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Background Immunotherapy targeting the amyloid beta (A beta) peptide is a potential strategy to slow the progression of Alzheimer's disease. We aimed to assess the safety and tolerability of CAD106, a novel active A beta immunotherapy for patients with Alzheimer's disease, designed to induce N-terminal A beta-specific antibodies without an A beta-specific T-cell response. Methods We did a phase 1,
AIMS/HYPOTHESIS: The metabolic syndrome is a cluster of factors contributing to increased risk of cardiovascular disease and type 2 diabetes but unifying mechanisms have not been identified. Our aim was to study whether common variations in 17 genes previously associated with type 2 diabetes or components of the metabolic syndrome and variants in nine genes with inconsistent association with at le
The main aim of the present thesis is to demonstrate the efficient quantum memories for light employing coherent processes in rare-earth-ion-doped crystals. Rare-earth (RE) ions between lanthanum, with atomic number 57, and lutetium, with atomic number 71, have a partly filled 4f shell, which is spatially inside the full shells 5s, 5p, and 6s. Therefore, 4f-4f transitions are shielded from environ
Popular Abstract in Swedish I avhandlingsarbetet har spridning av förorenad jord till följd av jordskred till ytvatten studerats genom att sammankoppla faran för miljö och hälsa från förorenad mark med faran för skred. Skredriskbedömningar görs på många håll runt om i världen, likaså riskbedömning av förorenad jord, dock görs dessa helt separerade från varandra och det finns därför väldigt lite inLandslide risk assessments and environmental risk assessments are routinely carried out in many countries exposed to landslide hazards and/or contaminated soil hazards, but separately from each other. By combining results from different types of risk assessments and superimposing the results, possible multi-hazards may be revealed, which is not the case when the results are only displayed independ
This report is about the housing situation in Manila, capital of the Philippines. 25% of the inhabitants in this mega city live in informal settlements, often on places unsuitable for living. The target area of this paper is Baseco, a large slum area near the outlet of Pasig River and home to 47 000 people according to the 2002 census. Among its many problems including overpopulation and poverty i
Background: Fine-needle aspiration biopsy (FNAB) of lymph nodes is a widely used method for evaluating lymphadenopathy. FNAB offers general advantages of rapid turnaround time, low cost and minimal morbidity, and more specific advantages in various clinical situations, such as deeply located lymph nodes or patients with significant comorbidities. The FNAB sample can be utilized for a wide range of
Popular Abstract in Swedish Hjärt-kärlsjukdom är en av västvärldens stora folksjukdomar. I Sverige drabbas årligen cirka 10 000 personer av plötsligt hjärtstopp. Den vanligaste orsaken är att en akut hjärtinfarkt orsakar ett ”elektriskt kaos” i hjärtat. Vid ett hjärtstopp upphör blodförsörjningen till hjärnan, vilket leder till medvetslöshet inom några sekunder och inom några få minuter börjar hjäThis thesis focuses on the prognostic value of electroencephalography(EEG) in comatose patients resuscitated after cardiac arrest (CA), using both simplified continuous EEG monitoring (cEEG) and routine EEG. Background: Comatose survivors are admitted to an intensive care unit (ICU) to support vital functions. Postresuscitation care includes target temperature management (TTM) for 24 hours. The d
In this work conformational studies have been performed on peptides from four different systems in an attempt to gain knowledge about their biological function. Circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy in combination with distance geometry and restrained molecular dynamics simulations were the methods used. A detailed conformational study of a cyclic p
The Proton Exchange Membrane (PEM) fuel cell has been investigated for a long time, and is regarded as a new energy source for various applications, such as portable, stationary and automotive ones. However, due to the shortage of the infrastructure in the society, the high cost, the difficulty of the water/thermal management, etc., practical systems have not reached the general public, yet. Of t
Popular Abstract in Swedish Stroke utgör den tredje vanligaste dödsorsaken i västvärlden och är dessutom huvudorsak till långvarigt handikapp hos vuxna individer. Det stora antalet överlevande men handikappade individer utgör ett omfattande problem för samhället inte bara i form av ekonomiska resurser utan även vad gäller personliga trauma. Den kliniska termen stroke omfattar patologiska tillståndStroke is the most common life-threatening neurological disease and ranks as the third leading cause of death in major industrialized countries. It is also the leading cause of serious long-term disability and about sixty percent of survivors have disabilities in their extremities. Recovery of certain neurological functions occurs over time, which has been attributed to endogenous restorative proc
The rugged field and group of trees between housing estates or next to the railroad tracks, the left-over space of deserted industrial areas, the vacant demolition site of a central city block – they could all be termed ‘urban voids’. However, they are often anything but voids, in a literal sense, as they are not empty, or deserted. Yet they are ‘urban voids’, lacking an evident function, or a
The characterization of naturally occurring mutations is one way to approach functionally significant domains of polypeptides. About 10 mutations have been reported in factor XIII (FXIII) A-subunit deficiency, but very little is known about the effects of the mutations on the expression or the structure of this enzyme. In this study, the recent crystallization of FXIII A-subunit and determination
Recent work on heritage and social media has highlighted how social media offer new possibilities for citizens to share memories, identities, local culture and heritage, and thus constitute a more participatory and democratic platform (Giaccardi 2012). Social media encourage and enable new forms of engagement and interpretations of the heritage through user-generated content, personal reflections,
The product price given when producing offshore is not the entire truth and more companies decide to move their offshore production nearshore (Stentoft et. al, 2016). To measure the actual cost of producing many more parameters than visible costs needs to be taken account for. There are advantages as well as risks with outsourcing and costs can increase with distance such as quality issues, freigh
De senaste tio åren har antalet sökta bygglov för småhus med träregelstomme mer än fördubblats. I dagsläget finns inget allmänt krav att säkerställa horisontalkapacitet för småhus men är något som beställaren kan efterfråga och som många konstruktörer någon gång upplevt problematiskt. Projekteringsfasen kan bli tidskrävande där lösningar för att fastställa kapacitet mot vindlast blir dyra och kompIn the last ten years, the number of building permits applied for houses with timber frame structure has more than doubled. Today, there is no general requirement to establish horizontal capacity, but is something that can be demanded and that many structural engineers have occasionally experienced as problematic. The design phase can then be time-consuming, where solutions for determining capacit
Punktlighet och förseningar inom järnväg är något som står högt upp på agendan i dagens samhälle. Med en infrastruktur som är i ett stort behov av underhåll samtidigt som trycket på klimatsmarta transportlösningar bara ökar, blir punktligheten och framkomligheten inom järnvägen avgörande. Med en total punktlighet på ungefär 90% finns det mycket att göra. En av järnvägens infrastrukturproblem är spPunctuality and delays within the railway system are of utmost concern in today’s society. With an infrastructure in a dire need of maintenance and the increasing pressure for environmentally friendly transportation solutions, punctuality and accessibility within the railway system becomes crucial. With an overall punctuality rate of approximately 90%, there is much to be improved. One of the prob
This thesis explores how the handling, analysis and transformations of material and data affect the production of knowledge in an applied project of cultural analysis. It concerns itself mainly with the process of dislocation, transformation and transportation of meaning, by putting to work the actor-network theories of Bruno Latour. An attempt will be made to retrace the steps of creating materia
Deoxygenation, i.e. loss of oxygen from the oceans, often considerably influences the aquatic organisms and the wholeecosystem and changes biogeochemical cycles. It results in increasing bottom areas of hypoxia (<2 mg/l dissolved oxygen),which has been primarily attributed to global warming and increased eutrophication. It is vital to study the present-dayanthropogenically-induced environmental ch
Background Direct cell reprogramming is characterized by the use of defined factors to rewire the transcriptional and epigenetic network of one cell-type into one of a different lineage. We have recently identified the transcription factors PU.1, IRF8, and BAFT3 (PIB) as sufficient to induce a type 1 conventional dendritic cell (cDC1) fate in both somatic and cancer cells.1,2 cDC1 is a rare dendri
The 2015 Paris Agreement of the United Nations Framework Convention on Climate Change aims to keep global average temperature increases well below 2 °C of preindustrial levels in the Year 2100. Vital to its success is achieving a decrease in the abundance of atmospheric methane (CH4), the second most important anthropogenic greenhouse gas. If this reduction is to be achieved, individual nations mu
