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Endometrial cancer off-line staging using two-dimensional transvaginal ultrasound and three-dimensional volume contrast imaging : Intermethod agreement, interrater reliability and diagnostic accuracy

Objectives: The aim is to estimate agreement between two-dimensional transvaginal ultrasound (2D-TVS) and three-dimensional volume contrast imaging (3D-VCI) in diagnosing deep myometrial invasion (MI) and cervical stromal involvement (CSI) of endometrial cancer and to compare the two methods regarding inter-rater reliability and diagnostic accuracy. Methods: Fifteen ultrasound experts assessed off

Transcript expression-aware annotation improves rare variant interpretation

The acceleration of DNA sequencing in samples from patients and population studies has resulted in extensive catalogues of human genetic variation, but the interpretation of rare genetic variants remains problematic. A notable example of this challenge is the existence of disruptive variants in dosage-sensitive disease genes, even in apparently healthy individuals. Here, by manual curation of puta

Putting nature to work

The idea for nature based research design emerged in preparation of a workshop and subsequent exhibition regarding minimal surfaces, supervised by Andreas Hopf, Senior Lecturer at Lund University School of Industrial Design, and supported by Prof. Dr. Konrad Polthier (Chair Mathematical Geometry Processing, FU Berlin) at the DESIGNMAI digital crafts event in Berlin in 2007, for which Swedish desig

Positive Response to Cardiac Resynchronization Therapy : The Role of NT-proBNP

Abstract Background: Cardiac resynchronization therapy (CRT) is effective, but only 60-70% of patients benefit from the therapy. Despite numerous implantations, identification of predictive factors for response is still a challenge. We sought to assess the correlation of echocardiographic and clinical response to baseline demographics in relation to change in NT-proBNP levels at 6 months. Methods:

Reverential fear and consent to marriage

According to medieval canon law, a marriage could be declared invalid if the consent had been given through force or fear. This ruling was a natural consequence of the insistence on free consent as the only requirement for a valid marriage. It did, however, entail a number of both practical and theoretical problems. It could be difficult to prove force and fear within the family, but also to defin

Concentration Camp Rituals: An Extreme Case of Insecurity

Reason(s) for writing and research problem(s): This article analyzes the experiences retold by former concentration camp detainees who were placed in concentration camps like civilians at the beginning of the Bosnian war in the 1990s. Aims of the paper (scientific and/or social): The article aims to describe the recounted social interaction rituals after time spent in a concentration camp as well

In search of “Muda” through the TKJ diagram

Purpose: Muda is a Japanese term literally meaning futility, uselessness, idleness, superfluity, waste, wastage or wastefulness. The term was introduced by the Japanese engineer Taiichi Ohno of Toyota Motor Corporation in the 1960s. Therefore, reducing and minimizing Muda is an effective way to increase the operational efficiency and productivity of an organization’s processes. In turn, the techni

Forecasting global atmospheric CO2

A new global atmospheric carbon dioxide (CO2) real-time forecast is now available as part of the pre- operational Monitoring of Atmospheric Composition and Climate – Interim Implementation (MACC-II) service us- ing the infrastructure of the European Centre for Medium- Range Weather Forecasts (ECMWF) Integrated Forecast- ing System (IFS). One of the strengths of the CO2 fore- casting system is that

Functional and phenotypical comparison of myofibroblasts derived from biopsies and bronchoalveolar lavage in mild asthma and scleroderma

Background: Activated fibroblasts, which have previously been obtained from bronchoalveolar lavage fluid (BALF), are proposed to be important cells in the fibrotic processes of asthma and scleroderma (SSc). We have studied the motility for BALF derived fibroblasts in patients with SSc that may explain the presence of these cells in the airway lumen. Furthermore, we have compared phenotypic alterat

Decentraliserad förvaltning av EG:s finanser

När EU:s budget är antagen ligger det övergripande ansvaret på kommissionen att se till att den genomförs i överensstämmelse med principen om god ekonomisk förvaltning. Eftersom gemenskapen inte förfogar över egen tull- och skattemyndighet och för övrigt inte har möjligheter eller resurser att administrera och förvalta den övervägande delen av budgeten sker det genom medlemsstaternas nationella or

Carrier Delay in Multimodal Transport

This research is a critical analysis of a delay regime for multimodal transport, or door-to-door transport. At this day, there are no mandatory rules governing multimodal transport, but a process of creating a set of rules are pending both within UNCITRAL as well as the European Union. Due to the increased use of containers in shipping, multimodal transport has become more common. For this purpose

Kosovo - A Territory with a Right to Self-Determination?

Kosovo, världens 193:e land, blir den sjätte staten som bildats från den serbdominerade jugoslaviska federationen sedan 1991, efter Slovenien, Makedonien, Bosnien och Montenegro som blev världens nyaste stat 2006. Kosovos status som självständig stat är dock fortfarande omstridd. Frågan om Kosovo är ett internationellt subjekt som har en rätt till externt självbestämmande och därmed är ett subjektKosovo, the world’s 193rd country, will be the sixth state carved from the former Serbian-dominated Yugoslav federation since 1991, after Slovenia, Croatia, Macedonia, Bosnia and Montenegro, which became the world’s newest state in 2006. Kosovo’s statehood is, however, still disputed. The question if Kosovo is a subject that has a right to external self-determination and therby hold international

Av den dräpte till vrede retad - offerprovokationens inverkan på den rättsliga bedömningen av våldsbrott

Vid bedömningen av en viss brottslig gärning finns möjlighet att ta hänsyn till offrets kränkande beteende före brottet, eller s.k. provokation. Provokation är en moraliskt komplex fråga. Sättet att se på provokation, liksom vilken genomslagskraft den har fått i den rättsliga bedömningen, har varierat över tid. Uppsatsen har en relativt omfattande teoretisk diskussion runt grunderna för att se lin

Försäkring av häst - vad innebär det och vad finns det för säregna drag?

Det är dyrt att äga en häst, en del av denna kostnad är försäkringspremien. Försäkringen kan dock komma väl till hands då en skada inträffar. Bara för att man har sin häst försäkrad innebär det inte att alla skador hästen kan få är ersättningsbara. Uppsatsen kommer att behandla olika problem vid försäkring av häst. Det finns vissa skillnader mot ''vanliga'' sakförsäkringar. Försäkr

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on European subjects. Methods We performed a two-stage meta-analysis on more than 78 000 participants. In stage 1, we synthesised data from eight GWAS whereas data from 10 centres wer

Quantum memories

We perform a review of various approaches to the implementation of quantum memories, with an emphasis on activities within the quantum memory sub-project of the EU integrated project "Qubit Applications". We begin with a brief overview over different applications for quantum memories and different types of quantum memories. We discuss the most important criteria for assessing quantum memory perfor