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GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65

GAD65 autoantibodies (GAD65Ab) are highly prevalent in type 1 diabetes, but their functional role in the pathogenesis of the disease and their relationship to T-cell reactivity to GAD65 is still unclear. We tested the hypothesis that GAD65Ab modulate presentation of GAD65 to T-cells. T-cell hybridoma T33.1, which recognizes the GAD65 274-286 epitope in the context of HLA-DRB1*0401, was incubated w

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The aim of present study was to arrange an experimental rabbit model for IgA-nephropathy. To this purpose, an approach was attempted which was previously successfully applied in rabbits, aiming for induction of post-streptococcal glomerulonephritis (PSGN). To induce the nephropathy, we used two Streptococcus pyogenes strains of M4 and M60 serotypes which showed differential IgA-binding capacity me

Molecular mapping of epitopes for interaction of HIV-1 as well as natural ligands with the chemokine receptors, CCR5 and CXCR4.

OBJECTIVE: Mapping coreceptor epitopes used by the prototypic R5 and X4 strains, HIV-1BaL and HIV-1IIIB, in comparison with epitopes involved in the activation and signaling induced by the natural ligands, RANTES and SDF-1beta. DESIGN: Receptor hybrids between CCR5 and CXCR4 were constructed. METHODS: Using single-overlap and extension PCR, increasing portions of CCR5 were replaced with correspond

Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in Neisseria gonorrhoeae

Neisseria gonorrhoeae is the etiological agent of gonorrhea, the second most common bacterial sexually transmitted infection worldwide. Reproductive sequelae of gonorrhea include infertility, ectopic pregnancy and chronic pelvic pain. Most antibiotics currently in clinical use have been rendered ineffective due to the rapid spread of antimicrobial resistance among gonococci. The developmental pipe

Production and Functional Characterization of Der p 1-Specific Human Recombinant IgE

Ny forskning bidrar till ökad förståelse av allergiska reaktioner Allergi har ökat dramatiskt under de senaste åren. Det är därför högst väsentligt att få ökad kunskap om hur beståndsdelarna i immunförsvaret hos allergiska personer samspelar. Förekomsten av allergi har kommit att öka dramatiskt under de senaste åren och har blivit ett betydande problem för folkhälsan. Allergi drabbar en så stor dThe prevalence of allergic disease is continuing to increase worldwide, and it has even become a major concern in public health. Allergic reactions are developed to otherwise harmless substances and may be both life-threatening as well as discomforting for patients in their daily life. Therefore, a more detailed knowledge about how antibodies interact with allergens and effector cells in allergic

Samtida internationell scenkonst - en orientering

Fristående kurs på distans, 7.5 högskolepoäng Vill du möta scenkonstnärer och teatrar i olika länder, inspireras av samtida internationell scenkonst, samt bilda dig en uppfattning om estetiska strömningar och skapandets varierande förutsättningar? Kom då med på denna onlineorientering och berika din förståelse av världen genom scenkonst. Under kursen görs flera live-filmade besök på scenkonst-orga

https://www.thm.lu.se/samtida-internationell-scenkonst-en-orientering - 2026-05-27

Hungry Eyes

Friday, at 19:00 – Performance "Immanuel, Immanuel!" by Hungry Eyes Hungry Eyes is a Danish–Swedish performance collective founded by Theatre Academy alumni Dina Viksten Abrahamson, Ida Østman, Mie Kristensen and Olivia Klang. At IAC, they present their second work Immanuel, Immanuel! – a conceptual exploration of the choir as form and method. A choir without choral singing, an essayistic, hopeful

https://www.iac.lu.se/hungry-eyes - 2026-05-27

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Michelle et Monique sont deux filles qui aiment de voyager. Elles ont été au Danemark, en Algérie, aux Étatés-Unis, en Angleterre et en Espagne. Mais cette temps elles voulent de visiter une payé éxotique. Michelle et Monique ´ont décidé de voyager en Italie. Michelle: En Italie il fait chaud et on peut bagner et bronzer. Monique: Précisément! Et la norritûre et super. Michelle: J'aime la langue b

https://projekt.ht.lu.se/fileadmin/user_upload/project/cefle/textes/le_sous-corpus_transversal/stade_c/Chlo%C3%A9.txt - 2026-05-28

Industrial Alloys Studied by Surface Sensitive Techniques

Populärvetenskaplig sammanfattning/Populärwissenschaftliche Zusammenfassung (först på svenska/Schwedisch och därefter på tyska/Deutsch)Nästan alla metalliska material som används idag är legeringar. Detta beror på att legeringen har förbättrade fysiska egenskaper som hållfasthet, slitstyrka och korrosionsbeständighet och dessutom bättre prestanda vid höga temperaturer jämfört med de enskilda rena This thesis reports on surface studies of industrial materials whose importance for society manifests in the vast range of applications. In industrial materials alloying is performed in order to improve the parent material's physical and mechanical properties such as strength, corrosion and wear resistance, as well as high temperature performance in comparison to the pure metal.Even though metals

Information om andring av betyg - 2015-12-02

1 Ändring av betygsbeslut Syftet med informationen är att tydliggöra vad som gäller vid ändring av betygsbeslut. Beslut om betyg går inte att överklaga. 1 Däremot finns bestämmelser om rättelse och omprövning av beslut i förvaltningslagen och högskoleförordningen. 2 Innan ett betygsbeslut har expedierats i någon form, t.ex. registrerats i Ladok, besked om betyg skickats hem till studenten, lagts u

https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/information_om_andring_av_betyg_-_2015-12-02.pdf - 2026-05-29

SBSS – Safe Battery Summer School

The Combustion Institute and IAFSS Summer School on Battery Safety will bring together doctoral students, post-doctoral fellows and a limited number of Master students as well as distinguished lecturers from around the world. The summer school will be held near Lund University in Sweden between August 24th and 28th, 2026. The summer school will cover topics from an introduction to cell design, fir

https://www.buildtech.lth.se/sbss-safe-battery-summer-school - 2026-05-27

Masculinity and privilege - Analyzing corruption in Vietnam

The purpose of this thesis is to discuss and analyze how constructions of masculinity and femininity are intertwined with land-related corruption in Vietnam. Drawing on masculinity theory and Nancy Fraser’s conceptualization of institutionalized injustice and participatory parity the thesis examines the relation between kinship systems and corruption and whether corruption leads to increased use o

Valuation and Optimization of Credit Risk using a Portfolio Model

In this paper I study a model for credit risk in a portfolio of sovereign bonds, based on (van der Hoorn, 2009). The model is based on historical credit rating changes and the joint distribution of the losses for dier- ent bonds is modeled with an assumption of an underlying multivariate Gaussian variable. Dierent risk measures for the portfolio are calculated using Monte Carlo simulations and the

2015-05-25

Delegated decisions, Enclosure 2 Travel Grants   Applicant Amount (SEK) Kind of activity Approved by Group affiliation Date of approval Tomas  Olsson   7  000   The  12th  International   Conference  on  Alzheimer's   and  Parkinson's  Diseases  and   related  neurological  disorders   (AD/PD),  Nice,  France,  March   17th-­‐22nd,  2015   Roger   Olsson   Gunnar   Gouras   2015-­‐03-­‐ 04   Itzia

https://www.multipark.lu.se/sites/multipark.lu.se/files/2015-05-25.pdf - 2026-05-29

The effect of relative humidity on eddy covariance latent heat flux measurements and its implication for partitioning into transpiration and evaporation

While the eddy covariance (EC) technique is a well-established method for measuring water fluxes (i.e., evaporation or 'evapotranspiration’, ET), the measurement is susceptible to many uncertainties. One such issue is the potential underestimation of ET when relative humidity (RH) is high (>70%), due to low-pass filtering with some EC systems. Yet, this underestimation for different types of EC sy

IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G.

Recent work from several laboratories has demonstrated that proteolytic mechanisms significantly contribute to the molecular interplay between Streptococcus pyogenes, an important human pathogen, and its host. Here we describe the identification, purification and characterization of a novel extracellular cysteine proteinase produced by S.pyogenes. This enzyme, designated IdeS for Immunoglobulin G-