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Serine deficiency disorders are caused by a defect in one of the three synthesising enzymes of the L-serine biosynthesis pathway. Serine deficiency disorders give rise to a neurological phenotype with psychomotor retardation, microcephaly and seizures in newborns and children or progressive polyneuropathy in adult patients. There are three defects that cause serine deficiency of which 3-phosphogly
Tracking of rigid and articulated objects is usually addressed within a particle filter framework or by correspondence based gradient descent methods. We combine both methods, such that (a) the correspondence based estimation gains the advantage of the particle filter and becomes able to follow multiple hypotheses while (b) the particle filter becomes able to propagate the particles in a better ma
Production studies show that anaphoric reference is bimodal. Speakers can introduce a referent in speech by also using a localizing gesture, assigning a specific locus in space to it. Referring back to that referent, speakers then often accompany a spoken anaphor with a localizing anaphoric gesture (i.e., indicating the same locus). Speakers thus create visual anaphoricity in parallel to the anaph
In Islamic Modernities in Southeast Asia, Leonie Schmidt provides a thorough analysis of contemporary Islamic-themed popular and visual cultures, mainly in Indonesia. This book is an essential read for those who wish to understand multiple modernities unfolding in post-1998 Indonesia (the Reformasi era). By using the term Islamic, she refers to any ‘cultural practices that are considered bernafask
Intraspecific variation can have important consequences for the structure and function of ecological communities, and serves to link community ecology to evolutionary processes. Differences between the sexes are an overwhelmingly common form of intraspecific variation, but its community-level consequences have never been experimentally investigated. Here, we manipulate the sex ratio of a sexually
The sedimentation of a suspension is a unit operation widely used in mineral processing, chemical engineering,wastewater treatment, and other industrial applications. Mathematical models that describe these processes and may be employed for simulation, design and control are usually given as nonlinear, time-dependent partial differential equations that in one space dimension include strongly degen
This paper presents results of a production experiment testing the recursivity of prosodic realization of focus in Tokyo Japanese. Tokyo Japanese wh-questions obligatorily exhibit focus prosody, which starts from a wh-phrase (WH) and continues until the question particle (Q) that binds the wh-phrase (Deguchi and Kitagawa 2002; Ishihara 2002, 2003). The current study examines the case where one WH–
Many predictive models exist that predict risk of common cardiometabolic conditions. However, a vast majority of these models do not include genetic risk scores and do not distinguish between clinical risk requiring medical or pharmacological interventions and pre-clinical risk, where lifestyle interventions could be first-choice therapy. In this study, we developed, validated, and compared the pe
BACKGROUND: Allergic contact dermatitis (ACD) from protective gloves is often caused by rubber additives, such as accelerators. However, while accelerator-free rubber gloves are available, they still cause ACD in some individuals.OBJECTIVES: A new allergen, 2-cyаnоethyl dimethyldithiocarbamate, (CEDMC), has recently been identified in accelerator-free gloves, and we here provide a first in vitro c
There is currently a great need for rigid, high-performance and processable bio-based polymers and plastics as alternatives to the fossil-based materials used today. Here, we report on the straightforward synthesis and polymerization of lignin-derived methacrylate monomers based on the methyl esters of syringic, vanillic, and 4-hydroxybenzoic acid, respectively. The corresponding homopolymethacryl
Introduction: Whether and under what conditions scientific knowledge provided by experts actually leads to political action is a question that academic research in various fields have focused on at length, without reaching a definitive answer. The position of expertise is especially delicate within the global environmental governance sphere containing multiple values, worldviews and epistemologica
The Rodinia supercontinent broke apart during the Neoproterozoic. Rodinia break-up is associated with widespread intraplate magmatism on many cratons, including the c. 720–719 Ma Franklin large igneous province (LIP) of Laurentia. Coeval magmatism has also been identified recently in Siberia and South China. This extensive magmatism terminates ∼1 myr before the onset of the Sturtian Snowball Earth
