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Cfewp13

CFE wp- Nr 13 1Russia in a Western Mirror Russia in a Western mirror A presentation of Denis Diderot, Mme de Staël and André Gide Anna Rédei Cabak 2 CFE Working paper series no. 13 CENTRE FOR EUROPEAN STUDIES AT LUND UNIVERSITY: Box 52 Phone: +46 (0)46-222 88 99 SE-221 00 LUND Fax: +46 (0)46-222 40 06 Sweden Email: cfe@cfe.lu.se CFE Working paper series is published by Centre for European Studies

https://www.cfe.lu.se/en/sites/cfe.lu.se.en/files/2020-12/cfewp13.pdf - 2026-05-16

ICOS-ligand triggering impairs osteoclast differentiation and function in vitro and in vivo

Osteoblasts, osteocytes, and osteoclasts (OCs) are involved in the bone production and resorption, which are crucial in bone homeostasis. OC hyperactivation plays a role in the exaggerated bone resorption of diseases such as osteoporosis, rheumatoid arthritis, and osteolytic tumor metastases. This work stems from the finding that OCs can express B7h (ICOS-Ligand), which is the ligand of the ICOS T