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Apolipoprotein M (apoM) is a novel apolipoprotein presented mostly in high-density lipoprotein (HDL) in human plasma, and is exclusively expressed in liver and in kidney. The pathophysiological function of apoM has not yet been elucidated. Apolipoprotein B (apoB), the characteristic apolipoprotein of low-density lipoprotein (LDL), is like apoM, a very hydrophobic protein, and thereafter they both
Sweden is the only Scandinavian country that uses closed treatment institutions based on coercive measures within the child welfare system, on a large scale, for the education and treatment of young criminal offenders and drug users. In Sweden there are in 2002 some 30 “homes for specialized supervision” of varying sizes and degrees of specialization – all run by a national board of institutional
The presented thesis work is concerned with the study of molecular dynamics using liquid nuclear magnetic resonance (NMR) spectroscopy. Spin relaxation dispersion experiments in the rotating frame (R1ρ) are employed to provide a detailed, atomic-resolution view of protein dynamics. Comprehensive investigations of 15N backbone and 13C methyl side-chain confor
Popular Abstract in Swedish Levande organismer, inklusive människor, har en 14C/12C-kvot som återspeglar miljön. När materialet dör slutar kroppen att fylla på 14C och kroppens 14C börjar sönderfalla till 14N. Detta gav upphov till den klassiska 14C-dateringsmetoden, vilken utvecklades av professor W.F. Libby, 1949 och gav honom Nobelpriset i kemi 1960. 14C-datering används huvudsakligen inom arkeThe testing of nuclear weapons in the atmosphere, in the middle of the 20'h century, resulted in a bomb-pulse excess of atmospheric 14C. A bomb-pulse dating method was thus developed. The latter is a method to determine the time of formation of formerly living modern (i.e. living after 1955) material , based on the 14C/ 12C ratio in it. The objective of this work was to evaluate the factors that c
Apelin, a recently discovered peptide with wide tissue distribution, regulates feeding behavior, improves glucose utilization, and inhibits insulin secretion. We examined whether apelin is expressed in human islets, as well as in normal and type 2 diabetic (T2D) animal islets. Further, we studied islet apelin regulation and the effect of apelin on insulin secretion. Apelin expression and regulatio
Infants with post-tricuspid valve shunts (PTS) may benefit from interatrial communication (IAC). The effect of IAC on left ventricular (LV) performance in these patients was studied. IAC was documented prospectively in 55 patients with PTS. Clinical status, echocardiographic dimensions of LV, mitral inflow Doppler, tissue Doppler velocities and time intervals were measured. Creatinine kinase (CK),
Den biologiska mångfalden fortsätter att minska trots att det såväl nationellt som internationellt finns en målsättning om att förlusten av den biologiska mångfalden ska hejdas. Idag anses en av de största miljöpolitiska utmaningarna vara att stoppa utarmningen av biologisk mångfald. Skogen utgör livsmiljö för hälften av alla landlevande arter i Sverige och ett hållbart skogsbruk är således livsavBiodiversity is in decline despite international and national goals of preventing this development. Preserving biodiversity is one of today’s greatest environmental policy challenges. Currently, half of all land living species in Sweden live in the forest, therefore a sustainable forestry industry is vital to ensure biodiversity. In fact, half of all red-listed species live in the forest. One of t
Enligt Newsecs rapport från 2016 söker företag idag kontor som har effektiv kontorsyta med stor flexibilitet vad det gäller både area och hyresavtal. Deras analys är att sådana kontor kommer fortsätta att efterfrågas. Vad som menas med flexibla hyresavtal är inget som är självklart i branschen men i detta examensarbete innebär sådana hyresavtal kortare hyrestider och mindre ytor för varje aktör soAccording to Newsec's report from 2016 companies are looking for offices that have efficient office space with great flexibility in terms of both area and lease. Their analysis is that such offices will continue to be demanded. What is meant by flexible real estate leases is nothing that is obvious in the industry but in this paper such leases mean less lease times and less space for each part
Hållbarhetsfrågor tar stort fokus i dagens debatter, personliga livsstilar samt företagens marknadsföring och affärsmodeller. Miljöarbetet i byggsektorn drivs framåt via bland annat miljöcertifieringssystem. Framförallt nybyggnation präglas idag starkt av skärpta miljölagkrav och miljöcertifieringar tillämpas här i stor utsträckning. Vikten av miljöarbetet med redan befintliga byggnader hamnar oftThe subject sustainability is taking a great amount of spotlight in most debates of modern society. This time the focus is on business models and marketing as well as the influences that sustainable certification systems have within the building sector. Especially when constructing new buildings, the new and stricter sustainability laws and certifications are setting the foundations of a new era.
A ubiquitous and accurate positioning system for mobile devices is of great importance both to business and research due to the large number of applications and services it enables. In most outdoor environments this problem was solved by the introduction of the Global Positioning System (GPS). In indoor or suburban areas however, the GPS signals are often too weak to enable a reliable position est
Populärvetenskaplig sammanfattning: Supernovor och andra galaktiska system skickar ut mängder av atomkärnor med nära ljusets hastighet, så kallad kosmisk strålning. Eftersom supernovor framförallt finns i spiralarmarna i vår galax och jorden över långa tidsperioder rör sig relativt spiralarmarna så har det föreslagits att kosmisk strålning inte varit konstant under jordens historia. Vidare har visIt has been suggested that the cosmic ray flux varies as Earth moves relative to the spiral arms in the galaxy. However, no satisfying record over the cosmic ray flux over long time scales has been presented. This work aims to investigate the possibility to use cosmic ray tracks in silicate mineral inclusions in sediment-dispersed extraterrestrial chromite (SEC) grains as such a record. Chromite i
Den termiska klimatupplevelsen påverkas mest av lufttemperaturen som är enkel att mäta med en vanlig termometer, men för att ta reda på hur temperaturen i ett rum upplevs räcker det inte med att enbart undersöka lufttemperaturen. Även om lufttemperaturen ligger på en komfortabel nivå så kan en kall yta i närheten få personen att känna att det är kyligt i rummet och på motsvarande sätt kan varma ytThe thermal climate experience is most affected by air temperature that is easy to measure with a standard thermometer, but to find out how the temperature in a room is felt it is not enough to merely examine the air temperature. Even if the air temperature is at a comforta-ble level, then a cold surface near get the person to feel that it is chilly in the room and cor-respondingly the hot surface
When technology meets cell biology Lysosomes are small bags present in our cells that are filled with destructive molecules, normally needed for removing cell garbage. In some cases, these bags rupture and their contents leak into the interior of the cell leading to cell death. This can contribute to many diseases, such as Alzheimer’s disease. However, rupturing lysosomes intentionally, can also
Sveriges elsystem står inför en rad kommande utmaningar. En lovande lösning till många av dessa är efterfrågeflexibilitet. Men vad är byggnaders möjligheter och begränsningar att vara flexibla i sin elanvändning? Förutsättningarna för elförsörjningen i Sverige förändras i takt med att kärnkraften gradvis fasas ut och ersätts med väderberoende elproduktion i form av vind- och solkraft. Detta sker Sweden is heading towards an energy system with less nuclear power and more intermittent energy sources. Together with the coming electrification of the transport and industry sector, this challenges the future stability of the Swedish power system. However, a part of the solution could be that consumption of electricity temporarily is adjusted to facilitate the operation of the power system, reco
Today’s modern societies are becoming increasingly dependent on the vital societal functions that technical critical infrastructures provide, for example availability of electricity, tap water and internet connectivity. Hence, it is of essence that these infrastructures are resilient to interruptions. The purpose of this thesis is to investigate and contrast resilience levels of different types of
Idiopatisk normaltryckshydrocephalus (iNPH) är en neurologisk sjukdom som påverkar hjärnans vätskecirkulation och kan leda till symtom som gång- och balanssvårigheter, kognitiv nedsättning och urininkontinens. Sjukdomen drabbar omkring 1.5 % av 70-åringar, och prevalensen ökar med åldern. Det är en svårdiagnostiserad sjukdom där hjärnvätska (CSF) ansamlas i hjärnans hålrum, vilket påverkar hjärnanIntroduction: Idiopathic normal pressure hydrocephalus (iNPH) is a treatable but largely underdiagnosed neurological condition affecting the elderly population. It is characterised by gait and cognitive impairment, as well as urinary incontinence. For the most part, it is diagnosed via imaging and clinical assessments. Abnormalities in cerebrospinal (CSF) flow in the cerebral aqueduct have been li
BackgroundShock is a condition with high mortality even with early intervention and treatment. Usual care for shock and hypotension in the Emergency Department (ED) is intravenous fluid resuscitation which can lead to fluid overload and other complications. When fluid therapy fails or risk of complications are high, the next treatment step is the use of vasopressors for stabilisation. Noradrenalin
Over the last decade, the interest in research on extraterrestrial planets has expanded dramatically. With the number of confirmed exoplanets having increased tenfold over the last ten years, we now know that many different types of exoplanets exist. Modern telescopes, both ground- and space-based, like the Very Large Telescope (VLT) or the James Webb Space Telescope (JWST) will drive forward the
