Filtyp
Active vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], plays a pivotal role in calcium homeostasis and bone metabolism. Circulating levels of 1,25(OH)(2)D(3) are thought to be dependent mainly on the activity of the renal cytochrome P450 enzyme 25-hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase), which is potently induced by PTH. However, 1alpha-hydroxylase activity or expressi
Means–ends decoupling, the institutionally induced implementation of ineffective practices, has become increasingly common. Extant theory suggests that means–ends decoupling has real consequences, which makes it unstable and difficult for organizations to sustain. Yet little is known of how, and with what outcomes, firms organize such means–ends decoupling. We examine organizing via multiple quali
Domain-specific languages are used in numerous problem domains, e.g. database handling, robot programming and numerical calculations. The main advantage of using such languages is the ease with which a problem within the domain can be expressed in the language. The resulting programs are easier to debug and maintain, and consist of higher quality code since the language constructs are close to the
To complete a new Swedish railway line in a much shorter timeframe than today, alter natives to the traditional methods need to be explored. One option is the use of prefabricated concrete slabs elevated on piers, analogous to the concept used in China for building new railways in record time (He et al., 2017). The method has the advantage of directly tackling the barrier effects exhibited by trad
Background and Aims: In temperate forests, fungi are the main actors in leaf litter decomposition. Still, we have minimal knowledge of their influence on changes in leaf litter chemistry. Thus, we aimed to determine the main drivers behind leaf litter chemical transformation during decomposition. Methods: We monitored the development of fungal communities, extracellular enzyme activities, and litt
AIM: To describe sociodemographic disparities in temporal trends of incidence and age distributions of first registered osteoarthritis (OA) diagnosis in southern Sweden.METHODS: We identified all Skåne residents aged 35+ who had lived in the region at any point during the period 2006-2019 with no previous OA diagnosis (ICD-10 codes M15-M19) for 8 years prior to inclusion in the study (n = 849,061)
The remaining lifetime of concrete structures subjected to chloride-induced corrosion has been studied in many papers. However, few studies so far consider explicitly experiences from case studies, jointly several corrosion mechanisms and a system perspective. This paper introduces a methodology to evaluate the time-dependent system reliability for concrete bridges subjected to reinforcement corro
In Sweden, the governance of healthcare is decentralized, so PC is provided with regional or local differences in organization, level of competence, and recourses. Ongoing regional and national initiative to increase quality of pediatric palliative care in Sweden aligns with the international standard of pediatric palliative care as a care directed towards all children with life-threatening or lif
Phosphate plays a crucial role in biology because of the stability of the phosphate ester bond. To overcome this inherent stability, enzymes that catalyze phosphoryl transfer reactions achieve enormous rate accelerations to operate on biologically relevant time scales, and the mechanisms that underpin catalysis have been the subject of extensive debate. In an archetypal system, β-phosphoglucomutas
Environmental transmission electron microscopy (ETEM) can provide unique insights into nanocarbon oxidation processes through atomic resolution and real time imaging of materials at high temperatures in reactive atmospheres. However, the electron beam can also influence the reaction rates, and even alter the processes entirely, complicating the interpretation of the in situ observations. Many mech
It is a long-standing view that the main mechanism maintaining narrow migratory divides in passerines is the selection against intermediate and suboptimal migratory direction, but empirical proof of this is still lacking. We present novel results from a willow warbler migratory divide in central Sweden from where birds take the typical SW and SE as well as intermediate routes to winter quarters in
Background: Since its inception in 1980, the MOHL index (% patients who are male, have occupational, hand, or leg dermatitis, respectively) and its later evolutions until the presently used MOAHLFA(P) index (adding % patients with atopic dermatitis, face dermatitis, age 40+ years and positive reaction(s) to ≥ 1 baseline series allergen) have been intended to convey important demographic and clinic
The present study aims to investigate boiling heat transfer enhancement on coated surfaces, based on mechanistic models. An electrochemical deposition method was used to fabricate coatings on copper surfaces which enhance critical heat flux and heat transfer coefficient of deionized water by 35.5% and 40.1%, respectively, compared with a smooth surface. Bubble dynamics indicates that regardless of
The main purpose of this thesis is to present a Cultural-Historical Activity Theory (CHAT) based analysis of the activities conducted by and with visually impaired users supported by audio-haptic technology.This thesis covers several studies conducted in two projects. The studies evaluate the use of audio-haptic technologies to support and/or mediate the activities of people with visual impairment
Aims/hypothesis: Some studies find an increased risk of type 1 diabetes in children exposed to antibiotics. We investigated if exposure to antibiotics increases the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes. Methods: We used data from a Swedish case–control study (Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes [ESTRID]: LADA, n=597; type 2 diabetes
Bark beetle infestations pose a significant threat to forest ecosystems, necessitating timely intervention for effective management and conservation. This study focuses on an 8,100 km2 area in southern Sweden, heavily impacted by a bark beetle outbreak triggered by a severe drought in 2018. Using spectral indices derived from Sentinel-2 data, it explores the potential of a window-based approach fo
Following the Paris Agreement's climate targets and the modelling community's scenarios of how to reach them, carbon dioxide removal is gaining increasing importance in national climate policies. This is also the case in Denmark – considered by itself and others a climate frontrunner – where biochar is envisioned to cover 10% of the 2030 reduction goal. However, apart from research experiments and
The initial adsorption of MeCpPtMe 3 is investigated using synchrotron-based ambient pressure x-ray photoelectron spectroscopy (XPS). The experiments are done on a native oxide-covered Si substrate. In addition, a reaction with O 2 and the created Pt surface was investigated. Inspiration for the reaction studies was found from atomic layer deposition of metallic Pt, process that uses the same comp
The major histocompatibility complex (MHC) plays a critical role in the immune response against pathogens. Its high polymorphism is thought to be mainly the consequence of host-pathogen co-evolution, but elucidating the mechanism(s) driving MHC evolution remains challenging for natural populations. We investigated the diversity of MHC class II genes in a wild population of pied flycatchers Ficedul
The Andes mountains extend north–south in a latitudinal gradient of 8500 km. Because of the great climatic variety and the peculiar north–south orographic distribution, lakes are highly diverse, including different lake origins and contrasting morphometries. We reviewed >700 ecological studies on Andean lakes to identify the main threats to these freshwater systems. The most important threats are
