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Purpose The aim of this study was to evaluate the long-term effect of 2 years of adjuvant tamoxifen compared with no systemic treatment (control) in premenopausal patients with breast cancer over different time periods through long-term (> 25 years) follow-up. Patients and Methods Premenopausal patients with primary breast cancer (N = 564) were randomly assigned to 2 years of tamoxifen (n = 276) o

Purpose The AGO-OVAR 2.29/ENGOT-ov14/PENELOPE prospectively randomized phase III trial evaluated the addition of pertuzumab to chemotherapy in patients with platinum-resistant ovarian carcinoma with low tumor human epidermal growth factor receptor 3 (HER3)mRNA expression. We report the results of the primary efficacy analysis. Patients and Methods Eligible patients had ovarian carcinoma that progr

Purpose: Tasquinimod, a novel oral therapy targeting the tumor microenvironment, significantly improved progression-free survival (PFS) in a randomized, placebo-controlled phase II trial in men with metastatic castration-resistant prostate cancer (mCRPC). This phase III study was conducted to confirm the phase II results and to detect an overall survival (OS) benefit. Patients and Methods: Men wit

Purpose: The aim of this study was to assess the performance-based visual ability among independently living elderly subjects and to investigate whether there was any association between visual ability and falls. Subjects and methods: A total of 298 randomly selected subjects aged 70-85 years were invited for an examination including monocular and binocular visual acuity (VA), contrast sensitivity

Background: TCF7L2 is a central transcription factor in the canonical wingless-type MMTV integration site (WNT) signaling pathway, and genetic variants in TCF7L2 have been found to interact with dietary fiber intake on type 2 diabetes risk. Here, we investigate whether other type 2 diabetes genes could be involved in the WNT signaling pathway and whether variants in such genes might interact with

Elevated manganese (Mn) in drinking water has been reported worldwide. While, naturally occurring Mn in groundwater is generally the major source, anthropogenic contamination by Mn-containing fungicides such as mancozeb may also occur. The main objective of this study was to examine factors associated with Mn and ethylenethiourea (ETU), a degradation product of mancozeb, in drinking water samples

BACKGROUND: Children are being infected by HIV/AIDS mainly through mother-to-child transmission. In Ethiopia currently more than 135,000 children are living with HIV/AIDS. The aim of this study was to describe the pattern of ARV uptake after birth, co-trimoxazole prophylaxis and follow up compliance, and to examine which factors are associated with the intervention outcome.METHODS: A retrospective

BACKGROUND: Transforming growth factor-β1 (TGF-β1) is a potent regulator of cell growth and differentiation. TGF-β1 has been shown to be a key player in tissue remodeling processes in a number of disease states by inducing expression of extracellular matrix proteins. In this study a quantitative proteomic analysis was undertaken to investigate if TGF-β1 contributes to tissue remodeling by mediatin

Till följd av att barnkonventionen tillträdde som svensk lag har domstolen en skyldighet att utöver rättegångsbalkens bestämmelser tillämpa barnkonventionens bestämmelser vid mål som rör barn. Vid inkorporeringen av konventionen uttryckte flera remissinstanser kritik mot att förarbetena till lagen inte gav något underlag för tolkning av de enskilda artiklarna samt att lösningar på eventuella normkAs a consequence of the incorporation of the Convention on the Rights of the Child (UNCRC) into Swedish law, courts are obliged to apply the UNCRC in provision to the Swedish Code of Judicial Procedure when children are parties or otherwise involved. Several referral bodies expressed criticism that the Swedish government in their preparatory work provided no guidance on how the individual articles

Sociologisk forskning beskriver samtiden som ett senmodernt samhällstillstånd, som kännetecknas av snabb förändring, individualisering, globalisering och osäkerhet inför framtiden. Ett av rättens syften är att påverka människors beteenden, vilket kanske tydligast manifesteras genom straffrätten. Detta examensarbete undersöker hur straffrättens mål att påverka normer och styra beteenden tar form i Sociological research describes contemporary society as a condition of late modernity, characterized by rapid change, individualisation, globalisation, and uncertainty about the future. One of the purposes of law is to influence human behaviour, insofar as this is possible. A function that is perhaps most evidently manifested through criminal law. This thesis examines how criminal law’s aim to sha

Samhället idag kännetecknas av digital interaktion, där både privata såväl som yrkesmässiga kontakter sker via olika tekniska plattformar. Människor skrol-lar, kommunicerar och tar till sig information via mobiltelefoner eller datorer vilket har blivit det normala sättet att interagera i vardagen. Allt fler rättsområ-den har tagit digitaliseringen i beaktning, men det finns fortfarande rättsområ-dSociety today is characterized by digital interaction, with both private and pro-fessional contacts taking place through various technological platforms. Peo-ple browse, communicate and absorb information via mobile phones or com-puters, which has become the normal way of interacting in everyday life. More and more areas of law have taken digitalization into account, but there are still areas of l

Photoredox catalysis with 1st row transition metals is an expanding, but challenging field of research. Using iron complexes as useful catalysts is especially difficult due to low exited state lifetimes and the need for suitable redox-potentials of the involved ground and excited states. The use of strongly σ-donating NHC-ligands led to exited state lifetimes in the pico- and nanosecond region, wh

PCDD/Fs and dl-PCBs, or more commonly referred to as dioxin and dioxin like substances are compounds present in our surrounding environment. As some congeners of these have been shown to be toxic, they are regulated under the Stockholm Convention. As dioxins are persistent in biota and have lipophilic properties they are seen accumulating in lipid rich fish in the Baltic, one of the affected speci

This thesis examines the effect of cognates on codeswitching in planned speech production in trilinguals, which has previously been unexplored. Previous studies on cognates and codeswitching have primarily focused on cognate facilitation effects in spontaneous speech in bilinguals. While experimental studies have gradually acknowledged the importance of investigating codeswitching in a sentence co

OBJECTIVE-FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO) influences BMI across adult life span. RESEARCH DESIGN AND METHODS-Through regression models, we assessed the relationship between the FTO single nucleotide polymorphisms rs9939609, type 2 diabetes, and BM

Background: Three-dimensional echocardiography (3DE) and semi-automatic right ventricular delineation has been proposed as an appropriate method for right ventricle (RV) evaluation. We aimed to examine how manual correction of semi-automatic delineation influences the accuracy of 3DE for RV volumes and function in a clinical adult setting using cardiac magnetic resonance (CMR) as the reference met

Background: A varying response to cholinesterase inhibitor (ChEI) treatment has been reported among patients with Alzheimer's disease (AD). Whether the individual-specific response, specific ChEI agent or dose affects mortality is unclear. We aimed to examine the relationship between the 6-month response to ChEI and lifespan. Methods: Six hundred and eighty-one deceased patients with a clinical AD