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BACKGROUND. The objective of this study was to identify prognostic factors for predicting survival in patients with advanced renal cell carcinoma (RCC) who had undergone an allogeneic stem cell transplantation after failure on immunotherapy. METHODS. The authors Studied 70 patients with advanced RCC Who underwent allogeneic transplantation with a fludarabine-based, reduced-intensity regimen. Ten p

Human malignant infantile osteopetrosis (arOP; MIM 259700) is a genetically heterogenous autosomal recessive disorder of bone metabolism, which, if untreated, has a fatal outcome. Our group, as well as others, have recently identified mutations in the ATP6i (TCIRG1) gene, encoding the a3 subunit of the vacuolar proton pump, which mediates the acidification of the bone/osteoclast interface, are res

The Bog Ecosystem Research Initiative (BERI) projectwas initiated to investigate, at five climaticallydifferent sites across Europe, the effects of elevatedCO2 and N deposition on the net exchange ofCO2 and CH4 between bogs and the atmosphere,and to study the effects of elevated CO2 and Ndeposition on the plant biodiversity of bogcommunities. A major challenge to investigate theeffects of elevated

Gliomas are the most common primary brain tumors and offer a poor prognosis in patients because of their infiltrative and treatment-resistant nature. The median survival time after diagnosis is approximately 11-12 months. There is a strong need for novel treatment modalities in targeting gliomas, and recent advances use neural progenitor cells as delivery systems for different therapeutic strategi

Introduced species are interesting systems for the study of contemporary evolution in new environments because of their spatial and temporal scales. For this study we had three aims: (i) to determine how genetic diversity and genetic differentiation of introduced populations of the house sparrow (Passer domesticus) in Brazil varies with range expansion, (ii) to determine how genetic diversity and

In northern Patagonia, macrolichens form species-rich and abundant epiphytic communities in southern beech forests. Five of the most abundant lichen species in the litter were selected in order to study mass loss rate and changes in mineral composition over time. The litter bag method was applied to the foliose lichens Pseudocyphellaria faveolata, Pseudocyphellaria flavicans, Nephroma antarcticum,

An easy and rapid hollow-fibre supported liquid membrane method (HFSLM) has been developed to extract and determinate the total concentration of four dinitrophenols in environmental water at ng L-1 level. This extraction method provides a high selectivity, short extraction time and very low cost for real samples. It is a three-phase system, aqueous-organic-aqueous, where the organic solvent is hel

BACKGROUND: Limited data exists of tracking and changes in accelerometer measured physical activity in children. METHODS: Physical activity was assessed by accelerometers for four days in 167 children (boys n=90, girls n=77), aged 9.8±0.6 years. Follow-up measurement was made 2.0±0.1 yrs later (range 1.9-2.1 yrs). General physical activity (GPA) was defined as mean count/minute. Minutes of inact

The gamma Y moth selects to migrate in stronger winds compared to songbirds, enabling fast transport to distant breeding sites, but a lower precision in orientation as the moth allows itself to be drifted by the winds. Photo: Ian Woiwod. In Focus: Chapman, J.R., Nilsson, C., Lim, K.S., Bäckman, J., Reynolds, D.R. & Alerstam, T. (2015) Adaptive strategies in nocturnally migrating insects and so

The Bayan Har Shan, a prominent upland area in the northeastern sector of the Tibetan Plateau, hosts an extensive glacial geological record. To reconstruct its palaeoglaciology we have determined Be-10 exposure ages based on 67 samples from boulders, surface pebbles, and sediment sections in conjunction with studies of the glacial geology (remote sensing and field studies) and numerical glacier mo

Injury to the peripheral nerves in the upper extremity results in changes in the nerve, and at multiple sites throughout the central nervous system (CNS). We studied the long-term effects of an injury to the median nerve in the forearm with a focus on changes in the CNS. Four patients with isolated injuries of the median nerve in their 20s were examined a mean of 14 years after the injury. Cortica

Understanding wood surface moisture variations is fundamental to the modelling of moisture content. Exposure to sunlight, fluctuating temperature and rain leads to superficial deterioration and reduced surface hydrophobicity. Here, the effect of weathering was studied through monitoring the surface and global moisture content of axially matched pre-weathered and planed sets of specimens exposed ou

I denna avhandling beskrivs processesen att implementera och optimisera metoder inom kvantitativ magnetresonansomografi (MRT) på en fältstyrka av 7 T. Metoderna är baserade på gradientekon med påtvingad transversell urfasning (spoiling) och applicerade på den mänskliga hjärnan i syfte att avbilda i huvudsak tre olika MR-parametrar: Den longitudinella relaxationstiden (T1), magnetization transfer sQuantitative MRI (qMRI) refers to the process of deriving maps of MR contrast parameters, such as relaxation times, from conventional images. If the qMRI maps have a high degree of precision and a low degree of bias, they can be compared longitudinally, across subjects, and (ideally) between measurement protocols and research sites. They also provide a more direct biophysical interpretation of the

Objective: Congenitally corrected and surgical atrial redirected transposition of the great arteries (TGA) represents states where the morphological right ventricle serves as a systemic ventricle (S-RV). The S-RV is prone to failure, but data on medical treatment on this problem is limited. The purpose of this study was to evaluate the survival in adults with S-RV, with or without heart failure tr

The text describes new methods elaborated for and used in the building archaeological assessment of a city block, studied first on site, then remotely by members of the Swedish Pompeii Project. Use of a digital platform, with collected wall observations and analysis, systematic photographic documentation of all standing structures, and 3D models, allowed discussion to proceed after the fieldwork c

Families often prefer home care to hospital care, and home-care services for ill children are increasing worldwide with limited knowledge of families’ needs during curative and palliative home care. The aim of this study was to elucidate family members’ lived experience when a sick child received home care from county-based primary healthcare services. A descriptive qualitative design was chosen a

In this paper we construct a hierarchical model for spatial compositional data which is used to reconstruct past land-cover compositions (in terms of coniferous forest, broadleaved forest, and unforested/open land) for five time periods during the past 6000 years over Europe. The model consists of a Gaussian Markov Random Field (GMRF) with Dirichlet observations. A block updated Markov chain Monte