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Aims Gene fusions assays are key for personalised treatments of advanced human cancers. Their implementation on cytological material requires a preliminary validation that may make use of cell line slides mimicking cytological samples. In this international multi-institutional study, gene fusion reference standards were developed and validated. Methods Cell lines harbouring EML4(13)–ALK(20) and SL

Objective Two functional single nucleotide polymorphisms (SNP) in the PTPN22 gene (rs24746601 and rs33996649) have been associated with autoimmunity. The aim of this study was to investigate the role of the R263Q SNP for the first time and to re-evaluate the role of the R620W SNP in the genetic predisposition to systemic sclerosis (SSc) susceptibility and clinical phenotypes. Methods 3422 SSc pati

The incretin hormone glucagon-like peptide 1 (GLP-1) promotes glucose homeostasis and enhances -cell function. GLP-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, which inhibit the physiological inactivation of endogenous GLP-1, are used for the treatment of type 2 diabetes. Using the Metabochip, we identified three novel genetic loci with large effects (30-40%) on G

Excited states of the neutron deficient Ag-101 nucleus have been investigated via the Cr-50(Ni-58, 3rho1alpha) heavy-ion induced reaction at 261 meV by use of in-beam spectroscopic methods. On the basis of the measured gammagamma-cincidence relations and angular distribution ratios high-spin bands have been extended up to I-pi = 35/2(+), 45/2((-)) and (49/2(-)). The negative parity states at the h

Popular Abstract in Swedish Personer, särskilt äldre, som vårdas på sjukhus kan under vårdtiden utveckla ett tillfälligt förvirringstillstånd (akut konfusion, ACS). Tillståndet är ofta förenat med obehag för patienten och efteråt ber de ibland vårdarna om ursäkt för sitt beteende. Det är därför angeläget att vårdarna har en uppfattning om hur de skall förhålla sig till patientens förvirrade beteenThe aims of this thesis were to investigate factors of significance for the development of acute confusional state (ACS), the confusional episodes, the lived experiences of having been confused in elderly patients admitted for emergency or elective surgery in orthopaedic care. A further aim was to investigate the nurses’ view of the ACS and the encounter with patients who developed ACS. A case stu

Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim of the present study was to investigat

There is a large body of evidence that atomic nuclei can undergo octupole distortion and assume the shape of a pear. This phenomenon is important for measurements of electric-dipole moments of atoms, which would indicate CP violation and hence probe physics beyond the Standard Model of particle physics. Isotopes of both radon and radium have been identified as candidates for such measurements. Her

Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs that is among the highest known for cancers1. However, only a limited number of genetic risk loci ha

BACKGROUND: Patients with severe aortic stenosis (AS) often have coronary artery disease. Both the aortic valve and the coronary disease influence the blood flow to the myocardium and its ability to respond to stress; leading to exertional symptoms. In this study, we aim to quantify the effect of severe AS on the coronary microcirculation and determine if this is influenced by any concomitant coro

The goal of the GHG-CCI project (http://www.esa-ghg-cci.org/) of ESA's Climate Change Initiative (CCI) is to generate global atmospheric satellite-derived carbon dioxide (CO2) and methane (CH4) data sets as needed to improve our understanding of the regional sources and sinks of these important greenhouse gases (GHG). Here we present an overview about the latest data set called Climate Research Da

Revised recommendations for the names and symbols of the transfermium elements(atomic numbers 101-109) are presented along with the reasons for proposing them. The recommendations (ref. 1) of the Commission on Nomenclature of Inorganic Chemistry (CNIC) on the nomenclature of the transfermium elements (101-109, inclusive) were considered by the IUPAC Bureau at Guildford (UK) in September 1995. As a result of the various criticisms of the recommendations and theway that they had been processed, the Bureau decided to adopt the recommendations as provisional

Tau neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer’s disease (AD). To elucidate patterns of structural change in the MTL specifically associated with tau pathology, we compared high-resolution ex vivo MRI scans of human postmortem MTL specimens with histology-based patho

Background: Perioperative complications can affect outcomes after gastrectomy for cancer, with high mortality and morbidity rates ranging between 10 and 40%. The absence of a standardized system for recording complications generates wide variation in evaluating their impacts on outcomes and hinders proposals of quality-improvement projects. The aim of this study was to provide a list of defined ga

Background: The Earth Hologenome Initiative (EHI) is a global endeavor dedicated to revisit fundamental ecological and evolutionary questions from the systemic host–microbiota perspective, through the standardized generation and analysis of joint animal genomic and associated microbial metagenomic data. Results: The first data release of the EHI contains 968 shotgun DNA sequencing read files conta

Purpose: Humoral immunity proteins—immunoglobulins, complement proteins, and antimicrobial peptides—have key antimicrobial and immunomodulatory functions in sepsis. We hypothesised that their circulating levels are lower in non-survivors, potentially resulting in impaired bacterial clearance and persistent or recurrent infections. Methods: We performed a systematic review and meta-analysis evaluat

Nya horisonter HUMANIST- OCH TEOLOGDAGARNA | 14 –15 APRIL 2023 2 3 Nya horisonter En rymdsond med namnet New Horizons sändes ut 2006 med siktet inställt på Kuiperbältet – en jordnötsformad region bortom Neptunus bana som sägs innehålla de bäst bevarade spåren av det tidiga solsystemet. Bilderna den sände oss från Pluto nio år senare var enastående. Sonden förändrade för en stund våra horisonter, b

https://www.ht.lu.se/fileadmin/user_upload/ht/bilder/Samverkan/HT-dagarna/HT-dagarna_Nya_horisonter_webbversion_med_rausing.pdf - 2026-04-06

Transport Biofuels in Sweden: Joanne Morris Transport Biofuels in Sweden 16 May 2011 1 Transport Biofuels in Sweden: Stakeholders’ perceptions of the Renewable Energy Directive’s governance of the industry by Joanne Morris Supervisor: Sara Brogaard (LUCSUS) Co-supervisor: Bodil Elmqvist (LUCSUS) A Thesis submitted to Lund University in partial fulfillment of the requirements for the degree of MAST

https://www.lumes.lu.se/sites/lumes.lu.se/files/morris_joanne_thesis_2011.pdf - 2026-04-25

Sheet1 Check for order Analysis Variable Units Comment Instrument Analysis version Average result Standard deviation Count positive Count negative Percentage Positive Total Internal Identifier, analysis Internal Identifier, variable Always included ParticipantId Participant identifier ParticipantId Visit-age calculation Participant age at visit Visit-age calculation Gender Participant gender CRM.G

https://www.epihealth.lu.se/sites/epihealth.lu.se/files/physical_measurement_variables_1.0.2.xls - 2026-04-25