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FoxP1 promotes midbrain identity in embryonic stem cell-derived dopamine neurons by regulating Pitx3

P>The robust generation of midbrain dopamine neurons from embryonic stem cells and patient-specific induced pluripotent stem cells is a prospective tool for the development of new drugs and cell based therapies, and investigations into the aetiology of Parkinson's disease. To achieve this, it is crucial to identify the fate-determining regulatory factors that influence dopamine cell fate decision

Writing Rights into Thailand's History with Photography

Photography is a recognized medium to spread information about atrocities and to raise awareness about human rights issues. Photography is also widely used by political actors and social move- ments to construct an image of themselves and their causes. The political potential of photography is closely connected to the role of the visual in the public. The language of photography is at the same tim

Bearing selection in ball-rolling dung beetles: is it constant?

Ball rolling in dung beetles is thought to have evolved as a means to escape intense inter- and intra-specific competition at the dung pile. Accordingly, dung beetles typically roll along a straight-line path away from the pile, this being the most effective escape strategy for transporting dung to a suitable burial site. In this study, we investigate how individual diurnal dung beetles, Scarabaeu

Experiments with service-oriented architectures for industrial robotic cells programming

Integration of equipment in industrial robot cells is to an increasing part involved with interfacing modern Ethernet technologies and low-cost mass produced devices, such as vision systems, laser cameras, force-torque sensors, soft-PLCs, digital pens, pocket-PCs, etc. This scenario enables integrators to offer powerful and smarter solutions, more adapted to small and medium enterprises (SMEs), ca

Relocating the owl of wisdom : Encyclopaedias in a life-historical perspective

Artikeln undersöker människors förhållningssätt till uppslagsverk och encyklopedier i ett livshistoriskt perspektiv under en period när encyklopedier har genomgått dramatiska förändringar. En frågelista som skickats till fasta så kallade meddelare knutna till Folklivsarkivet i Lund har använts som metod. Svaren har analyserats med hjälp av posthumanistisk teori. Analysen visar de sätt som tryckta Encyclopaedias are artefacts that both define and are defined by the culture in which they are produced and used. Encyclopaedias mirror the time of their creation, at the same time as understanding and use of encyclopaedias is tied to both time and space. From the 19th century until the present day encyclopaedias have changed from exclusive and costly Collections of books kept mainly in libraries

Distribution Channel Reengineering - Organisational Separation of Distribution and Sales Functions in the European Market

In this article, the concept of distribution channel re-engineering stands for a restructuring of distribution activities where the physical distribution and sales functions are organizationally separated from each other. The objective of the re-engineering process is primarily to reach dramatic improvements in operational efficiency. Our study indicates improvements in the distribution process in

Informed in and through difference: The perspectives of Johannesburg's suburban reservists and their role in the SAPS

Despite a fair amount of academic attention being afforded to the South African Police Service (SAPS), one actor within it has been constantly ignored. Considering reservists make in excess of 15% of the overall policing staff (albeit only as temporary staff) in Gauteng this gap is surprising. Reservists wear an identical uniform and carry out the same functions as permanent members but are not re

Late Quaternary landscape and vegetation diversity in a North European perspective

The rarefaction technique applied to fossil pollen sequences for analyzing palynological richness, interpreted as a signal of biological diversity of landscapes and vegetation, has been developed since 1988. Errors including population evenness and vegetation disturbance have been considered in this study. Information from two sites is discussed, one with a pollen diagram covering Late-Glacial (La

Substituent distribution and clouding behavior of hydroxypropyl methyl cellulose analyzed using enzymatic degradation

The distribution of substituents along the polymer backbone will have a strong influence on the properties of modified cellulose. Endoglucanases were used to degrade three different batches of hydroxypropyl methyl cellulose ( HPMC) derivatives with similar chemical properties. The phase separation of the HPMCs as a function of temperature, i.e., the clouding behavior, was analyzed prior to degrada

Solute transport and water content measurements in clay soils using time domain reflectometry

Clayey and saline soils have been shown to be problematic for time domain reflectometry (TDR) measurements. This study presents some of these problems and discusses solutions to them. Thirteen solute transport experiments were carried out in three undisturbed soil columns of swelling clay soil from Tunisia, labelled S1, S2, and S3 respectively. The columns were collected at three different physiog

Hospital readmissions among older people with intellectual disability in comparison with the general population

Background: Older people with intellectual disability have high multimorbidity and poor physical and mental health compared with the general population. Consequently, they have a greater need for health care. Hospital readmissions may be an indicator of the quality of health care. However, so far, only a few studies have investigated this outcome in populations of people with intellectual disabili

Services and disservices of ant communities in tropical cacao and coffee agroforestry systems

Tropical tree crops such as cacao and coffee are produced around the tropics in diverse, multistrata agroforests as well as monoculture plantations Box 16.1 and references therein). The smallholders cultivating these systems battle pests and diseases that differ regionally and change over time, but often take a significant part of their yield, and therefore their revenue. In these perennial system

α1-microglobulin protects against bleeding-induced oxidative damage in knee arthropathies

Knee injury increases the risk of developing knee osteoarthritis (OA). Recent evidence suggests involvement of oxidative stress induced by inflammation and bleeding in the joint. This study investigates the role in this process of α1-microglobulin (A1M), a plasma and tissue antioxidant protein with reducing function, and heme- and radical-binding properties. We studied matched knee synovial fluid

Time-dependent prognostic effects of recipient and donor age in adult heart transplantation

BACKGROUND: Recipient age and donor age are well-known prognostic factors in adult heart transplantation. However, the association between donor age and recipient age and their interaction and short- and long-term mortality is unknown. METHODS: We studied 64,354 heart transplants to adult recipients between 1988 and 2013 in the ISHLT Registry. Donor age and recipient age were analyzed as continuou

Water Services Sustainability: Institutional Arrangements and Shared Responsibilities

Poor water services in developing countries after national conflict as a result of institutional setups and devastating infrastructures. This study assesses how institutional arrangements have affected the poor water services in Somalia, through thematic analyses. The huge gap in the literature about Somalia highlights the significant need of such research works and the originality of this paper.

Clinical experience with a customized fenestrated endograft for juxtarenal abdominal aortic aneurysm repair

Despite the numerous stent-graft devices available, unsuitable anatomy is still the greatest exclusion criterion for endovascular abdominal aortic aneurysm (AAA) repair (EVAR). The present report describes an on-site preprocedural customization of a conventional Zenith stent-graft device just before the endovascular procedure that includes the creation of fenestrations and scallops as necessary fo

Organised Chaos: Water and Sanitation Systems in Housing Areas in Dar es Salaam, Tanzania

This thesis focuses on the provision and management of water supply and sanitation in housing areas in the City of Dar es Salaam. The main objective of the study is to contribute to knowledge and understanding of provision and management of urban water supply and sanitation in Tanzania in the context of sustainable urbanisation. A sectoral and single problem issue study approach was avoided and in

Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Adults Aged 20-64 Years in 1990-2013: Data from the Global Burden of Disease 2013 Study

Background: Recent evidence suggests that stroke is increasing as a cause of morbidity and mortality in younger adults, where it carries particular significance for working individuals. Accurate and up-to-date estimates of stroke burden are important for planning stroke prevention and management in younger adults. Objectives: This study aims to estimate prevalence, mortality and disability-adjuste

Recombinantly produced cellobiose dehydrogenase from Corynascus thermophilus for glucose biosensors and biofuel cells

Cellobiose dehydrogenase (CDH) is an emerging enzyme in the field of bioelectrocatalysis. Due to its flexible cytochrome domain, which acts as a built-in redox mediator, CDH is capable of direct electron transfer (DET) to electrode surfaces. This rare property is employed in mediatorless "third generation" biosensors. The ability of Corynascus thermophilus CDH to oxidize glucose under physiologica

Detection and Characterization of Fracture Zones in Bedrock - Possibilities and Limitations

In Norway, resistivity measurements have already been tested in marine environments in order to detect subsea fracture zones. However, most of these data have been processed without taking into account the special conditions the presence of seawater creates. More recent studies worldwide have also applied ERT in marine conditions, but under more favorable conditions nevertheless since they dealt w