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Introduction: Despite the publication of clinical practice guidelines, the quality of the care process as experienced by patients with osteoarthritis (OA) appears suboptimal. Hence, this study investigates how patients with OA experience their disease and care process, highlighting potential elements that can enhance or spoil it, to optimise their quality of care. Methods: A qualitative study base
The Arctic is exposed to even faster temperature changes than most other areas on Earth. Constantly increasing temperature will lead to thawing permafrost and changes in the methane (CH4) emissions from wetlands. One of the places exposed to those changes is the Abisko-Stordalen Mire in northern Sweden, where climate and vegetation studies have been conducted since the 1970s. In our study, we anal
PD-L1 expression assessed by immunohistochemical staining is used for the selection of immunotherapy in non-small cell lung cancer (NSCLC). Appropriate validation of PD-L1 expression in cytology specimens is important as cytology is often the only diagnostic material in NSCLC. In a previous study comprising two different cohorts of paired biopsies and cytological specimens, we found a fairly good
This is a critical edition of the correspondence between Queen Victoria of Sweden (1862-1930) and the Bishop and High Preacher to the Court, Gottfrid Billing (1841-1925), together with a commentary situating this surprisingly straightforward correspondence in its political and theological context. Since the queen lived both in the public and the private sphere, she had a ‘mixed’ relation to her sp
The Swedish Antarctic Research Expedition named “SWEDARP” was performed during October 1988 through April 1989. The aim of our project was to study the radioactivity in air and water from Gothenburg to the Antarctic. Between Gothenburg and the Equator, the average activity concentration of 7Be in air was 4.3 ± 0.7 mBq/m3. The activity concentration of 7Be in the South Atlantic down to Antarctica v
Abstract in UndeterminedTranslational stem cell research raises many interesting ethical questions, which have, to a greater or lesser degree, been debated at an international as well as at an interdisciplinary level. Nevertheless, there is still no international consensus regarding how a number of ethical questions related to this research should be answered. Many of these ethical questions creat
Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atheros
Köp av sexuell tjänst har i Sverige varit förbjudet sedan 1999. Införandet av förbudet var en del i arbetet mot mäns våld mot kvinnor. Lagen har därefter genomgått en rad ändringar, senast en straffskärpning 2022. I december 2022 publicerade Norges regering en offentlig utredning där ett förslag på avkriminalisering av sexköp presenterades. I Norge inspirerades man 2009 av den svenska modellen ochThe crime of purchase of sexual services has been criminalized in Sweden since 1999. The introduction of the ban was part of the work against men's violence against women. The law has subsequently undergone a series of changes, most recently a toughening of the penalty in August 2022. In December 2022, the Norwegian government published a public inquiry in which a proposal for the decriminaliz
The number of supply chain disruptions has increased over the last couple of years. The Covid-19 Pandemic, blockage of the Suez Canal and Russian invasion of Ukraine are some well-known examples of disruptions. Academia seems to have noticed the increasing disruptions and has explored proactive Supply Chain Risk Management (SCRM) as an approach to address this. Consulting firms also suggest compan
Abstract Background This study defines enterprise mobility as “The set of technology, applications, processes and policies that support the possibility to perform business activities anywhere at any time”. Enterprise Mobility is one of the main trends in the enterprise ICT environment and a leading vendor describes it as we are entering a new wave of Enterprise Computing called consumer-driven Mob
Sweden has set a climate goal that emissions generated by businesses within Sweden by 2045 should be at least 85% lower than emissions in 1990. In 2017, the construction and real estate sector accounted for 19 % of Sweden's total greenhouse gas emissions. A large part of a building's climate impact occurs during the product phase. The foundation is part of a building’s design which signifi
This paper explores an innovation case within a “smart” Swedish mid-sized city that works extensively with digitalization.Over a long period in time, city populations and city tourism have increased, while more urgentchallenges connected to sustainability have emerged along with health-related problems. In parallel the already established and ongoing digitalization of society was fortified in the
Northern forest ecosystems make up an important part of the global carbon cycle. Hence, monitoring local-scale gross primary production (GPP) of northern forest is essential for understanding climatic change impacts on terrestrial carbon sequestration and for assessing and planning management practices. Here we evaluate and compare four methods for estimating GPP using Sentinel-2 data in order to
BACKGROUND: Breast cancer, which is the most prevalent form of cancer among women globally, encompasses various subtypes that demand distinct treatment approaches. The tumor microenvironment and immune response are of crucial significance in the development and progression of breast cancer. Nevertheless, there has been scant evidence concerning the genes within breast cancer - specific immune cell
Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be
Popular Abstract in Swedish För att vi ska kunna lösa globala problem som miljöförstöring och fattigdom är det många som menar att den privata sektorn måste involveras på ett aktivt sätt. I den här avhandlingen, som består av en introduktion och fem vetenskapliga artiklar som tidigare publicerats i internationella tidskrifter, studeras ett exempel på hur privata aktörer faktiskt redan involverats It is commonly argued that the private sector needs to become actively involved for society to stand a chance of solving the most pressing global problems. This thesis, consisting of five articles previously published in refereed journals and an introductory essay, studies one case of private actor participation in global environmental governance: the Kyoto Protocol’s Clean Development Mechanism (
TAR DNA-binding protein 43 (TDP-43) pathology is linked to the neurodegenerative disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington disease (HD). Dysregulation of metabolism and emotion is shared across these disorders and may be caused by hypothalamic pathology. Inclusions with TDP-43 are present in the hypothalamus in clinical ALS, as well as selective lo
Objective Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are globally prevalent chronic diseases that affect millions of individuals in ageing populations. Hip and knee replacements are well established and effective treatments in patients suffering from end-stage OA. Understanding how T2DM influences the outcomes of these surgeries is important for optimising patient care and improving s
Introduction: The transition from pediatric to adult healthcare represents a crucial period for adolescents and youth living with HIV. When this healthcare transition is not properly managed, it can result in negative outcomes such as loss to follow-up (LTFU), increased morbidity, and mortality. Therefore, it is essential to estimate the incidence rate and identify predictors of loss to follow-up
Psoriasis is a chronic immune-mediated disease driven by genetic susceptibility and environmental factors, including microbial exposure. While HLA-C-linked variants represent the strongest genetic risk factors, their relationship with the cutaneous microbiome remains incompletely understood. This study aimed to investigate host-microbiome interactions in psoriasis through integrative multi-omics a
