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Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. A

Platelets express Toll-like receptor 4 (TLR4), and this has been shown to be responsible for the thrombocytopenia induced by lipopolysaccharide (LPS) administration in vivo. We studied the role of LPS in mediating platelet phagocytosis by THP-1 cells in vitro by flow cytometry. Opsonization of platelets with an IgG monoclonal (W6/32) antibody or with IgG autoantibody-positive sera from patients wi

Although the communication aspects of sport and football organizations are receiving in-creased scholarly attention, research from the perspective of fans of such organizations has mostly been neglected. This study problematizes the gap that exists be-tween the current social media communication of football organizations, that tend to be guided by commercial interests, and the expectation of fans

Under 2021 frågade Historiska museet sina besökare: Vad samlar du på? Och kan du tänka dig att visa upp din samling? Vi fick svar – många svar. Här är några av dessa. Uranglas. Muminsaker. Bilmodeller. Seriealbum, plektrum, parfymer. Glasögon, böcker. Mangagrejer, gamingfigurer, pokémonprylar och flaskor med Ramune-läsk eller energidrycken Monster. Brädspel. Guld- och platinaskivor. Eller varför i

https://www.historiskamuseet.lu.se/privata-samlare - 2026-05-01

Background: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The firs

Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M protein. Here, we engineer the IgG2-4 subclasses of Ab25. Despite having reduced binding, the IgG3 version promotes stronger phagocytosis of bacteria. Using atomic

Anhedoni, minskad motivation att uppleva lust, är associerad med förändringar i belöningssystemet. Belägen i ventrala striatum utgör den bilaterala nucleus accumbens (NAcc) den centrala noden i detta nätverk, där dopamin agerar som huvudsaklig excitatorisk neurotransmitter. Studier med funktionell magnetresonanstomografi (fMRI) har visat att aktiviteten i ventrala striatum minskar under belöningsbAnhedonia, reduced motivation to experience pleasure, is associated with alterations in the circuitry of the reward system. Located in the ventral striatum, the bilateral nucleus accumbens (NAcc) is the central hub of this network where dopamine acts as the main excitatory neurotransmitter. Studies using functional magnetic resonance imaging (fMRI) found that activity in the ventral striatum is de

https://www.keg.lu.se/en/sites/keg.lu.se.en/files/utvc11_ht_2016_schedule_20150610_1.pdf - 2026-05-03

The immune processes associated with atherogenesis have received considerable attention during recent years. IgG FcRs (FcgammaR) are involved in activating the immune system and in maintaining peripheral tolerance. However, the role of the inhibitory IgG receptor FcgammaRIIB in atherosclerosis has not been defined. Bone marrow cells from FcgammaRIIB-deficient mice and C57BL/6 control mice were tra

Previous research suggests that children develop an increasing concern with fairness over the course of development. Research with adults suggests that the concern with fairness has at least two distinct components: a desire to be fair but also a desire to signal to others that they are fair. We explore whether children’s developing concern with behaving fairly towards others may in part reflect a

https://www.ses.lu.se/utbildning/studieinformation/kursplaner-litteraturlistor-och-utbildningsplaner/kursplaner-litteraturlistor-kandidatprogrammet-service-management/kursplaner-litteraturlistor-service-management-9 - 2026-05-01

2024 VT_LP2 FMSN55 CEQ Course evaluation ver 9.0 (2021-01-23) LTH Course evaluation report - CEQ, FMSN55 Basic facts Course name Statistical Modelling of Extreme Values Course code FMSN55 ECTS credits 7.5 hp Year 202324 Study period the course was finishedVT_LP2 Programme all Registrated students 68 Number answers and response rate 13 / 19 % Number answers from males 7 Number answers from females

https://www.maths.lu.se/fileadmin/maths/utbildning_education/Kursutv_VT24/FMSN55_2024_VT_LP2_arbetsrapport_en.pdf - 2026-05-02

Barbaricum 070302 Den andliga makten Entré Reception The Spiritual Beliefs Vapenoffer War Sacrifies Soldaten The Soldier Den Världsliga makten The Worldly Dominion Eldstaden The Fireplace Uppåkratemplet The Uppåkra Temple Bägaren och skålen The Beaker and the Bowl Guldgubbarna The Gold-Figure Foils Den nakna gudinnan The Naked Goddess Porten The Gate Information Information Keramiken The Ceramics

https://www.historiskamuseet.lu.se/sites/historiskamuseet.lu.se/files/2023-09/Barbaricumboken%20pdf%202007.pdf - 2026-05-03

Microsoft Word - GEOL01Installation av EndNote-2.docx Installation av EndNote För att ladda ner EndNote, gå till Studentportalen (via Lunds universitets hemsida, välj Student, sedan Studentportalen, eller http://www.student.lu.se/uPortal/render.userLayoutRootNode.uP) Logga in med ditt Stil-id. Välj Mina tjänster, sedan Hämta programvaror. Gör du detta när du befinner dig utanför Lunds universitets

https://www.geologi.lu.se/sites/geologi.lu.se/files/170321geol01-installation_av_endnote.pdf - 2026-05-03