Circulating Human Basophils and Dendritic Cell Subsets. Aspects of antigen recognition and presentation in type I allergic immune responses

Popular Abstract in Swedish En tredjedel av befolkningen i världens industrialiserade länder lider av allergi, t.ex. allergisk rinit (hösnuva). Trots detta vet man relativt lite om de cellulära och molekylära mekanismer som ligger till grund för det immunologiska svaret vid allergi. Genom att studera dessa mekanismer kan man hitta sätt att angripa dem, vilket förhoppningsvis kan leda till bättre lAllergic diseases currently affect a third of the population in the industrialized parts of the world. Despite this, the cellular and molecular mechanisms involved in the induction and activation of allergic diseases are not fully clarified. Dendritic cells (DCs) link the innate and adaptive immunity and play vital roles in protective immunity against pathogens, as well as in inducing tolerance t

Studies of bacterial surface proteins interacting with the immune system

Popular Abstract in Swedish En av de viktigaste substanserna i vår kropp är proteiner, också kallade äggviteämnen. Proteiner har en mängd olika uppgifter i kroppen, de finns i våra celler där de har olika uppgifter såsom att fungera som enzymer, transportörer, signalsubstanser, eller som skyddsfaktorer. Proteiner ingår också som viktiga beståndsdelar i vävnaderna mellan cellerna och finns dessutomPathogenic bacteria express a wide array of surface proteins that interact with the environment. Many of these proteins are believed to be important for the virulence. This thesis deals with the binding of immunoglobulins (Ig) and complement regulating proteins to certain bacterial surface proteins. Protein L from Peptostreptococcus magnus binds to Igk-light chains while protein A from Staphylococ

IL1RAP Blockade with a Monoclonal Antibody Reduces Cardiac Inflammation and Preserves Heart Function in Viral and Autoimmune Myocarditis

BACKGROUND: Currently, there are no therapies targeting specific pathogenic pathways in myocarditis. IL (interleukin)-1 blockade has shown promise in preclinical studies and case reports. We hypothesized that blockade of IL1RAP (IL-1 receptor accessory protein), a shared subunit of the IL-1, IL-33, and IL-36 receptors, could be more efficient than IL-1 blockade alone. METHODS: We induced coxsackie

Oxygen and its impact on nitrification rates in aquatic sediments

Eutrofiering det oönskade fenomenet av hög näringstillförsel i ett akvatiskt system, är för det mesta ett resultat av mänsklig påverkan: industriellt och urbant avloppsvatten, avrinning av gödningsmedel från odlad mark, och förbränning av fossila bränslen. Studien av de främsta faktorerna som bidrar till eutrofiering (t. ex. variationer i kvävets kretslopp), är viktigt för förståelsen av dess negaEutrophication, the undesired phenomenon of high nutrient loads in an aquatic system, is mostly caused by human impact: industrial and urban waste water discharge, run-off of fertilizers from agricultural use, and combustion of fuels. The study of eutrophications' main participants such as the nitrogen cycle, are necessary to prevent it. Environmental parameters have an impact onto the effecti

Retreat Program

October 24-25, Medicon Village MultiPark Retreat 2024 Program DAY 1 - THURSDAY, OCTOBER 24 1 9:30 - 10:30 10:30 - 11:00 11:00 - 12:15 12:15 - 13:30 Session title: Neurodegenerative Disease Research Through Time to Today Session title: Tandem Talks - Synergizing Popular Science and Traditional Data Presentations Fika and final poster setup Lunch @ Restaurant Inspira Continued on the next page On Pa

https://www.multipark.lu.se/sites/multipark.lu.se/files/2024-10/Retreat%20Program.pdf - 2026-05-03

1blankett etablering av doktorand i ladok

Etablering av doktorand i Ladok / Admission of post graduate student in LADOK Uppgifter om antagen doktorand / Personal data of admitted post graduate student Efternamn, tilltalsnamn / Last name, first name Personnummer/Personal identity number Födelsedatum/Date of Birth Bostadsadress/ Home address Kön/Gender Kvinna/Female Man/Male Postnummer, ortnamn, land/Post code, city, country Telefonnummer/P

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/1blankett_etablering_av_doktorand_i_ladok.pdf - 2026-05-03

Geol01-installation av endnote ac

Microsoft Word - GEOL01Installation av EndNote-2.docx Installation av EndNote För att ladda ner EndNote, gå till Studentportalen (via Lunds universitets hemsida, välj Student, sedan Studentportalen, eller http://www.student.lu.se/uPortal/render.userLayoutRootNode.uP) Logga in med ditt Stil-id. Välj Mina tjänster, sedan Hämta programvaror. Gör du detta när du befinner dig utanför Lunds universitets

https://www.geologi.lu.se/sites/geologi.lu.se/files/geol01-installation_av_endnote_ac.pdf - 2026-05-03

Forteckning over codices 0

Förteckning över De la Gardieska arkivet: Paleotyper, Cod. coll. och Cod. Per Stobaeus 2010 UNIVERSITETSBIBLIOTEKET, LUNDS UNIVERSITET 1 Inledning I De la Gardieska arkivet (även kallat De la Gardieska samlingen) i Universitetsbiblioteket i Lund finns tre serier med bundna volymer med beteckningarna Paleot., Cod. coll. och Cod. Volymerna har skiftande proveniens men alla har ingått i Jacob De la G

https://www.ub.lu.se/en/sites/ub.lu.se.en/files/forteckning_over_codices_0.pdf - 2026-05-03

Forteckning over codices

Förteckning över De la Gardieska arkivet: Paleotyper, Cod. coll. och Cod. Per Stobaeus 2010 UNIVERSITETSBIBLIOTEKET, LUNDS UNIVERSITET 1 Inledning I De la Gardieska arkivet (även kallat De la Gardieska samlingen) i Universitetsbiblioteket i Lund finns tre serier med bundna volymer. Volymerna har skiftande proveniens men alla har ingått i Jacob De la Gardies (1768–1842) samling på Löberöd innan de

https://www.ub.lu.se/en/sites/ub.lu.se.en/files/forteckning_over_codices.pdf - 2026-05-03

Workshop on publishing

2 april 2025 15:00 till 17:00 | Workshop Welcome to a workshop arranged by Lund University Diabetes Centre and the strategic research area EXODIAB dedicated to discussing publication of scientific projects. This workshop will be led by Jennifer Sargent, who brings a wealth of experience as the former Deputy Editor at Nature Medicine and Senior Editor at Lancet. Jennifer is the founder of BabelFisk

https://www.medicin.lu.se/evenemang/workshop-publishing - 2026-05-04

No title

Lärares kompetenser och medvetna val - i en digitaliserad skola Karin Ollinen Kommunlicentiand - CSIS Helsingborgs stad, IT-pedagogiska frågor Handledare Pernilla Nillson (Högskolan i Halmstad) Roger Nilssin (Campus Helsingborg) Syfte Skapa en större medvetenhet kring lärares olika professionella kompetenser (ramverket TPACK), hur de samverkar därmed drar nytta av teknikens möjligheter. Brainstorm

https://www.uvet.lu.se/fileadmin/user_upload/uvet/Licentiandutbildningen/Dokument/Karin_Ollonen__forskning.pdf - 2026-05-02

Choosing your major

Choosing Your Major! As a BIDS student you have an opportunity to specialize within your degree in one of the following four disciplines: • Economic History • Human Geography • Political Science • Sociology You will make your choice during year 1 in the spring application period which occurs between mid March and mid April. Since courses may vary from one year to another, we will schedule a meetin

https://www.keg.lu.se/sites/keg.lu.se/files/choosing_your_major.pdf - 2026-05-03