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A new encapsulation strategy for probiotics is highly needed to tackle the challenge of significant viability loss of bacteria during storage and passage through the gastrointestinal system. A new controlled delivery system for probiotics based on EC oleogels is proposed in this thesis. A relatively non-complicated in vitro lipolysis model was established to evaluate the relative conversion from t
BACKGROUND: Some autoimmune disorders have been linked to venous thromboembolism. We examined whether there is an association between autoimmune disorders and risk of pulmonary embolism. METHODS: We followed up all individuals in Sweden without previous hospital admission for venous thromboembolism and with a primary or secondary diagnosis of an autoimmune disorder between Jan 1, 1964, and Dec 31,
The role of multiple groups of primary biological aerosol particles (PBAPs) as ice nucleating particles (INPs), and of ice formation processes such as time-dependent freezing of various INPs, and various secondary ice production(SIP) mechanisms in overall ice concentration has been evaluated in a range of cloud systems by simulating them numerically with the state-of-the-art ‘Aerosol-Cloud’ (AC) m
Background: The use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) has been associated with reduced relapse rates and accumulation of disability. However, studies examining impact of DMT on risk of transition to secondary progressive MS (SPMS) leveraging population-based nationwide data are still rare. Here, we determine the population incidence of conversion to SPMS using two co
Objective: The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) predicts mortality and damage accrual in systemic lupus erythematosus (SLE), but its association with hospitalizations has not been described. Our objective was to estimate the association of baseline SLICC-FI values with future hospitalizations in the SLICC inception cohort. Methods: Baseline SLICC-FI sco
Groundwater footprint index (GFI) is an essential indicator to assess the sustainability of groundwater aquifers. Prediction of future GFI can significantly help managers and decision-makers of groundwater supply to better plan for future resilient consumption of surface and groundwater. In this context, artificial intelligence and machine learning models can aid to predict GFI in view of lacking
BACKGROUND: The use of viscoelastic tests is becoming increasingly popular. There is a paucity of validation of the reproducibility of varying coagulation states. Therefore, we aimed to study the coefficient of variation (CV) for the ROTEM EXTEM parameters clotting time (CT), clot formation time (CFT), alpha-angle and maximum clot firmness (MCF) in blood with varying degrees of coagulation strengt
The purpose of the research presented in this thesis is to enhance the field of accessibility to include a multitude of perspectives. Based on cultural-historical activity theory (CHAT), it analyzes how human, artifactual and natural factors impact an individual’s possibilities to act in concrete situations that are part of a systemic whole.The thesis presents two main results:An enhanced accessib
Biofuel production in the world has grown exponentially, stimulated by public policies, in countries of the North as well as of the South, and has been seen as one of the main drivers behind the recent food price hike. Thus conflicts over land need to be factored in when biofuels are assessed. Nowhere in the world is biofuel production seen to be more successful – economically, ecologically – than
Background: Proton radiotherapy (RT) is an attractive tool to deliver local therapy with minimal dose to uninvolved tissue, however, not suitable for all patients. The aim was to explore complications, especially severe late complications (grades 3–4), following proton RT delivered to a complete Swedish cohort of paediatric patients aged <18 years treated 2008–2019. Material and Methods: Data was
Immunoglobulin G4-related disease (IgG4-RD), which was initially identified as a type of autoimmune pancreatitis around the year 2000, is now widely acknowledged to be a systemic sickness. Based on both general and organ-specific criteria, alongside laboratory measurements of IgG4-subtype, the diagnosis is made. The diagnosis requires, however, a heightened index of suspicion, especially given the
Väderprognoser är av stor betydelse för till exempel flygrutter, militära operationer och sjöfart. Flera organisationer tillhandahåller numera inte bara sina väderprognoser öppet, utan delar även med sig av sina prognosdata för nedladdning. Teknisk utveckling och ett större utbud av öppna data möjliggör användning av väder- och prognosdata för både privata och kommersiella ändamål. Egna programmerWeather forecasts are of great significance for instance in planning flight routes, military operations, and seafare. Many organizations today openly provide, not only their forecasts, but their raw data as well. Technological development and a greater availability of open data ensures that both weather- and forecast data can be used for both private and commercial purposes. However, customized ap
PURPOSE: Major hurdles in oXHTx are the delayed xenograft rejection, the early perioperative cardiac xenograft dysfunction (PCXD) and the pig heart overgrowth, which were solved in this study with a costimulation blockade, a new non-ischemic cold preservation and a growth inhibition by anti-proliferative drugs. Aim was to achieve a 90-days-survival of minimal 60% (6 of 10 baboons) in this life-sup
Introduction: Cognitive function is an important outcome measure in patients with brain tumor, providing information about the patient’s clinical situation, treatment effects and possible progressive disease. The aim of this longitudinal study was to evaluate effects of the currently used radiation and chemotherapy treatment on cognitive function and to investigate associations between cognitive f
The Circular Economy (CE) has gained global recognition as a way to enable sustainability improvements in production and consumption systems. Numerous circularity indicators (c-indicators) have been developed by academia and practitioners to be used at the company level as analytical tools to measure progress towards a more circular economy. Nevertheless, there is a lack of empirical evidence on t
This thesis examines the transport justice in Copenhagen for multimodal transport using cycling and the metro network, to answer the research question ‘How equitable and equal is the bicycle access to high-capacity public transport metro stations in Copenhagen, and how is transport justice distributed?’. This question is answered by combining an expert interview, field observations, and geographic
The maritime sector needs to reduce greenhouse gas emissions and improve the sustain ability of energy systems. Ammonia has attracted increasing attention as a potential carbon-free marine fuel. However, ammonia has low reactivity, a high ignition energy requirement, and a low flame propagation speed, which make stable combustion difficult. Diesel-ignited ammonia combustion is therefore a promisin
Air emissions are becoming a larger problem in today’s society and therefore the limits are getting stricter. This means that chemical-producing industries which create multiple byproducts, acting like air pollutants, requires to improve their emission limiting systems. Johnson Matthey Formox AB is a company who sells licenses and catalysts for formaldehyde production by the FORMOXTM process. Prod
We present the detection and characterisation of the TOI-1438 multi-planet system discovered by the Transiting Exoplanet Survey Satellite (TESS). To confirm the planetary nature of the candidates and determine their masses, we collected a series of followup observations including high-spectral resolution observations with HARPS-N and HIRES over a period of 5 years. Our combined modelling shows tha
