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Background: Historically, endocrine therapy was used in a range of scenarios in patients with rising PSA, both as a treatment for locally advanced non-metastatic prostate cancer and PSA recurrence following curative intended therapy. In the present study the objective was to investigate if chemotherapy added to endocrine therapy could improve progression-free survival (PFS). Materials and Methods:

Background: With improving survival in ovarian cancer, second primary cancers (SPCs) and their etiological foundations are becoming an issue. The ways in which family history may influence the occurrence of SPCs and the related mortality are not well known. Methods: Based on the Swedish Family-Cancer Database, we identified 11,300 ovarian cancer patients and followed them for diagnoses of SPCs unt

Background: Metastatic castration resistant prostate cancer (mCRPC) is a bone dominant lethal disease. Progression in bone scan of mCRPC disease is assessed with the Prostate Cancer Working Group (PCWG) two and three criteria, which relies on the appearance of two or more new lesions. There is an unmet need for a quantitative assessment that can build on the current progression criteria. This thes

Disease prevalence in wildlife is governed by epidemiological parameters (infection and recovery rates) and response to infection, both of which vary within and among individual hosts. Studies quantifying these individual-scale parameters and documenting their source of variation in wild hosts are fundamental for predicting disease dynamics. Such studies do not exist for the influenza A virus (IAV

The photo-electro catalysis has emerged as efficient and sustainable degradation method for antibiotics, where metal oxide anode plays a critical role. Exploring novel preparation method for anodes catalysis to achieve larger active sites and diverse oxidants production can directly enhance the degradation performance. Therefore, in this work, a new urea precipitation method for anode formation wa

Massive expansion of erythroid progenitor cells is essential for surviving anemic stress. Research towards understanding this critical process, referred to as stress-erythropoiesis, has been hampered due to the lack of specific marker-combinations enabling analysis of the distinct stress-progenitor cells capable of providing radioprotection and enhanced red blood cell production. Here we present a

Understanding the critical soil moisture (SM) threshold (θcrit) of plant water stress and land surface energy partitioning is a basis to evaluate drought impacts and improve models for predicting future ecosystem condition and climate. Quantifying the θcrit across biomes and climates is challenging because observations of surface energy fluxes and SM remain sparse. Here, we used the latest databas

The history of spinal cord injuries starts with the ancient Egyptian medical papyrus known as the Edwin Smith Surgical Papyrus. The papyrus written about 2500 B.C.by the physician and architect of the Sakkara pyramids Imhotep, describes "crushed vertebra in his neck" as well as symptoms of neurological deterioration. An ailment not to be treated was the massage to the patients at that time. This f

Environmentally safe disposal of urban waste is a global concern that recently gained a new dimension through the lens of Environmental Justice, with a growing literature showing correlation between the placement of waste facilities and disadvantaged groups in society. This thesis seeks to verify whether landfills in the city of São Paulo are located in regions where socially and economically vuln

Background: Knowledge sharing within an organization is one of the main focuses of the knowledge management research field. In today’s globally dispersed business units, and multinational corporations (MNCs), information and communication technology (ICT) tools play an essential role in facilitating knowledge sharing. Previous research has argued the vital role informal contexts as well as physica

Sedan generationer tillbaka har kärnkraft och kärnvapen använts för deras oöverträffade förmåga att frigöra energi. Detta har satt sitt spår på bland annat havsmiljöer världen över, i vilka föroreningar av mänskligt framställda radioaktiva ämnen kan hittas. Lyckligtvis är nivåerna av radioaktiva ämnen i haven idag inte så höga att de utgör någon direkt fara för varken människor eller djurliv, men Introduction: Decades of nuclear activities have polluted marine environments with transuranium actinides. Background: Brown algae have frequently been used as marine bioindicators of radioactivity, but current literature describing the sequential separation and determination of Pu and Am from brown algae matrices is sparse, and does not make use of recent extraction chromatographic resins such

Under de senaste fem åren har olika ekonomiska faktorer som påverkar bostadssituationen i Sverige ökat avsevärt, med skyhöga elpriser, bostadräntor och en hög inflation bl.a. Läget har gjort det omöjligt för främst unga, äldre eller människor i utanförskap att införskaffa en egen bostad. Samtidigt är landet ett av de länder som har flest ensamboenden i sina städer, vilket är en stor orsak till psyOver the past five years, various economic factors affecting the housing situation in Sweden have significantly increased, including skyrocketing electricity prices, housing interest rates, and high inflation, among others. This situation has made it impossible for primarily young people, the elderly, or individuals facing social exclusion to acquire their own homes. At the same time, the country

Klimatförändringar är antagligen en av de största utmaningarna i modern tid, där förhöjda halter av växthusgaser i atmosfären har förödande konsekvenser på jordens livsuppehållande system. Koldioxid är ansedd som den mest utsläppta växthusgasen, vilket har lett till ett ökat intresse för koldioxidinfångning. Ett sätt för att minska de förhöjda halterna av koldioxid i atmosfären är genom koldioxidiWith climate change being one of the greatest challenges of our time, interest in carbon dioxide removal and mitigation has increased, as a way of minimizing emissions. As a result, carbon capture has become a key focus in the industry. One of the most common chemical absorption techniques is carbon capture using hot potassium carbonate (HPC). This process operates at an elevated absorber pressure

PFAS are a group of persistent and harmful chemicals that are widely used in both industrial applications and consumer products. PFAS are commonly detected in the environment and pose health concerns. Adsorption by GAC is considered an effective treatment method for removing PFAS from water. After a certain period of operation, GAC requires high-temperature incineration as disposal method. Another

Popular Abstract in Swedish Neuroblastom är den vanligaste solida tumören, utanför hjärnan, hos små barn och finns nästan inte alls hos vuxna. Varje år insjuknar mellan femton och tjugo barn i Sverige, de flesta före två års ålder. Överlevnaden har ökat de senaste tjugo åren men är fortfarande på låga nivåer för de mer aggressiva formerna. Neuroblastom uppstår i det sympatiska nervsystemet. DärförIn this thesis, the main focus has been on the childhood cancer neuroblastoma, one of the most common and lethal childhood tumours. Neuroblastoma has througout the years continued to be a clinical and biological enigma. Our first focus was on one of the most important biological risk factors in neuroblastoma -- amplification of the oncogene MYCN in the tumour cells. Because amplified MYCN typical

55 m.ö.h. på Balsbergets södra sluttning finner man en av Sydsveriges största grottor, Balsbergsgrottan. Ungefär 250 meter vindlande gångar grenar sig ut från två större salar. Grottan har en rik historia, både ur ett geologiskt och ett funktionalistiskt perspektiv. De sedimentära bergarterna som bildades för 100 miljoner års sedan lade grunden till, att det efter förra istiden kunde bildas en gro55 meters above sea level on the southern slope of Balsberget you can find one of southern Sweden's largest caves, the Balsberg cave. Approximately 250 meters winding paths branch out from two large halls. The cave has a rich history, both from a geological and a functional perspective. The sedimentary rocks, formed 100 million years ago, laid the foundations for the advent of a cave here afte

This Master's Thesis examines the possibility of developing a software tool for optimizing offshore wind power plant layouts in regards to wake effects. The study was conducted with the purpose of making development and operation of offshore wind power plants more efficient and cost effective. The tool, named OptiWind, was developed in Python and employs several imported packages for mathemati

Extrema klimathändelser, såsom betydande översvämningar, utgör en risk för naturkatastrofer. På grund av klimatförändringarnas effekter förväntas södra Sverige få fler betydande regnväder som kan orsaka översvämningar i allt högre grad med mängden utsläpp. I denna studie undersöks dagens och framtidens översvämningsrisk i ett litet område i denna region, inom Kävlinges avrinningsområde. I det framExtreme climate events, such as significant flooding, pose a natural disaster risk. Due to climate change effects, the southern region of Sweden is anticipated to receive more significant rainstorms that could cause flooding increasingly with the quantity of emissions. This study examines the present-day and future climate’s flooding risk in a small area in this region, within the Kävlinge Watersh

During an archaeological excavation in Uppåkra 2010 I found a so-called “guldgubbe”(goldfoilfigure). This find really caught my attention and especially so because their functions are still debated. This master thesis is about the meaning and use of this, more appropriately called, goldfoilfigure. Many attempts to solve the questions surrounding the functions of the figures have been made during t

Geologiska institutionens forskningsstrategi 2014–2020 Geologiska institutionens forskningsstrategi 2014–2020 I forskningsutvärderingen RQ08 fick Geologiska institutionens forskargrupper omdömena ”very strong” och ”outstanding” av utvärderingspanelen. Den största och mest betydelsefulla förändringen av vår interna forskningsmiljö sedan dess är att toppforskare från andra lärosäten har rekryterats

https://www.geologi.lu.se/sites/geologi.lu.se/files/geologi_lbb_150303_sve_ac.pdf - 2026-05-30