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Background: It has been suggested that changes in prostate-specific antigen (PSA) over time (ie, PSA velocity [PSAV]) aid prostate cancer detection. Some guidelines do incorporate PSAV cut points as an indication for biopsy. Objective: To evaluate whether PSAV enhances prediction of biopsy outcome in a large, representative, population-based cohort. Design, setting, and participants: There were 27

Knowledge of the forest biomass and its change in time is crucial to understanding the carbon cycle and its interactions with climate change. LiDAR (Light Detection and Ranging) technology, in this respect, has proven to be a valuable tool, providing reliable estimates of aboveground biomass (AGB). The overall goal of this study was to develop a method for assessing AGB using a synergy of low poin

In this paper, we address distributed convergence to fair allocations of CPU resources for time-sensitive applications. We propose a novel resource management framework where a centralized objective for fair allocations is decomposed into a pair of performance-driven recursive processes for updating: (a) the allocation of computing bandwidth to the applications (resource adaptation), executed by t

Popular Abstract in Swedish Åldrandet har traditionellt förknippats med en reduktion av emotionella reaktioner. Denna syn har nu börjat ifrågasättas, trots att de flesta tidigare studier visat en åldersrelaterad minskning av psykofysiologiska reaktioner på affektiva stimuli. Det första syftet med denna avhandling var att undersöka effekter av åldrande på subjektivt upplevande av och psykofysiologiIt has long been thought that aging is accompanied by an emotional flattening. Although a different view has started to emerge recently, studies investigating psychophysiological responses in reaction to affective stimuli so far have reported an age-related reduction of the affective response. One of the main goals of this thesis was to revisit this issue by examining subjective reports, phasic he

This report contains papers presented at a Research Seminar , or rather "workshop", organised by our Department. It is the third in a series. The previous seminars were held in 1993 and 19961• The seminar is "Nordic", by which is meant that the speakers came from the Scandinavian countries -Demnark, Norway, Sweden- and Finland. Certainly there are other Nordic countries in which frost is a real pr

BACKGROUND: Proper treatment of lymph node-negative breast cancer depends on an accurate prognosis. To improve prognostic models for this disease, we evaluated whether an immunohistochemical marker for proliferating cells, Ki-S2 (a monoclonal antibody that binds to a 100-kd nuclear protein expressed in S, G2, and M phases of the cell cycle), is an accurate indicator of prognosis.METHODS: We studie

Popular Abstract in Swedish Att balansera. Cancer från ett primärvårdsperspektiv. Diagnostik, posttraumatisk stress och vård vid livets slut Denna avhandling belyser cancer från en utgångspunkt som kanske inte handlar om vad man först kommer att tänka på när man hör ordet cancerforskning. Det handlar inte om att “lösa cancerns gåta” eller att hitta nya metoder för behandling eller diagnos. UtgångThis thesis explores cancer from a primary care perspective covering three areas: diagnosis, posttraumatic stress disorder (PTSD), and end-of-life care. We analyzed patient records of every child diagnosed with a malignancy in a defined area. During 12 years 68 children were diagnosed (incidence 14/100,000). For 68% the diagnosis was initiated in primary care. There were 25 children with leukemia

One of the challenges that must be overcome to realize the practical benefits of ad hoc networks is quality of service (QoS). However, the IEEE 802.11 standard, which undeniably is the most widespread wireless technology of choice for WLANs and ad hoc networks, does not address this issue. In order to support applications with QoS requirements the upcoming IEEE 802.11e standard enhances the origin

Background: When the same dose of iodine is given to all patients when performing abdominal computed tomography (CT) there may be a wide inter-individual variation in contrast medium (CM) enhancement of the liver. Purpose: To evaluate if any of the measures body height (BH), body mass index (BMI), lean body mass (LBM), ideal body weight (IBW), and body surface area (BSA) correlated better than bod

Background Previous Studies have shown increased familial risk for chronic lymphocytic leukemia. In the most comprehensive study to date, we evaluated risk of chronic lymphocytic leukemia and lymphoproliferative disorders among First-degree relatives of chronic lymphocytic leukemia cases compared to first-degree relatives of controls. Design and Methods Population-based registry data from Sweden w

Anomaly detection is emerging as a necessary component as wireless networks gain popularity. Anomaly detection has been addressed broadly in wired networks and powerful methods have been developed for correct detection of a variety of known attacks and other anomalies. In this paper, we propose a real-time anomaly detection and identification scheme for wireless mesh networks (WMN) using component

The polymeric immunoglobulin receptor (pIgR) is a key component of the mucosal immune system that mediates epithelial transcytosis of immunoglobulins. High pIgR expression has been reported to correlate with a less aggressive tumour phenotype and an improved prognosis in several human cancer types. Here, we examined the expression and prognostic significance of pIgR in pancreatic and periampullary

Background: The metabolism of amyloid precursor protein (APP) and beta-amyloid (A beta) is widely studied in Alzheimer's disease, where A beta deposition and plaque development are essential components of the pathogenesis. However, the physiological role of amyloid in the adult nervous system remains largely unknown. We have previously found altered cerebral amyloid metabolism in other neuroinflam

Forests are important from many perspectives. Forestry delivers products such as timber, fiber and fuel; forests are also important for recreational activities as well as for the global carbon balance. Consequently, it is important to develop methods that enable efficient monitoring of disturbances, such as insect attacks, over vast forested areas. These methods can be based on remote sensing, sin

OBJECTIVE-To evaluate the significance of GAD antibodies (GADAs) and family history for type 1 diabetes (FHT1) or type 2 diabetes (FHT2) in nondiabetic subjects. RESEARCH DESIGN AND METHODS-GADAs were analyzed in 4,976 nondiabetic relatives of type 2 diabetic patients or control subjects from Finland. Altogether, 289 (5.9%) were GADA(+)-a total of 253 GADA(+) and 2,511 GADA(-) subjects participate

Climate warming in the Swedish sub-Arctic since 2000 has reached a level at which statistical analysis shows for the first time that current warming has exceeded that in the late 1930' s and early 1940' s, and has significantly crossed the 0 degrees C mean annual temperature threshold which causes many cryospheric and ecological impacts. The accelerating temperature increase trend has driven simil

BACKGROUND Men and women with type 2 long QT syndrome (LQT2) exhibit time-dependent differences in the risk for cardiac events. We hypothesized that data regarding the location of the disease-causing mutation in the KCNH2 channel may affect gender-specific risk in LQT2. OBJECTIVE This study sought to risk-stratify LQT2 patients for life-threatening cardiac events based on clinical and genetic info

Purpose - In order to improve cooperation and collaboration between units, clinics and departments, many health care organizations (HCOs) have introduced process orientation. Several studies indicate problems in realizing these ambitions. The purpose of this paper is to explain and understand the success and failure of process orientation in HCOs. Design/methodology/approach - The authors conducte