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Analysis of Computational Algorithms for Linear Multistep Methods

Linear multistep methods (LMMs) constitute a class of time-stepping methods for the solution of initial value ODEs; the most well-known methods of this class are the Adams methods (AMs) and the backward differentiation formulae (BDFs). For the fixed stepsize LMMs there exists an extensive error and stability analysis; in practical computations, however, one always uses a variable stepsize. It is w

Spinal cord injury in zebrafish induced by near-infrared femtosecond laser pulses

BACKGROUND: The spinal cord is composed of a large number of cells that interact to allow the organism to function. To perform detail studies of cellular processes involved in spinal cord injury (SCI), one must use repeatable and specific methods to target and injure restricted areas of the spinal cord.NEW METHOD: We propose a robust method to induce SCI in zebrafish by laser light. With a 2-photo

SOX2 is a promising predictor of relapse and death in advanced stage high-grade serous ovarian cancer patients with residual disease after debulking surgery

The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be a marker of cancer stem cells. We investigated the role of SOX2 protein expression in women with high-grade serous ovarian cancer (HGSOC) to determine its potential prognostic and treatment predictive value. We constructed a tissue micr

Mellan åsikt och vittnesbörd : Amerika och Västerlandets arkaiska rötter

Popular Abstract in Swedish Frågan om Amerikas kulturella ställning i förhållande till den övriga världen är av central betydelse för all forskning som berör Amerikas och det moderna Europas historia. Det här förhållandet har blivit påtagligare under senare tid beroende av vårt samhälles senare "kris" med det s. k. "postmoderna" - och "globaliserade" - perspektivets genombrott. I avhandlingen presThe question of America’s cultural position in relation to the rest of the world is essential for all research connected to America and to the history of modern Europe. This situation has become obvious over the last years because of our societies’ latest “crisis”, with the consecration of the “post-modern” and “global” view of society, history and culture. The aim of the dissertation is to analys

Hyponatraemia despite isotonic maintenance fluid therapy : A time series intervention study

Objective: To examine the prevalence of dysnatraemias among children admitted for paediatric surgery before and after a change from hypotonic to isotonic intravenous maintenance fluid therapy. Design: Retrospective consecutive time series intervention study. Setting: Paediatric surgery ward at the Children's Hospital in Lund, during a 7-year period, 2010-2017. Patients: All children with a blood s

Towards clinical grating-interferometry mammography

Objectives: Grating-interferometry-based mammography (GIM) might facilitate breast cancer detection, as several research works have demonstrated in a pre-clinical setting, since it is able to provide attenuation, differential phase contrast, and scattering images simultaneously. In order to translate this technique to the clinics, it has to be adapted to cover a large field-of-view within a clinic

Important role of forest disturbances in the global biomass turnover and carbon sinks

Forest disturbances that lead to the replacement of whole tree stands are a cornerstone of forest dynamics, with drivers that include fire, windthrow, biotic outbreaks and harvest. The frequency of disturbances may change over the next century with impacts on the age, composition and biomass of forests. However, the disturbance return time, that is, the mean interval between disturbance events, re

A minimal model for the latitudinal diversity gradient suggests a dominant role for ecological limits

The latitudinal diversity gradient (LDG) is one of Earth’s most iconic biodiversity patterns and still one of the most debated. Explanations for the LDG are often categorized into three broad pathways in which the diversity gradient is created by (1) differential diversification rates, (2) differential carrying capacities (ecological limits), or (3) differential time to accumulate species across l

Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation : A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes

OBJECTIVE: Reparixin is an inhibitor of CXCR1/2 chemokine receptor shown to be an effective anti-inflammatory adjuvant in a pilot clinical trial in allotransplant recipients. RESEARCH DESIGN AND METHODS: A phase 3, multicenter, randomized, double-blind, parallel-assignment study (NCT01817959) was conducted in recipients of islet allotransplants randomized (2:1) to reparixin or placebo in addition

Ladyfest Sweden: a female cultural initiative

Ladyfest Sweden is a cultural festival which aims to create a cultural space of expression for women, thus the artists and the organizers are women. It is organized by three different groups in three different cities: Malmö, Stockholm and Göteborg. This thesis is focused on Ladyfest Malmö, all the field work being realized with this group. We tried to include this phenomenon in a global and a part

Massive star cluster formation and evolution in tidal dwarf galaxies

Context. The formation of globular clusters remains an open debate. Dwarf starburst galaxies are efficient at forming young massive clusters with similar masses as globular clusters and may hold the key to understanding their formation. Aims. We study star cluster formation in a tidal debris, including the vicinity of three tidal dwarf galaxies, in a massive gas-dominated collisional ring around N

The Gaia -ESO Survey : Lithium enrichment histories of the Galactic thick and thin disc

Lithium abundance in most of the warm metal-poor main sequence stars shows a constarnt plateau (A(Li) ~ 2.2 dex) and then the upper envelope of the lithium vs. metallicity distribution increases as we approach solar metallicity. Meteorites, which carry information about the chemical composition of the interstellar medium (ISM) at the solar system formation time, show a lithium abundance A(Li) ~ 3.

Global soil nitrous oxide emissions since the preindustrial era estimated by an ensemble of terrestrial biosphere models : Magnitude, attribution, and uncertainty

Our understanding and quantification of global soil nitrous oxide (N2O) emissions and the underlying processes remain largely uncertain. Here, we assessed the effects of multiple anthropogenic and natural factors, including nitrogen fertilizer (N) application, atmospheric N deposition, manure N application, land cover change, climate change, and rising atmospheric CO2 concentration, on global soil

Solute transport and water content measurements in clay soils using time domain reflectometry

Clayey and saline soils have been shown to be problematic for time domain reflectometry (TDR) measurements. This study presents some of these problems and discusses solutions to them. Thirteen solute transport experiments were carried out in three undisturbed soil columns of swelling clay soil from Tunisia, labelled S1, S2, and S3 respectively. The columns were collected at three different physiog

Optimal harmonic period assignment : complexity results and approximation algorithms

Harmonic periods have wide applicability in industrial real-time systems. Rate monotonic (RM) is able to schedule task sets with harmonic periods up to 100% utilization. Also, if there is no release jitter and execution time variation, RM and EDF generate the same schedule for each instance of a task. As a result, all instances of a task are interfered by the same amount of workload. This property

A Vascular Aging Index as Independent Predictor of Cardiovascular Events and Total Mortality in an Elderly Urban Population

The morphology and function of the arteries can be directly measured using different established methods. This prospective cohort study aimed to translate 2 of these, aortic pulse wave velocity (aPWV) and carotid intima–media thickness (cIMT), into a combined Vascular Aging Index (VAI) and then evaluate the predictive power of aPWV, cIMT, and VAI. Patients (n = 2718) were included from the cardiov

Experiences of partners of intensive care survivors and their need for support after intensive care

Background: When a relative with a critical illness is admitted to an intensive care unit (ICU), it can be a life-changing event for the partner. There is a lack of studies that focus on the partners' experiences of the time after intensive care. Aims and objectives: The aim of this study was to explore the experiences of partners of intensive care survivors and their need for support after intens

The use of mannitol in cardiopulmonary bypass prime solution-Prospective randomized double-blind clinical trial

BACKGROUND: The optimal prime solution for the cardiopulmonary bypass (CPB) circuit in adult cardiac surgery has not yet been defined. Mannitol is widely used in the priming solution for CPB despite the fact that there is no clear consensus on the role of mannitol in cardiac surgery. The aim of this study was to investigate the effect of mannitol in the CPB prime solution. METHODS: This prospectiv

CDK2 kinase activity is a regulator of male germ cell fate

The ability of men to remain fertile throughout their lives depends upon establishment of a spermatogonial stem cell (SSC) pool from gonocyte progenitors, and thereafter balancing SSC renewal vs terminal differentiation. Here, we report that precise regulation of the cell cycle is crucial for this balance. Whereas cyclin-dependent kinase 2 (Cdk2) is unnecessary for mouse viability or gametogenesis

An immunocytochemical study of the development of the olfactory system in the three-spined stickleback (Gasterosteus aculeatus L., Teleostei)

Antisera against a variety of substances have been found to produce an identical immunoreaction in the developing olfactory system of a teleost, the three-spined stickleback (Gasterosteus aculeatus). The label is localized in the olfactory placode, the olfactory nerve and those parts of the secondary olfactory tracts which constitute the dorsal descending fascicles and the ventral descending fiber