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Popular science summary: Transcriptional regulation of HIF-2α in neuroblastoma Neuroblastoma is the most common solid tumor in childhood. The presence of hypoxia -regions of low levels of oxygen- causes a more immature tumor phenotype that is related to a more aggressive form of this cancer. Hypoxia is mainly directed by Hypoxia Inducible Factors (HIF)-1α and HIF-2α. High levels of HIF-2α expre
Hydrauliska parametrar är viktiga att kunna mäta i samband med stadsplanering, prospektering och för att få fram information om hur en möjlig föroreningstransport genom jordlager och berggrund skulle kunna ske. Slugtest är ett enkelt akvifertest som tar fram värden på formationens genomsläpplighet och har flera fördelar jämfört med andra akvifertester. I denna studie berörs grundvattenrör med liteHydraulic analysis plays a crucial role in urban planning, prospecting and environmetal assess-ments. Slug test is an aquifer test often used by hydrogeologist and engineers to determine the hydraulic conduct-ivity. In this bachelor thesis I discuss aquifers with small diameter piezometers where some of the them are screened across the water table. The essay is conducted in cooperation with the su
The average woman uses 11,000 tampons during her lifetime. Both sanitary pads and tampons have been proven to contain low levels of dioxins, which are a group of highly toxic environmental pollutants known to cause cancer, reproductive damage and endocrine disruption. Some scientists have concluded that dioxin levels in tampons are insignificant to the overall dioxin exposure of menstruating women
It is well established that bumblebees play a vital role in the ecosystem, not only as pollinators but as providers of other ecosystem services. Thus, it is important to have a good understanding of their habitat requirements and ecology. Bumblebees can learn to associate floral cues with rewarding and unrewarding flowers. The availability of resources in flowers is very dynamic as it varies durin
Följande rapport utfördes för att utvärdera och validera brandskyddet på Bäcklidens demensboende i Tibro kommun. Rapporten har behandlat att skydda människors liv och hälsa. Egendomsskydd samt ekonomiska aspekter har därför inte värderats in. Bäckliden är ett av Tibro Kommuns särskilda boenden som är utformad för dementa individer där alla boende behöver någon form av assistans för att utrymma. I The following report was conducted to evaluate and validate the fire protection at Bäckliden's dementia care home in Tibro municipality. The report has dealt with the protection of people's lives and health. Property protection and economic aspects have therefore not been evaluated. Bäckliden is one of Tibro Municipality's special accommodations designed for demented individuals where
As society becomes more ecologically conscious there is a push toward the use of materials with a smaller environmental burden, one of these materials is glulam (GLT), which has gained a lot of traction in recent years not only for ecological reasons but for its ease in manufacture, transport, noise dampening, etc. The focus of this project was to evaluate the influence of different joint configu
The aim of this thesis is to widen the research field of archival law in relation to the new technological opportunities that have been created regarding personal information such as DNA. This is done by the study of the three most influential and popular biotechnical companies that are currently offering their services in Sweden. The material used to achieve this aim is GDPR and the privacy state
Microalgae belong to the group of the oldest microorganisms that can grow in both fresh and marine water. Microalgal biomass is a rich source of vitamins, lipids, pigments and essential amino acids. Microalgal biomass can be used without cracking and fractionation or it can be cracked, fractionated and purified to get particular components like vitamins, pigments, omega-3 oils and proteins. But du
Industrialization has been the key engine for economic growth in the developed world, and currently these economies are substituting away from manufacturing towards services. The alarming trend is that developing countries are doing so as well to an even greater extent and at a lower level of GDP and development. This phenomenon of deindustrialization is premature for developing economies as they
This thesis discusses the landscape changes of Helsingborg municipality in Scania, southern Sweden. The aim of this thesis is to compare the occurrence of wetlands in the early 1800’s with the contemporary occurrence. The findings will be presented from three angles: the total wetland area, presence of different wetland types, and spatial distribution of the wetlands. To assess this change over ti
Cartographic mashups present geographic data from various sources. A typical example is adding thematic data on top of a multi-scales background map. Currently, thematic data and multi-scales background data are not linked together in cartographic mashups which may have potential problems such as inconsistency of scale ranges. However, in some cases, thematic data and background data have some ide
Den svenska straffrätten har under det senaste århundradet genomgått en mängd förändringar. Allt som oftast har påföljdssystemet varit utformad efter de för tillfället förhärskande bestraffningsteorierna. Det finns en lång tradition av särbehandling av unga lagöverträdare i Sverige och till viss del så tas hänsyn till andra intressen när det gäller ungdomar. Denna framställning ska besvara frågornSwedish penal law has undergone many changes over the last centuries. The sanction system has most often been modelled on penalization theories dominant at the time. Sweden has a long tradition of special treatment of young offenders, and other interest are to some extent taken into consideration when it comes to juvenile offenders compared to adults. This essay will answer the questions of which
Microbial activity in soil is usually limited by the availability of carbon (C). Adding an easily available C source, like glucose, has therefore been a common approach to study alleviation of resource limitations. Most such studies have relied on respiration to study microbial dynamics, with few following the explicit growth response. We determined the response in bacterial and fungal growth, as
Background and Purpose-High-dose heparin has been used extensively to treat patients with progressive ischemic stroke, but the scientific support is poor and the current stroke guidelines advise against its use. We studied how heparin treatment for progressive stroke has been discarded in Sweden. Methods-All 78 hospitals in Sweden that admit acute stroke patients participate in Riks-Stroke, the Sw
The work presented here is based on two papers, both pertaining to perturbation-based control strategies in industrial fed-batch fermentation processes. The first paper describes a new control strategy for avoiding overflow metabolism in the exponential growth phase of a fermentation, based on analysis of the frequency spectrum of the dissolved oxygen measurement following a periodic perturbation
All notified MRSA cases in SkAyenne County have been followed since 2000. We have investigated the MRSA epidemiology over time, method of acquisition, whether some spa types are more prone to spread, and/or cause more infections, and the connection between spa type and country of acquisition/origin. All cases between 2000 and 2010 were included. Infection or colonization and the presence of PVL ge
Background: The presence of echolucent carotid plaques as defined by low ultrasound grey-scale median (GSM) is associated with a higher risk of stroke and myocardial infarction. Betablockers have shown possible anti-atherosclerotic effects. The aim of the present study was to determine if there is an association between carotid plaque GSM and treatment with betablockers. Methods: The GSM of the ca
Objective This study assessed pesticide exposure of children in rural Nicaragua in relation to parental pesticide use, from around conception to current school age, as part of an epidemiological evaluation of neurodevelopment effects. Methods We included 132 children whose parents were subsistence farmers or plantation workers, or had an agricultural history. As proxies for children's long-term ex
An unbalanced chromosome number (aneuploidy) is present in most malignant tumours and has been attributed to mitotic mis-segregation of chromosomes. However, recent studies have shown a relatively high rate of chromosomal mis-segregation also in non-neoplastic human cells, while the frequency of aneuploid cells remains low throughout life in most normal tissues. This implies that newly formed aneu
Miljöproblemen har länge varit ett aktuellt och omtalat diskussionsämne som man aktivt jobbat för att begränsa och minska människans negativa klimatpåverkan med målsättningar samt nya lagar och krav. Byggsektorn står idag för en betydande del av Sveriges koldioxidutsläpp och för att ha möjlighet att uppnå de mål som finns i Parisavtalet krävs åtgärder i byggbranschen. Klimatneutralitet är ett relaThe environmental problems have for a long time been a current and highly spoken topic of discussion which one has actively worked to limit and reduce the human's negative climate impact with agreements, laws and requirements. Today the constructions sector stands for a significant part of Sweden's carbon dioxide emissions and to be able to achieve the goals in the Paris Agreement, measure
