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INTRODUCTION: Despite favourable results from structured face-to-face treatment of osteoarthritis (OA) in Sweden through the Better management of patients with OsteoArthritis (BOA) initiative, only around 20% of people with knee or hip OA receive the primary treatment recommended by international guidelines (ie, information, exercise, weight management). In 2014, a digital treatment programme name
Introduction: Traditional validation of umbilical cord blood samples with positive veno-arterial ΔpH and arterio-venous ΔpCO2 values confirms the source of samples, whereas negative Δvalues represent mix-up of samples. To investigate whether this is true, the distributions of V-A ΔpO2 and A-V Δlactate were also explored and related to clinical characteristics. In addition, different cord blood sam
Essentially all academic research of today relies on analysis of data from a wide range of sources. Several underpinning, and rapidly developing, technologies are supporting the analysis of this data. Visualization serves as an interface to this ecosystem of tools and methods and integrates them into environments supporting scientific workflows, effectively sharing cognitive load between computers
Advances in biomarker technology, digital cognitive assessments, and amyloid-targeting therapies have redefined the opportunities for accurate and early diagnosis and care of Alzheimer's disease (AD). These advances also create new possibilities for intervention before the onset of cognitive impairment. This paradigm shift has increased the focus on Stages 1 and 2 of AD, in which individuals are c
Landslide susceptibility mapping is among the first works for disaster management and land use planning activities in a mountain area like Ganzhou City. The aims of the current study are to assess GIS-based landslide spatial modeling using four models, namely data-driven evidential belief function (EBF), frequency ratio (FR), maximum entropy (Maxent), and logistic regression (LR), and to compare t
In recent years, application of ensemble models has been increased tremendously in various types of natural hazard assessment such as landslides and floods. However, application of this kind of robust models in groundwater potential mapping is relatively new. This study applied four data mining algorithms including AdaBoost, Bagging, generalized additive model (GAM), and Naive Bayes (NB) models to
Reducing the risk exposure in investment portfolios is a constant topic in financial literature. This thesis aims to discuss and compare the risk level in portfolios of only Eastern or only Western European market indices by studying the correlation within each one of the portfolios. The correlation is estimated with two different methods: the traditional time-series and Solnik and Roulet’s (2000)
The most famous theory of family economics is probably Gary Becker’s Quantity-Quality model. Assuming scarce parental resources, it predicts a negative relationship between family size and adult success. The model assumes that parents have common preferences and that income pooling takes place. However, modern theories of household allocation have shown that the assumption of common preferences is
Objective: Using Swedish nationwide registry data, the authors investigated genetic and environmental risk factors in the etiology of drug abuse by twin sibling modeling. The authors followed up with epidemiological analyses to identify shared environmental influences on drug abuse. Method: Drug abuse was defined using public medical, legal, or pharmacy records. Twin and sibling pairs were obtaine
1. Ecological stoichiometry predicts important control of the relative abundance of the key elements carbon (C), nitrogen (N) and phosphorus (P) on trophic interactions. In a nutrient-poor Amazonian lowland rain forest of French Guiana, we tested the hypothesis that decomposers exploit stoichiometrically diverse plant litter more efficiently, resulting in faster litter decomposition compared to li
Genome-wide association studies of breast cancer have identified multiple single nucleotide polymorphisms (SNPs) that are associated with increased breast cancer risks in the general population. In a previous study, we demonstrated that the minor alleles at three of these SNPs, in FGFR2, TNRC9 and MAP3K1, also confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers. Three addi
Popular Abstract in Swedish Proteiner är nödvändiga beståndsdelar i en levande cell. Dels bygger de upp viktiga strukturer och dels katalyserar de kemiska reaktioner. Proteiner kodas av gener. Varje protein motsvaras av en gen. Vägen från gen till protein är densamma i alla organismer på jorden. Först transkriberas en gen till en molekyl kallad mRNA (budbärar-RNA, eng. messenger RNA). Detta mRNA aDegradation of mRNA is a controlled process which is as important for gene regulation as the synthesis of mRNA. This thesis focuses on mechanisms of mRNA stability and degradation in Bacillus subtilis, the model of Gram-positive bacteria. The aprE mRNA, encoding an exported protease named subtilisin, is extremely stable with a half-life of more than 25 minutes. Average mRNA half-lives in B. subtil
Popular Abstract in Swedish Hydrosilyleringsreaktionen är formellt en addition av en hydrosilan till ett omättat system. Reaktionen är oftast katalyserad av en övergångsmetall, och i denna process är det möjligt att påverka på vilket sätt additionen sker. Denna avhandling är en sammanfattning av fyra artiklar som behandlar regio-, stereo- och kemoselektivitet vid addition av hydrosilaner till konjThis thesis is a summary of four papers concerning various aspects on the transition metal catalysed hydrosilylation of 1,3-dienes. The hydrosilylation reaction is formally an addition of a hydrosilane to an unsaturated system and depending on the reaction conditions, control of stereo-, regio-, and chemo-selectivity can be achieved. Optically active heterobidentate P,N ligands were synthesised f
This thesis is a summary of six papers which concern synthesis of optically active bicyclo[2.2.2]octane derivatives. The derivatives prepared are important building blocks in a study towards a possible replacement of the diterpenoidic part of taxol, (baccatin III), so as to construct a taxol mimic. Some of the derivatives have also been developed into new bidentate ligands. TitaniumIV complexes of
Popular Abstract in Swedish Modellering och krav för automation av gradningsprocessAn increasing number of robots have been used for the finishing of castings during recent years. This is mainly due to developments to overcome problems that restricted their use during the past decade. The major difficulties have been the need to control reaction forces during metal removing by grinding operations and the lack of tools designed specially for robots. The elimination of these two p
Presented to 42 schizophrenic patients and 19 normals, by means of a percept-genetic technique, two motifs of mother and infant in close interaction (feeding and nursing) . The motifs were tagged, by subliminal presentation, with aggressive resp. "healing" sentences, in a balanced design. No effects of this tagging were discernible. A cluster-analysis (Ward s method) of the material yielded 4 fair
This thesis concerns the numerical simulations and modelling of the flow structure and scalar transport in stirred reactors. For this Large Eddy Simulations (LES) have been used. The flow situation in a stirred reactor includes several flow phenomena that are not well predicted by "standard" two-equation models, e.g. swirl, stagnation points and anisotropic turbulence. Also, using LES one can obta
Popular Abstract in Swedish Bildundervisningen i grundskolans tidigare år uppfyller inte de i Sverige uppsatta målen. De nationella utvärderingarna (NU 89) och (NU92) bekräftar detta. Lärarna säger att de saknar ämneskunskaper och utvärderingarna visar att inslag från äldre läroplaner präglar undervisningen. För att ge en bild av hur nuvarande problem kan ha uppstått presenteras i studien en histoThe art education in Swedish primary and secondary schools is far from perfect and as a result pupils seldom reach the desired standard. National evaluations in 1989 and 1992 confirm this. Teachers admit that they lack specific subject knowledge and evaluation reveals that many aspects of older curricula still prevail. The way in which the present problems may have arisen is described through the
Atrial fibrillation is the most common cardiac arrhythmia that demands medical attention. Computer-based detailed analysis of cardiac electrical signals from healthy subjects and patients with a history of atrial fibrillation has become an important tool in the further clarification of this disease. The aim of this study was to explore supraventricular conduction using the following selected techn
Wireless communication systems are by nature and by regulations limited in bandwidth and are therefore limited in capacity. Services with Quality of Service (QoS) requirements will enforce a more efficient utilisation of the available capacity. This observation motivates the development of schedulers that can deliver the required QoS as well as being resource efficient. In this thesis, we study r
