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Mot smartare cellgiftsbehandling: Att förebygga behandlingsresistens vid äggstockscancer Äggstockscancer är den dödligaste gynekologiska cancertypen och kräver alltför många liv eftersom tumörer ofta blir resistenta mot behandling – särskilt mot cisplatin, vårt främsta försvar. För att rädda fler liv måste vi förstå hur denna resistens utvecklas och hur vi kan överlista den. I mitt examensarbete Ovarian cancer is the deadliest gynaecologic malignancy, with most patients diagnosed at an advanced stage and facing poor long-term survival. Resistance to cisplatin-based chemotherapy is a major clinical obstacle, yet its proteomic drivers remain poorly defined. In this study, I applied data-independent acquisition mass spectrometry with DIA-NN data processing to analyse one parental and two cis

Plants need light to convert earbon dioxide to organic compounds, but when exposed to too much light the photosynthetic machinery takes damage. This is prevented by conversion of violaxanthin to zeaxanthin, which participate in a process that converts the excess light into heat. The conversion of violaxanthin to zeaxanthin is done by the enzyme violaxanthin de-epoxidase. VDE from spinach have bee

GLOWKeynote Constraining Local Dislocation dialect-geographically Gertjan Postma Meertens Instituut Amsterdam gertjan.postma@meertens.knaw.nl GLOW-36, Lund, 3-5 April 2013 V-T-AGR versus V-AGR-T in Dutch dialects 1 Structure • The problem: order reversal - syntax or postsyntax? • The role of dialectology • Deviant structures V-pron-T and V-AGR-T in Dutch • A fundamental isogloss cuts the Dutch dia

https://konferens.ht.lu.se/fileadmin/user_upload/sol/ovrigt/konferens_glow36/Handouts_and_Presentations/Postma.pdf - 2026-05-18

Background Anti-interleukin (IL)-4Rα monoclonal antibodies (mAb) improve lung function and decreasethe number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement ofearly innate immune responses underlying these treatment effects is not well known. We sought tounderstand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells (BECs) fromCBackgroundAnti-IL-4Rα monoclonal antibodies (mAb) improve lung function and decrease the number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement of early innate immune responses underlying these treatment effects is not well known. We sought to understand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells from COPD patients under

L'homme a la habite un petit îl dans une petite maison. Il reste dans son chaise. C'est une grande mer. Le soleil et le fleurs est beau. Il a une bateau. C'est va deux personnes aves deux chiens. Bonjuor ca va, l'homme dire. Bonjour, ca va bien! C'est le monsieurs responde. Le monsieurs ont une question. Ils fait une affaire. Ils ont un usine sur son îl. Un jour est vont cinq monsieurs sur le vélo

https://projekt.ht.lu.se/fileadmin/user_upload/project/cefle/textes/le_sous-corpus_longitudinal/barbara/Texte_1.txt - 2026-05-18

Hemicelluloses account for 25-30% of total wood dry weight. Mannan-based polysaccharides are the major component of softwood hemicelluloses. They are characterized by their β-1,4-glycosidic linked backbone composed of mannose or a combination of mannose and glucose residues. The backbone can be substituted by α-1,6-linked galactose residues. β-mannanases cleave the internal β-1,4-glycosidic bonds

OBJECTIVE: Mapping coreceptor epitopes used by the prototypic R5 and X4 strains, HIV-1BaL and HIV-1IIIB, in comparison with epitopes involved in the activation and signaling induced by the natural ligands, RANTES and SDF-1beta. DESIGN: Receptor hybrids between CCR5 and CXCR4 were constructed. METHODS: Using single-overlap and extension PCR, increasing portions of CCR5 were replaced with correspond

BackgroundDuring bacterial infections of the airways, a Th1-profiled inflammation promotes the production of several host defense proteins and peptides with antibacterial activities including -defensins, ELR-negative CXC chemokines, and the cathelicidin LL-37. These are downregulated by Th2 cytokines of the allergic response. Instead, the eosinophil-recruiting chemokines eotaxin-1/CCL11, eotaxin-2

Diamond–Blackfan anemia (DBA) results from haploinsufficiency of ribosomal protein subunits in hematopoietic progenitors in the earliest stages of committed erythropoiesis. Nemo-like kinase (NLK) is chronically hyperactivated in committed erythroid progenitors and precursors in multiple human and murine models of DBA. Inhibition of NLK activity and suppression of NLK expression both improve erythr

How do we describe a location on earth? How do we describe a location on Earth? Geodetic reference system http://www.google.co.uk/imgres?imgurl=http://4.bp.blogspot.com/-v2sej--Hf9Y/TbGzN0FeN7I/AAAAAAAAAQ0/dXTA6XAP7Nk/s1600/earth-3d.gif&imgrefurl=http://ods-destruction-carbon-credits.blogspot.com/2011/04/happy-earth-day-from-remtec.html&usg=__1-2G0CU8X0-43x3j7NY4oN1vYS8=&h=1024&w=1024&sz=266&hl=en

https://www.nateko.lu.se/sites/nateko.lu.se/files/field2.pdf - 2026-05-20

BACKGROUND: Subtelomeric regions are gene rich and deletions in these chromosomal segments have been demonstrated to account for approximately 2.5% of patients displaying mental retardation with or without association of dysmorphic features. However, cases that report de novo terminal deletions on chromosome arm 15q are rare. METHODS: In this study we present the first example of a detailed molecu