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Accumulation of Intraneuronal beta-Amyloid 42 Peptides Is Associated with Early Changes in Microtubule-Associated Protein 2 in Neurites and Synapses

Pathologic aggregation of beta-amyloid (A beta) peptide and the axonal microtubule-associated protein tau protein are hallmarks of Alzheimer's disease (AD). Evidence supports that A beta peptide accumulation precedes microtubule-related pathology, although the link between A beta and tau remains unclear. We previously provided evidence for early co-localization of A beta 42 peptides and hyperphosp

Comprehensive bioinformatic analysis of the specificity of human immunodeficiency virus type 1 protease

Rapidly developing viral resistance to licensed human immunodeficiency virus type 1 (HIV-1) protease inhibitors is an increasing problem in the treatment of HIV-infected individuals and AIDS patients. A rational design of more effective protease inhibitors and discovery of potential biological substrates for the HIV-1 protease require accurate models for protease cleavage specificity. In this stud

Condensation and evaporation heat transfer characteristics in horizontal smooth, herringbone and enhanced surface EHT tubes

An experimental investigation was performed to evaluate convective condensation and evaporation of R22, R32 and R410A inside a smooth tube (inner diameter 11.43 mm), a herringbone tube (fin root diameter 11.43 mm) and a newly developed enhanced surface EHT tube (inner diameter 11.5 mm) at low mass fluxes. The inner surface of the EHT tube is enhanced by dimple/protrusion and secondary petal arrays

Dry season forage assessment across senegalese rangelands using earth observation data

Strengthening of feed security in the Sahel is urgently needed given the climate change and growing human population. A prerequisite to this is sustainable use of rangeland forage resources for livestock. Many studies have focused on the assessment of rangeland resources during the rainy season, while only a few have focused on the dry season which is the longest and most demanding period for live

Enhanced remote sensing of water surface elevation through fusion of Sentinel-3 altimeter data and climate variables using machine learning

Accurate and continuous monitoring of inland surface‌ water dynamics is vital for sustainable water resource management, climate impact assessment, and ecological planning. This study introduces a machine learning-based remote sensing-based data-fusion framework that improves Sentinel-3 radar altimeter (SRAL) estimations of water surface elevation (WSE) by integrating ERA5 reanalysis climate varia

Specific and efficient peptide substrates for assaying the proteolytic activity of prostate-specific antigen

Prostate-specific antigen (PSA) is a serine protease secreted by hath normal prostate glandular celts and prostate cancer cells. The major proteolytic substrates for PSA are the gel-forming proteins in semen, semenogelin (Sg) I and II. On the basis of the PSA cleavage map for Sg I and II, a series of small peptides (ie., ≤ 7 amino acids) was synthesized and coupled at the COOH terminus to 7-amino-

Investigating Ancient Agricultural Field Systems In Sweden From Airborne Lidar Data By Using Convolutional Neural Network

Today, the advances in airborne LIDAR technology provide high-resolution datasets that allow specialists to detect archaeological features hidden under wooded areas more efficiently. Still, the complexity and large scale of these datasets require automated analysis. In this respect, artificial intelligence (AI)-based analysis has recently created an alternative approach for interpreting remote sen

Pollination deficits and their relation with insect pollinator visitation are cultivar-dependent in an entomophilous crop

Insects contribute considerably to global crop pollination, with pollination deficits being documented for multiple entomophilous or pollinator-dependent crops. Different cultivars of crops are being cultivated within and across production regions, so it is essential to understand the cultivar variability of pollination deficits. Here, we used a dataset from 286 sites from multiple production regi

Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain.

Neural stem cells (NSCs) derived from human fetal striatum and transplanted as neurospheres survive in stroke-damaged striatum, migrate from the implantation site, and differentiate into mature neurons. Here, we investigated how various steps of neurogenesis are affected by intrastriatal transplantation of human NSCs at different time points after stroke and with different numbers of cells in each

New injection recommendations for patients with diabetes.

AIM: Injections administered by patients are one of the mainstays of diabetes management. Proper injection technique is vital to avoiding intramuscular injections, ensuring appropriate delivery to the subcutaneous tissues and avoiding common complications such as lipohypertrophy. Yet few formal guidelines have been published summarizing all that is known about best practice. We propose new injecti

Methane dynamics in northern wetlands: Significance of vascular plants

Popular Abstract in Swedish Metan är en växthusgas med stor potential att påverka klimatet på Jorden. Den vattenmättade miljön i våtmarker erbjuder perfekta livsbetingelser för metanproducerande bakterier och detta medför att naturliga våtmarker är den största enskilda källan till metan i atmosfären, även då man räknar med antropogena utsläpp från, till exempel, förbränning av fossila bränslen. MoThe studies presented in Papers I to VI illustrate several different aspects of the impact of vascular plants on methane emissions from northern natural wetlands. The subject has been approached on different scales, ranging from the study of microbial substrates in the vicinity of a single plant root, to an attempt to extrapolate some of the results to the entire northern hemisphere north of 50°N.

C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend.

C4b-binding protein (C4BP) is best known as a potent soluble inhibitor of the classical and lectin pathways of the complement system. This large 500kDa multimeric plasma glycoprotein is expressed mainly in the liver but also in lung and pancreas. It consists of several identical 75kDa α-chains and often also one 40kDa β-chain, both of which are mainly composed of complement control protein (CCP) d

Constraints on Earth System Functioning at the Paleocene-Eocene Thermal Maximum From the Marine Silicon Cycle

The Paleocene-Eocene Thermal Maximum (PETM, ca. 56 Ma) is marked by a negative carbon isotope excursion (CIE) and increased global temperatures. The CIE is thought to result from the release of 13C-depleted carbon, although the source(s) of carbon and triggers for its release, its rate of release, and the mechanisms by which the Earth system recovered are all debated. Many of the proposed mechanis

Estimation of high-resolution terrestrial evapotranspiration from Landsat data using a simple Taylor skill fusion method

Estimation of high-resolution terrestrial evapotranspiration (ET) from Landsat data is important in many climatic, hydrologic, and agricultural applications, as it can help bridging the gap between existing coarse-resolution ET products and point-based field measurements. However, there is large uncertainty among existing ET products from Landsat that limit their application. This study presents a

Spectral light absorption by ambient aerosols influenced by biomass burning in the Amazon Basin. I : Comparison and field calibration of absorption measurement techniques

Spectral aerosol light absorption is an important parameter for the assessment of the radiation budget of the atmosphere. Although on-line measurement techniques for aerosol light absorption, such as the Aethalometer and the Particle Soot Absorption Photometer (PSAP), have been available for two decades, they are limited in accuracy and spectral resolution because of the need to deposit the aeroso

Skaa15 termin 5 2021 0

Kursguide - Course Syllabus • • • • Fastställande Kursplanen är fastställd av Institutionsstyrelsen vid Teaterhögskolan i Malmö 2019-09- 04 att gälla från och med 2020-08-31, höstterminen 2020. Allmänna uppgifter Obligatorisk kurs inom programmet Konstnärligt kandidatprogram i skådespelarkonst.  Undervisningsspråk: Svenska Därtill kan andra skandinaviska språk och engelska förekomma. Kursens mål S

https://www.thm.lu.se/sites/thm.lu.se/files/2021-01/skaa15_termin_5_2021_0.pdf - 2026-05-07

20240125 SWINNO 1889-1969, 1970-2022

SWINNO 1970-2022 Collection SINNO ID Innovation name in Swedish Innovation name in English Description in Swedish Notes for data users Type Product code Artifactual complexity Developmental complexity Year of commercialization Commissioner Novelty from firm perspective Novelty from market perspective Literal name of innovating firm ; SINNO's common name ; SINNO ID Location Firm only produces the i

https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-04/20240125%20SWINNO%201889-1969,%201970-2022.xlsx - 2026-05-07

Leverantör/Avtalsperiod

OBS! Från och med 1 juli 2025 är det Dustin AB som är vår licensförsörjningspartner Programförmedlingen: LeverantörerFöljande är en översikt över våra leverantörer och de vanligaste programmen från respektive leverantör.Om betalning – rapporteringSe till att du har en licens före installation. Nya licenser genererar en faktura till aktuellt kostnadsställe.LeverantörerPausit ABManual PCManual MacAv

https://www.it.lu.se/tjanster/programformedlingen/leverantoravtalsperiod - 2026-05-07

Microsoft Word - Rosengårdssvensk fonetik och fonologi.doc

Microsoft Word - Rosengårdssvensk fonetik och fonologi.doc Petra Bodén ”Rosengårdssvensk” fonetik och fonologi∗ 1. Introduktion 1.1 Övergripande syfte och översikt På 80-talet uppmärksammade Ulla-Britt Kotsinas oss på den nya svenska som börjat talas av ungdomar i Rinkeby, en förort till Stockholm med en hög andel invånare med utländsk bakgrund (Kotsinas 1985, 1988). Kotsinas riktade vår uppmärksa

https://projekt.ht.lu.se/fileadmin/_migrated/content_uploads/Nordlund_Bode__n.pdf - 2026-05-07