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OBJECTIVE: In light of reports of de novo LN during belimumab (BLM) treatment, we sought to determine its frequency and contributing or protective factors in a real-life setting. METHODS: Patients with SLE who received BLM between 2011 and 2017 at five European academic practices were enrolled (n = 95) and followed longitudinally for a median time of 13.1 months [interquartile range (IQR): 6.0-34.
Screening for atrial fibrillation (AF) with a handheld device for recording the ECG is becoming increasingly popular. The poorer signal quality of such ECGs may lead to false detection of AF, often caused by transient noise. Consequently, the need for expert review in AF screening can become extensive. A convolutional neural network (CNN) is proposed for transient noise identification in AF detect
Alliances are volatile key components of many corporations' competitive strategies. They offer fast and flexible means of achieving market access, scale economies, and competence development. However, strategic alliances can encounter difficulties that often lead to disappointing performance. The authors suggest that the way partners manage the collective learning process plays a central role in t
As the proverbial noose tightens around humanity’s resource spending, research is focused on utilizing materials to their fullest potential. Nanotechnology is the ultimate way to economize by splitting objects into smaller parts and dispersing the material properties over greater surface to volume ratios. Emerging quantum effects at the nanoscale present unique tweaking opportunities in applicatio
Mantle cell lymphoma (MCL) is a B-cell malignancy currently considered incurable. Although some patients obtain prolonged remission after first-line chemoimmunotherapy, many will need several treatment lines. Here, we present a nationwide assessment of treatment strategies, time to progression and survival in MCL. All patients diagnosed with MCL 2006-2018 were identified in the Swedish Lymphoma Re
In 2009, the BergaåsenWater Supply Scheme was put into operation to ensure the future drinking water supply of two municipalities in southern Sweden. Bergaåsen replaced two vulnerable water treatment plants. It was implemented in an environment that was characterized by sensitive recipients and limited access to water. This article aims to analyze how strategies were developed to meet sustainabili
Background: Neurofibrillary tangle pathology is thought to drive neurodegeneration in beta-amyloid positive (A+) cognitively normal (CN) individuals, i.e., preclinical Alzheimer’s disease (AD).However, in beta-amyloid negative (A-) CN, the contribution of tau pathology [primary age-related tauopathy (PART)] to neurodegeneration remains uncertain. We investigate the correlation between tau burden m
Introduction: Drawing upon the framework of life course epidemiology, this study aligns with research on the mental health consequences of significant social transitions during early adulthood. The focus is on the variation in initial labour market attachment and the development of depressiveness, assuming that a firm attachment is associated with decreasing depressiveness. Methods: The baseline i
BACKGROUND AND PURPOSE: The treatment landscape for patients with advanced non-small cell lung cancer (NSCLC) has evolved significantly since the introduction of immunotherapies. We here describe PD-L1 testing rates, treatment patterns, and real-world outcomes for PD-(L)1 inhibitors in Sweden. MATERIALS AND METHODS: Data were obtained from the Swedish National Lung Cancer Registry for patients wit
The structural transformation toward the knowledge economy is often credited with increasing polarization and precarization of the low end of the labor market. Little is known, however, about the geography of low-income work since the literature has largely ignored sub-national variation. This article explores how the knowledge economy as the main driver of the transformation has affected the conc
IntroductionBeta-lactam antibiotics are essential in the treatment of Gram-negative bloodstream infections. The effect of beta-lactam antibiotics depends on the time of unbound antibiotic concentration above the minimal inhibitory concentration (MIC). An antibiotic concentration above MIC during the whole dosing interval (100% ƒT > MIC) has been suggested as a target for severe infections. The aim
An additional upsurge in bacterial STIs has been observed in Sweden following HIV pre-exposure prophylaxis (PrEP) implementation. From a prevention perspective, it is of relevance to optimize testing strategies within PrEP programmes to identify those most at risk. An open retrospective longitudinal observational cohort study was performed at three STI clinics in Uppsala, Gothenburg, and Malmö. A
Purpose: The aim of this study was to evaluate risk factors for postoperative pain and nausea after open repair for primary ventral hernias. Method: A population-based registry study was conducted based on data assembled from the Swedish national ventral hernia repair register between January 2016 and December 2021and cross-matched with the Swedish perioperative register. Results: Altogether 2064
Boendet har en stark koppling till äldres livskvalitet. Utformningen av äldres boendemiljö är viktig då de spenderar mycket tid i och i nära anslutning till boendet. Boendemiljön påverkar hur trygg den boende känner sig där exempelvis hala golv eller dålig belysning kan skapa en känsla av otrygghet. Sveriges befolkning ökar och antalet invånare över 65 väntas öka från 1,9 miljoner 2014 till 3 milThe living environment has a strong connection with elderly's quality of life. The design of the elderly housing environment is important as they spend a lot of time in and near their home. The housing environment affects how safe the residents feel, for example slippery floors or poor lighting can create an insecurity. Sweden's population is increasing and the population of those over 65
This thesis investigates to what extent Swedish students of Japanese can understand wasei-eigo, as well as their thoughts and attitudes toward it. It further investigates if some word categories are more incomprehensible than others and what aspects can determine their comprehension. The survey consisted of a questionnaire with 30 words, divided into 4 different categories, which the participants
The Sahel lies in the semi-arid zone of North Africa between the Sahara Desert to the north and the savannas and rainforest to the south. In the Sahel, the variability of vegetation growth is predominately controlled by moisture reception in the concurrent rainy season. The inter-annual variability of normalized difference vegetation index (NDVI) during the rainy season (April to August) can be ex
The HIE-ISOLDE post accelerator at CERN has recently come online, en- abling the use of radioactive ion beams with energies of up to 10 MeV/u. An active target gaseous detector is under development for use in some of the experiments. The first investigation of the electron amplification stage with gas electron multipliers has been performed. To this end, a small prototype GEM detector was built an
Businesses today need to recognize that they have to be fast at realizing and exploiting new competitive advantages before the opportunity is lost. Instead of the traditional focus on price and quality, there is a shift towards the delivery of value to customers. This is strongly connected to the reduction of downtime of production and high reliability. Here the spare parts supply chain plays an i
Popular Abstract in Swedish Blåsexstrofi är en ovanlig och mångfasetterad missbildning. I hela Sverige föds cirka tre barn om året med blåsexstrofi. Bukvägg och urinblåsa är öppna nedanför naveln, så att man ser blåsans insida samt rinnande urin. Flickorna har en delad clitoris, framflyttad och trång slidöppning samt framflyttad ändtarmsöppning. Pojkarna har en kort, öppen penis, som ligger uppfälBladder exstrophy is a complex malformation seen in 1/30 000. Most children are subject to repeated operations, including pelvic osteotomy, genital and bladder neck reconstruction and sometimes bladder augmentation or a urinary reservoir, to achieve continence and a normal genital function. A retrospective study of all Swedish children born 1970-89 showed a low continence rate, 17% , and a high r
